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Protein Ontology report - TGF-beta 1 isoform 1 inactive form
PR:000000618 -
http://purl.obolibrary.org/obo/PR_000000618
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000618
PRO name
TGF-beta 1 isoform 1 inactive form
Synonyms
PRO-Short-label
:
EXACT:
TGFB1/iso:1/inactive
Other
:
RELATED:
TGF beta latent complex | TGFb latent complex
Definition
"A TGF-beta 1 isoform 1, signal peptide removed form that has been cleaved at the dibasic cleavage site, rendering the latency associated peptide (LAP) and the mature protein non-covalently bound. This form is glycosylated mainly at either one or the two first consensus glycosylation sites within the LAP sequence. Example:
UniProtKB:P01137-1
, 30-278, 279-390, Asn-82,
MOD:00160
." [
PMID:3162913
,
PMID:3185545
, PRO:CNA, PRO:DAN]
PRO Category
modification
Parent
PR:000025454
TGF-beta 1 isoform 1, signal peptide removed form
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
3
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000000618
TGF-beta 1 isoform 1 inactive form, TGFB1/iso:1/inactive
organism-modification
PR:000026335
TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification
PR:000036527
TGF-beta 1 isoform 1 inactive form (green monkey), GrMonkey-TGFB1/iso:1/inactive
Yes
organism-modification
PR:000036529
TGF-beta 1 isoform 1 inactive form (mouse), mTGFB1/iso:1/inactive
Yes
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000026335
hTGFB1/iso:1/inactive
UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160 | PRO_0000033762, PRO_0000033763, Asn-82, MOD:00160
"A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:3162913
enables
NOT
GO:0005160
transforming growth factor beta receptor binding
PMID:2677679
;
PMID:3162913
GO:0042803
protein homodimerization activity
PMID:3162913
located_in
GO:0031012
extracellular matrix
PMID:17015622
;
PMID:8294500
GO:0032991
protein-containing complex
PMID:3162913
PR:000036527
GrMonkey-TGFB1/iso:1/inactive
UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160 | PRO_0000033760, PRO_0000033761, Asn-82, MOD:00160
"A TGF-beta 1 isoform 1 inactive form in green monkey, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1448117, PMID:2677679, PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:1448117
;
PMID:2677679
enables
NOT
GO:0005160
transforming growth factor beta receptor binding
PMID:1448117
located_in
GO:0032991
protein-containing complex
PMID:1448117
;
PMID:2677679
PR:000036529
mTGFB1/iso:1/inactive
UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160 | PRO_0000033766, PRO_0000033767, Asn-82, MOD:00160
"A TGF-beta 1 isoform 1 inactive form in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1821856, PMID:9008713, PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0030879
mammary gland development
PMID:1821856
located_in
GO:0031012
extracellular matrix
PMID:9008713
