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Protein Ontology report - thrombospondin-1 isoform 1
PR:000000376 -
http://purl.obolibrary.org/obo/PR_000000376
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000376
PRO name
thrombospondin-1 isoform 1
Synonyms
PRO-Short-label
:
EXACT:
THBS1/iso:1
Definition
"A thrombospondin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by
UniProtKB:P07996-1
or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
PRO Category
sequence
Parent
PR:000000129
thrombospondin-1
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
1
Organism-Sequence
2
Modification
5
Organism-Modification
8
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
sequence
PR:000000376
thrombospondin-1 isoform 1, THBS1/iso:1
organism-sequence
PR:P07996-1
thrombospondin-1 isoform 1 (human), hTHBS1/iso:1
organism-modification
PR:000026338
thrombospondin-1 isoform 1, signal peptide removed form (human), hTHBS1/iso:1/SigPep-
Yes
organism-modification
PR:000036488
thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human), hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification
PR:000036489
thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human), hTHBS1/iso:1/Clv:2/Glyco:1
organism-modification
PR:000028966
thrombospondin-1 isoform 1 cleaved 2 (human), hTHBS1/iso:1/Clv:2
organism-sequence
PR:P35441-1
thrombospondin-1 isoform 1 (mouse), mTHBS1/iso:1
organism-modification
PR:000036485
thrombospondin-1 isoform 1, signal peptide removed form (mouse), mTHBS1/iso:1/SigPep-
Yes
organism-modification
PR:000036487
thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse), mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification
PR:000036490
thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse), mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
organism-modification
PR:000036486
thrombospondin-1 isoform 1 cleaved 2 (mouse), mTHBS1/iso:1/Clv:2
Yes
modification
PR:000000587
thrombospondin-1 isoform 1, signal peptide removed form, THBS1/iso:1/SigPep-
modification
PR:000000485
thrombospondin-1 isoform 1 cleaved and glycosylated form, THBS1/iso:1/ClvGlyco+
modification
PR:000000590
thrombospondin-1 isoform 1 cleaved 2 glycosylated form, THBS1/iso:1/Clv:2/GlycoRes+
organism-modification
PR:000036489
thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human), hTHBS1/iso:1/Clv:2/Glyco:1
organism-modification
PR:000036490
thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse), mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
modification
PR:000000589
thrombospondin-1 isoform 1, signal peptide removed glycosylated form, THBS1/iso:1/SigPep-/GlycoRes+
organism-modification
PR:000036487
thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse), mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification
PR:000036488
thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human), hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification
PR:000026338
thrombospondin-1 isoform 1, signal peptide removed form (human), hTHBS1/iso:1/SigPep-
Yes
organism-modification
PR:000036488
thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human), hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification
PR:000036489
thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human), hTHBS1/iso:1/Clv:2/Glyco:1
organism-modification
PR:000036485
thrombospondin-1 isoform 1, signal peptide removed form (mouse), mTHBS1/iso:1/SigPep-
Yes
organism-modification
PR:000036487
thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse), mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification
PR:000036490
thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse), mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
modification
PR:000000588
thrombospondin-1 isoform 1 cleaved 2, THBS1/iso:1/Clv:2
organism-modification
PR:000028966
thrombospondin-1 isoform 1 cleaved 2 (human), hTHBS1/iso:1/Clv:2
organism-modification
PR:000036486
thrombospondin-1 isoform 1 cleaved 2 (mouse), mTHBS1/iso:1/Clv:2
Yes
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000026338
hTHBS1/iso:1/SigPep-
UniProtKB:P07996-1, 19-1170 | PRO_0000035842
"A thrombospondin-1 isoform 1, signal peptide removed form in human. UniProtKB:P07996-1, 19-1170." [PRO:DNx, UniProtKB:P07996]
enables
GO:0004866
endopeptidase inhibitor activity
PMID:8751720
located_in
GO:0005615
extracellular space
PMID:15662972
PR:000036485
mTHBS1/iso:1/SigPep-
UniProtKB:P35441-1, 19-1170
"A thrombospondin-1 isoform 1, signal peptide removed form in mouse. UniProtKB:P35441-1, 19-1170." [PMID:12498716, PRO:CNA]
located_in
GO:0005615
extracellular space
PMID:12498716
PR:000036486
mTHBS1/iso:1/Clv:2
UniProtKB:P35441-1, 19-311
"A thrombospondin-1 isoform 1 cleaved 2 in mouse. UniProtKB:P35441-1, 19-311." [PMID:17082774, PRO:CNA]
acts_upstream_of_or_within
GO:0016525
negative regulation of angiogenesis
PMID:17082774
GO:0060055
angiogenesis involved in wound healing
PMID:17082774
enables
GO:0042802
identical protein binding
with
PR:000036486
mTHBS1/iso:1/Clv:2
PMID:17082774
PR:000036487
mTHBS1/iso:1/SigPep-/GlycoRes+
UniProtKB:P35441-1, 19-1170, MOD:00222|MOD:00812|MOD:00813 | PRO_0000035843, MOD:00222|MOD:00812|MOD:00813
"A thrombospondin-1 isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P35441-1, 19-1170, MOD:00222|MOD:00812|MOD:00813." [PMID:1459996, PMID:9657149, PRO:CNA]
enables
GO:0005515
protein binding
with
PR:000036486
mTHBS1/iso:1/Clv:2
PMID:1459996
GO:0050431
transforming growth factor beta binding
PMID:9657149
located_in
GO:0005615
extracellular space
PMID:9657149
PR:000036488
hTHBS1/iso:1/SigPep-/Glyco:1
UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813 | PRO_0000035842, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813
"A thrombospondin-1 isoform 1, signal peptide removed glycosylated form that is in human and has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PMID:12450399, PMID:15342643, PMID:3305519, PRO:CNA]
enables
GO:0005515
protein binding
with
PR:000028966
hTHBS1/iso:1/Clv:2
PMID:3305519
GO:0050431
transforming growth factor beta binding
PMID:15342643
PR:000036490
mTHBS1/iso:1/Clv:2/GlycoRes+
UniProtKB:P35441-1, 312-1170, MOD:00693
"A thrombospondin-1 isoform 1 cleaved 2 glycosylated form in mouse. UniProtKB:P35441-1, 312-1170, MOD:00693." [PMID:17082774, PRO:CNA]
acts_upstream_of_or_within
GO:0016525
negative regulation of angiogenesis
PMID:17082774
GO:0060055
angiogenesis involved in wound healing
PMID:17082774
