Home
|
Linked Open Data
|
Browse
|
Search
|
Statistics
|
Download
RACE-PRO
PRO tracker
Community
PRO Consortium
Publications
Documentation
Protein Ontology report - smad3 isoform 1 acetylated and phosphorylated 1
PR:000000657 -
http://purl.obolibrary.org/obo/PR_000000657
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000657
PRO name
smad3 isoform 1 acetylated and phosphorylated 1
Synonyms
PRO-Short-label
:
EXACT:
SMAD3/iso:1/AcPhos:1
Definition
"A smad3 isoform 1 acetylated and phosphorylated form in which the phosphorylation occurs upon TGF-beta receptor activation and which has been further acetylated at a Lys residue within the MH1 domain by coactivators, such as CBP and EP300. Example:
UniProtKB:P84022-1
, Lys-19,
MOD:00064
|Ser-423/Ser-425,
MOD:00046
." [
PMID:17074756
]
PRO Category
modification
Parent
PR:000000577
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
Back to top
Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000000657
smad3 isoform 1 acetylated and phosphorylated 1, SMAD3/iso:1/AcPhos:1
organism-modification
PR:000036557
smad3 isoform 1 acetylated and phosphorylated 1 (human), hSMAD3/iso:1/AcPhos:1
Yes
Back to top
Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036557
hSMAD3/iso:1/AcPhos:1
UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:17074756
enables
GO:0003700
DNA-binding transcription factor activity
PMID:17074756
located_in
GO:0005634
nucleus
PMID:17074756