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Protein Ontology report - smad3 isoform 1 phosphorylated 2
PR:000000659 -
http://purl.obolibrary.org/obo/PR_000000659
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000659
PRO name
smad3 isoform 1 phosphorylated 2
Synonyms
PRO-Short-label
:
EXACT:
SMAD3/iso:1/Phos:2
Definition
"A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the N-terminal Px[ST]P motif and the clusters of [ST]P motifs within the MH1-MH2 domain linker region by G1 cyclin-dependent kinases (CDK4 and CDK2) leading to CDK inhibition of its transcriptional activity and antiproliferative function. Example:
UniProtKB:Q8BUN5-1
, Thr-8/Thr-179,
MOD:00047
|Ser-213,
MOD:00046
." [
PMID:15241418
, PRO:CNA, PRO:DAN]
PRO Category
modification
Parent
PR:000000578
smad3 isoform 1 phosphorylated form
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000000659
smad3 isoform 1 phosphorylated 2, SMAD3/iso:1/Phos:2
organism-modification
PR:000036560
smad3 isoform 1 phosphorylated 2 (mouse), mSMAD3/iso:1/Phos:2
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036560
mSMAD3/iso:1/Phos:2
UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046
"A smad3 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]
enables
decreased
GO:0003700
DNA-binding transcription factor activity
relative to
PR:000036558
mSMAD3/iso:1/Phos:1
PMID:15241418
