PRO Term |
GO Annotation |
Evidence |
PR:000000647 SMAD1/iso:1/Phos:1 BMP receptor-activated smad1 "A smad1 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PMID:9136927] |
enables | GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific |
PMID:10708949 |
PR:000026334 hSMAD1/iso:1/Phos:1 UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046 | phospho-R-smad1 (human) "A smad1 isoform 1 phosphorylated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PRO:DAN, Reactome:R-HSA-201464, Reactome:R-HSA-201483] |
acts_upstream_of_or_within | GO:0007165 signal transduction |
PMID:9759503 |
GO:0030509 BMP signaling pathway |
PMID:8653785 |
enables | GO:0046332 SMAD binding with PR:Q13485 deletion target in pancreatic carcinoma 4 (human) |
PMID:9136927 |
located_in | GO:0005634 nucleus |
PMID:11509558; PMID:9759503 |
PR:000026724 mSMAD1/iso:1/Phos:1 UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046 "A smad1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:12151307, PMID:12370310] |
acts_upstream_of_or_within | GO:0008285 negative regulation of cell population proliferation |
PMID:15899870 |
GO:0030509 BMP signaling pathway |
PMID:12370310; PMID:15198985 |
enables | GO:0005515 protein binding with PR:Q04211 BTG family member 2 (mouse) |
PMID:14633973 |
GO:0005515 protein binding with PR:Q8BGV5 mZNF8 |
PMID:14633973 |
GO:0005515 protein binding with PR:Q9QZH6 Ecsit |
PMID:14633973 |
located_in | GO:0005634 nucleus |
PMID:10504300; PMID:12151307; PMID:12370310 |
GO:0005667 transcription factor complex |
PMID:14633973 |
GO:0005769 early endosome |
PMID:17592637 |
PR:000036553 hSMAD1/iso:1/PhosUbiq:1 UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148 "A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN] |
acts_upstream_of_or_within | GO:0030514 negative regulation of BMP signaling pathway |
PMID:12857866 |
PR:P70340-1 mSMAD1/iso:1
"A smad1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA] |
acts_upstream_of_or_within | GO:0030509 BMP signaling pathway |
PMID:15198985; PMID:15331632; PMID:17356069 |
located_in | GO:0005737 cytoplasm |
PMID:10504300; PMID:17356069 |
PR:Q15797-1 hSMAD1/iso:1
"A smad1 isoform 1 that is encoded in the genome of human." [PRO:CNA] |
acts_upstream_of_or_within | GO:0007165 signal transduction |
PMID:8637600 |
GO:0030509 BMP signaling pathway |
PMID:8653785 |
enables | GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific |
PMID:10708949 |
GO:0005102 signaling receptor binding |
PMID:9136927; PMID:9748228 |
GO:0005515 protein binding |
PMID:17356069 |
located_in | GO:0005737 cytoplasm |
PMID:11509558 |