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RACE-PRO
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Documentation
Protein Ontology report - smad3 isoform 1 phosphorylated 1
PR:000000658 -
http://purl.obolibrary.org/obo/PR_000000658
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000658
PRO name
smad3 isoform 1 phosphorylated 1
Synonyms
PRO-Short-label
:
EXACT:
SMAD3/iso:1/Phos:1
Other
:
EXACT:
smad3 active
RELATED:
TGF-beta receptor-activated smad3
Definition
"A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the transforming growth factor beta signaling pathway. Example:
UniProtKB:P84022-1
, Ser-423/Ser-425,
MOD:00046
." [
PMID:8774881
]
PRO Category
modification
Parent
PR:000000578
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
2
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000000658
smad3 isoform 1 phosphorylated 1, SMAD3/iso:1/Phos:1
organism-modification
PR:000026333
smad3 isoform 1 phosphorylated 1 (human), hSMAD3/iso:1/Phos:1
Yes
organism-modification
PR:000036558
smad3 isoform 1 phosphorylated 1 (mouse), mSMAD3/iso:1/Phos:1
Yes
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000026333
hSMAD3/iso:1/Phos:1
UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046
acts_upstream_of_or_within
GO:0006366
transcription by RNA polymerase II
PMID:10823886
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:8774881
;
PMID:9380693
enables
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
PMID:10823886
;
PMID:12943993
GO:0008134
transcription factor binding
PMID:15084259
GO:0046332
SMAD binding
PMID:15350224
;
PMID:9311995
located_in
GO:0005634
nucleus
PMID:10846168
;
PMID:15280432
GO:0005667
transcription factor complex
PMID:12374795
PR:000036558
mSMAD3/iso:1/Phos:1
UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046
enables
GO:0003690
double-stranded DNA binding
PMID:15282343
GO:0003700
DNA-binding transcription factor activity
PMID:10823886
;
PMID:12943993
GO:0008134
transcription factor binding
PMID:15464984
;
PMID:9702197
located_in
GO:0005634
nucleus
PMID:12943993
;
PMID:15282343
GO:0005667
transcription factor complex
PMID:9702197
