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Protein Ontology report - cyclic nucleotide-gated channel alpha subunit
PR:000000673 - http://purl.obolibrary.org/obo/PR_000000673
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000000673   
  PRO namecyclic nucleotide-gated channel alpha subunit 
  Definition"A cyclic nucleotide-regulated channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The carboxy-terminal region contains the Cyclic nucleotide-binding domain (Pfam:PF00027) (CNBD) and a region connecting the CNBD to the S6 segment (C-linker), which is important for modulation by transition metals. In addition, CNG alpha has a carboxy-terminal leucine zipper that seems to be involved in inter-subunit interaction. CNG alpha subunits combine with the beta subunits to form the cyclic nucleotide-gated ion channels, which mediate sensory transduction in photoreceptors and olfactory sensory neurons. These channels are likely composed of four subunits around a centrally located ion-permeable pore that opens in response to the direct binding of intracellular cyclic nucleotides. CNG channels are non-selective cation channels. They are not gated by membrane voltage although their structure includes the transmembrane S4 motif known to function as the membrane voltage sensor in all voltage-gated ion channels, but it has been shown to be important for proper folding and processing. Alpha and beta subunits of the CNG channel are very similar, however only alpha subunits are able to homooligomerize and form functional channels." [PMID:12432397, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000044648 cyclic nucleotide-regulated channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family0                                                  Organism-Family 0                                        
         Gene0                                                  Organism-Gene 0                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
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Related Cross References

  Db identifiers
PIRSF:PIRSF002403
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000673 cyclic nucleotide-gated channel alpha subunit, CATSPERB

gene


PR:000000686 cGMP-gated cation channel alpha-1, CNGA1

organism-gene


PR:P29973 cGMP-gated cation channel alpha-1 (human), hCNGA1

organism-sequence


PR:000000738 cGMP-gated cation channel alpha-1 sequence variant S320F (human), hCNGA1/var:S320F
Yes
organism-sequence


PR:P29973-1 cGMP-gated cation channel alpha-1 isoform 1 (human), hCNGA1/iso:1
Yes
organism-modification


PR:000078527 cGMP-gated cation channel alpha-1 deaminated 1 (human), hCNGA1/Deam:1

organism-gene


PR:P29974 cGMP-gated cation channel alpha-1 (mouse), mCNGA1
Yes
organism-sequence


PR:P29974-1 cGMP-gated cation channel alpha-1 isoform 1 (mouse), mCNGA1/iso:1

organism-gene


PR:Q00194 cGMP-gated cation channel alpha-1 (cow), cow-CNGA1

organism-sequence


PR:Q00194-1 cGMP-gated cation channel alpha-1 isoform 1 (cow), cow-CNGA1/iso:1
Yes
organism-modification


PR:000036569 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1 (cow), cow-CNGA1/iso:1/Phos:1
Yes
organism-modification


PR:000045379 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2 (cow), cow-CNGA1/iso:1/Phos:2

organism-modification


PR:000045381 cGMP-gated cation channel alpha-1 isoform 1 unphosphorylated 1 (cow), cow-CNGA1/iso:1/UnPhos:1
Yes
organism-gene


PR:Q62927 cGMP-gated cation channel alpha-1 (rat), rCNGA1

organism-gene


PR:Q90980 cyclic nucleotide-gated channel rod photoreceptor subunit alpha (chicken), chick-CNGA1

sequence


PR:000000737 cGMP-gated cation channel alpha-1 isoform 1, CNGA1/iso:1

organism-sequence


PR:P29973-1 cGMP-gated cation channel alpha-1 isoform 1 (human), hCNGA1/iso:1
Yes
organism-sequence


PR:P29974-1 cGMP-gated cation channel alpha-1 isoform 1 (mouse), mCNGA1/iso:1

organism-sequence


PR:Q00194-1 cGMP-gated cation channel alpha-1 isoform 1 (cow), cow-CNGA1/iso:1
Yes
organism-modification


PR:000036569 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1 (cow), cow-CNGA1/iso:1/Phos:1
Yes
organism-modification


PR:000045379 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2 (cow), cow-CNGA1/iso:1/Phos:2

organism-modification


PR:000045381 cGMP-gated cation channel alpha-1 isoform 1 unphosphorylated 1 (cow), cow-CNGA1/iso:1/UnPhos:1
Yes
modification


PR:000000932 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated form, CNGA1/iso:1/PhosRes+

modification


PR:000000981 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1, CNGA1/iso:1/Phos:1

organism-modification


PR:000036569 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1 (cow), cow-CNGA1/iso:1/Phos:1
Yes
modification


