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Protein Ontology report - retinoblastoma-like protein 2 isoform 1 phosphorylated 2
PR:000000561 -
http://purl.obolibrary.org/obo/PR_000000561
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000561
PRO name
retinoblastoma-like protein 2 isoform 1 phosphorylated 2
Synonyms
PRO-Short-label
:
EXACT:
RBL2/iso:1/Phos:2
Definition
"A retinoblastoma-like protein 2 isoform 1 phosphorylated form that has Cdk-dependent G1 phosphorylation, and additionally phosphorylated on a Ser residue within the region linking the retinoblastoma-associated protein A and B domains, by cyclin Cdk4(6). This phosphorylation leads to ubiquitin-dependent proteolysis." [
PMID:12006580
,
PMID:12435635
]
PRO Category
modification
Parent
PR:000000459
retinoblastoma-like protein 2 isoform 1 phosphorylated form
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000000561
retinoblastoma-like protein 2 isoform 1 phosphorylated 2, RBL2/iso:1/Phos:2
organism-modification
PR:000036472
retinoblastoma-like protein 2 isoform 1 phosphorylated 2 (human), hRBL2/iso:1/Phos:2
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036472
hRBL2/iso:1/Phos:2
UniProtKB:Q08999-1, Ser-672, MOD:00046
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 2 in human. UniProtKB:Q08999-1, Ser-672, MOD:00046." [PMID:12006580, PRO:CNA]
acts_upstream_of_or_within
GO:0051726
regulation of cell cycle
PMID:12006580
enables
GO:0005515
protein binding
with
PR:Q13309
cyclin-A/CDK2-associated protein p45 (human)
PMID:12006580
NOT
GO:0030308
negative regulation of cell growth
PMID:12006580
