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Protein Ontology report - cation channel sperm-associated protein 2
PR:000000670 - http://purl.obolibrary.org/obo/PR_000000670
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000670   
  PRO namecation channel sperm-associated protein 2 
  Synonyms
PRO-Short-label: EXACT:CATSPER2
Other: EXACT:CatSper2
  Definition"A CatSper channel protein that is a translation product of the human CATSPER2 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper2 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000044645
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence4                                                  Organism-Sequence 5                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:389
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000670 cation channel sperm-associated protein 2, CATSPER2

organism-gene


PR:A2ARP9 cation channel sperm-associated protein 2 (mouse), mCATSPER2
Yes
organism-sequence


PR:A2ARP9-1 cation channel sperm-associated protein 2 isoform m1 (mouse), mCATSPER2/iso:m1
Yes
organism-gene


PR:Q6AXP6 cation channel sperm-associated protein 2 (rat), rCATSPER2

organism-gene


PR:Q96P56 cation channel sperm-associated protein 2 (human), hCATSPER2

organism-sequence


PR:Q96P56-1 cation channel sperm-associated protein 2 isoform 1 (human), hCATSPER2/iso:1
Yes
organism-sequence


PR:Q96P56-2 cation channel sperm-associated protein 2 isoform 2 (human), hCATSPER2/iso:2

organism-sequence


PR:Q96P56-3 cation channel sperm-associated protein 2 isoform 3 (human), hCATSPER2/iso:3

organism-sequence


PR:Q96P56-4 cation channel sperm-associated protein 2 isoform h4 (human), hCATSPER2/iso:h4

sequence


PR:000000689 cation channel sperm-associated protein 2 isoform 1, CATSPER2/iso:1

organism-sequence


PR:Q96P56-1 cation channel sperm-associated protein 2 isoform 1 (human), hCATSPER2/iso:1
Yes
sequence


PR:000000690 cation channel sperm-associated protein 2 isoform 2, CATSPER2/iso:2

organism-sequence


PR:Q96P56-2 cation channel sperm-associated protein 2 isoform 2 (human), hCATSPER2/iso:2

sequence


PR:000000691 cation channel sperm-associated protein 2 isoform 3, CATSPER2/iso:3

organism-sequence


PR:Q96P56-3 cation channel sperm-associated protein 2 isoform 3 (human), hCATSPER2/iso:3

sequence


PR:000000692 cation channel sperm-associated protein 2 isoform m1, CATSPER2/iso:m1

organism-sequence


PR:A2ARP9-1 cation channel sperm-associated protein 2 isoform m1 (mouse), mCATSPER2/iso:m1
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:A2ARP9
mCATSPER2
Catsper2 | CatSper2 (mouse)		 acts_upstream_of_or_withinGO:0001539 cilium or flagellum-dependent cell motility PMID:14657366
GO:0030317 flagellated sperm motility PMID:14657366; PMID:17174296; PMID:17227845
PR:A2ARP9-1
mCATSPER2/iso:m1
 located_inGO:0031514 motile cilium PMID:11675491; PMID:14657366
PR:Q96P56-1
hCATSPER2/iso:1
cation channel sperm-associated protein 2 isoform Variant 2 (human)		 enablesGO:0005515 protein binding with PR:Q9P0X4 Ca(v)3.3 (human) PMID:16740636