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Protein Ontology report - TGF-beta 1 sequence variant R218C cleaved 2 (human)
PR:000000622 - http://purl.obolibrary.org/obo/PR_000000622
 
    Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:000000622   
  PRO nameTGF-beta 1 sequence variant R218C cleaved 2 (human) 
  Synonyms
PRO-Short-label: EXACT:hTGFB1/var:R218C/Clv:2
PRO-proteoform-std: EXACT:UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950
Other: EXACT:TGF-beta 1 sequence variant 3 cleaved 2 (human)
  Definition"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide (PR:000000621). UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:11278244, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN] 
  PRO Categoryorganism-modification 
  ParentPR:000018292 TGF-beta 1 proteolytic cleavage product
PR:000021904 TGF-beta 1 sequence variant R218C, signal peptide removed form (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Term Hierarchy
  Visualization
DAG: OLS:
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000622 hTGFB1/var:R218C/Clv:2
UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 cleaved 2 (human)
"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide (PR:000000621). UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:11278244, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN]		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244