PR:000045378 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2, CNGA1/iso:1/Phos:2

organism-modification


PR:000045379 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2 (cow), cow-CNGA1/iso:1/Phos:2

gene


PR:000000696 cyclic nucleotide-gated cation channel alpha-3, CNGA3





PR:000000739 cyclic nucleotide-gated cation channel alpha-3 isoform 1,

organism-sequence


PR:Q16281-1 cyclic nucleotide-gated cation channel alpha-3 isoform 1 (human), hCNGA3/iso:1
Yes




PR:000000740 cyclic nucleotide-gated cation channel alpha-3 isoform m1,





PR:Q9JJZ8-1 cyclic nucleotide-gated cation channel alpha-3 isoform m1 (mouse),

organism-gene


PR:Q16281 cyclic nucleotide-gated cation channel alpha-3 (human), hCNGA3

organism-sequence


PR:000000741 cyclic nucleotide-gated cation channel alpha-3 sequence variant R283Q (human), hCNGA3/var:R283Q
Yes
organism-sequence


PR:000000742 cyclic nucleotide-gated cation channel alpha-3 sequence variant T291R (human), hCNGA3/var:T291R
Yes
organism-sequence


PR:000000743 cyclic nucleotide-gated cation channel alpha-3 sequence variant G557R (human), hCNGA3/var:G557R
Yes
organism-sequence


PR:000000744 cyclic nucleotide-gated cation channel alpha-3 sequence variant V529M (human), hCNGA3/var:V529M
Yes
organism-sequence


PR:000000745 cyclic nucleotide-gated cation channel alpha-3 sequence variant R283W (human), hCNGA3/var:R283W
Yes
organism-sequence


PR:000000746 cyclic nucleotide-gated cation channel alpha-3 sequence variant F547L (human), hCNGA3/var:F547L
Yes
organism-sequence


PR:000000747 cyclic nucleotide-gated cation channel alpha-3 sequence variant R410W (human), hCNGA3/var:R410W
Yes
organism-sequence


PR:000000748 cyclic nucleotide-gated cation channel alpha-3 sequence variant P163L (human), hCNGA3/var:P163L
Yes
organism-sequence


PR:Q16281-1 cyclic nucleotide-gated cation channel alpha-3 isoform 1 (human), hCNGA3/iso:1
Yes
organism-sequence


PR:Q16281-2 cyclic nucleotide-gated cation channel alpha-3 isoform h2 (human), hCNGA3/iso:h2

organism-sequence


PR:Q16281-3 cyclic nucleotide-gated cation channel alpha-3 isoform h3 (human), hCNGA3/iso:h3

organism-modification


PR:000081665 cyclic nucleotide-gated cation channel alpha-3 phosphorylated 1 (human), hCNGA3/Phos:1





PR:Q90805 cyclic nucleotide-gated channel cone photoreceptor subunit alpha (chicken),





PR:Q94A76 potassium channel GORK (Arabidopsis thaliana),

organism-gene


PR:Q9JJZ8 cyclic nucleotide-gated cation channel alpha-3 (mouse), mCNGA3





PR:Q9JJZ8-1 cyclic nucleotide-gated cation channel alpha-3 isoform m1 (mouse),





PR:000000698 cyclic nucleotide-gated olfactory channel,





PR:Q00195 cyclic nucleotide-gated olfactory channel (rat),





PR:Q16280 cyclic nucleotide-gated olfactory channel (human),





PR:Q62398 cyclic nucleotide-gated olfactory channel (mouse),





PR:000005631 cyclic nucleotide-gated cation channel alpha-4,





PR:000041693 cyclic nucleotide-gated cation channel alpha-4 isoform 1,





PR:Q3UW12-1 cyclic nucleotide-gated cation channel alpha-4 isoform 1 (mouse),





PR:Q64359-1 cyclic nucleotide-gated cation channel alpha-4 isoform 1 (rat),





PR:Q8IV77-1 cyclic nucleotide-gated cation channel alpha-4 isoform 1 (human),





PR:Q3UW12 cyclic nucleotide-gated cation channel alpha-4 (mouse),





PR:Q3UW12-1 cyclic nucleotide-gated cation channel alpha-4 isoform 1 (mouse),





PR:Q3UW12-2 cyclic nucleotide-gated cation channel alpha-4 isoform m2 (mouse),





PR:Q64359 cyclic nucleotide-gated cation channel alpha-4 (rat),





PR:Q64359-1 cyclic nucleotide-gated cation channel alpha-4 isoform 1 (rat),





PR:Q8IV77 cyclic nucleotide-gated cation channel alpha-4 (human),





PR:Q8IV77-1 cyclic nucleotide-gated cation channel alpha-4 isoform 1 (human),





PR:Q8IV77-2 cyclic nucleotide-gated cation channel alpha-4 isoform h2 (human),