Protein Ontology

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Protein Ontology report - thrombospondin-1 isoform 1 cleaved 2

PR:000000588 - http://purl.obolibrary.org/obo/PR_000000588

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000000588

PRO name

thrombospondin-1 isoform 1 cleaved 2

Synonyms

PRO-Short-label:

EXACT:

THBS1/iso:1/Clv:2

Definition

"A thrombospondin-1 isoform 1 that has been proteolytically processed by ADAMTS1 to render an N-terminal domain product." [PMID:17082774]

PRO Category

modification

Parent

PR:000000376 thrombospondin-1 isoform 1
PR:000025437 thrombospondin-1 proteolytic cleavage product

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Modification	1	Organism-Modification	2

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?

modification

PR:000000588 thrombospondin-1 isoform 1 cleaved 2, THBS1/iso:1/Clv:2

organism-modification

PR:000028966 thrombospondin-1 isoform 1 cleaved 2 (human), hTHBS1/iso:1/Clv:2

organism-modification

PR:000036486 thrombospondin-1 isoform 1 cleaved 2 (mouse), mTHBS1/iso:1/Clv:2

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000036486 mTHBS1/iso:1/Clv:2 UniProtKB:P35441-1, 19-311 "A thrombospondin-1 isoform 1 cleaved 2 in mouse. UniProtKB:P35441-1, 19-311." [PMID:17082774, PRO:CNA]	acts_upstream_of_or_within	GO:0016525 negative regulation of angiogenesis	PMID:17082774
	acts_upstream_of_or_within	GO:0060055 angiogenesis involved in wound healing	PMID:17082774
	enables	GO:0042802 identical protein binding with PR:000036486 mTHBS1/iso:1/Clv:2	PMID:17082774