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Protein Ontology report - TGF-beta 1 isoform 1 mature form
PR:000000616 - http://purl.obolibrary.org/obo/PR_000000616
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000616   
  PRO nameTGF-beta 1 isoform 1 mature form 
  Synonyms
PRO-Short-label: EXACT:TGFB1/iso:1/mature
Other: RELATED:TGF-beta 1 active protein | TGF-beta 1 mature protein
  Definition"A TGF-beta 1 isoform 1 that has been processed by proteolytic cleavage and released from the latent complex. This form is the active mature protein. Example: UniProtKB:P01137-1, 279-390." [PMID:3162913, PRO:CNA, PRO:DAN] 
  PRO Categorymodification 
  ParentPR:000000397 TGF-beta 1 isoform 1
PR:000018292 TGF-beta 1 proteolytic cleavage product
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification1                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000000616 TGF-beta 1 isoform 1 mature form, TGFB1/iso:1/mature

Yes
organism-modification


PR:000025927 TGF-beta 1 isoform 1 mature form (human), hTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025928 TGF-beta 1 isoform 1 mature form (mouse), mTGFB1/iso:1/mature
Yes
organism-modification


PR:000025929 TGF-beta 1 isoform 1 mature form (rat), rTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025930 TGF-beta 1 isoform 1 mature form (green monkey), GrMonkey-TGFB1/iso:1/mature
Yes
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TGFB1/iso:1/mature forms found in complexes   

TGFB1/iso:1/mature Component
 Complexes
PR:000000616 TGFB1/iso:1/mature PR:000025925 dimeric TGF-beta 1
PR:000025927 hTGFB1/iso:1/mature PR:000025926 dimeric TGF-beta 1 (human)
PR:000025929 rTGFB1/iso:1/mature PR:000025931 dimeric TGF-beta 1 (rat)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025927 hTGFB1/iso:1/mature
UniProtKB:P01137-1, 279-390 | PRO_0000033763
"A TGF-beta 1 isoform 1 mature form in human. UniProtKB:P01137-1, 279-390." [PMID:3162913]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8471846
GO:0043066 negative regulation of apoptotic process PMID:9918798
enablesGO:0042803 protein homodimerization activity PMID:3162913; PMID:8471846
located_inGO:0031012 extracellular matrix PMID:8294500
PR:000025928 mTGFB1/iso:1/mature
UniProtKB:P04202-1, 279-390 | PRO_0000033767
"A TGF-beta 1 isoform 1 mature form in mouse. UniProtKB:P04202-1, 279-390." [PMID:2209468]		 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856
enablesGO:0005160 transforming growth factor beta receptor binding PMID:14764882
located_inGO:0031012 extracellular matrix PMID:9008713
PR:000025929 rTGFB1/iso:1/mature
UniProtKB:P17246-1, 279-390 | PRO_0000033771
"A TGF-beta 1 isoform 1 mature form in rat. UniProtKB:P17246-1, 279-390." [PMID:11453552]		 located_inGO:0031012 extracellular matrix PMID:11907708
PR:000025930 GrMonkey-TGFB1/iso:1/mature
UniProtKB:P09533-1, 279-390 | PRO_0000033761
"A TGF-beta 1 isoform 1 mature form in green monkey. UniProtKB:P09533-1, 279-390." [PMID:3185545]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:3185545
enablesGO:0042803 protein homodimerization activity PMID:3185545
located_inGO:0031012 extracellular matrix PMID:3185545