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Protein Ontology report - potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein
PR:000000676 - http://purl.obolibrary.org/obo/PR_000000676
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000000676   
  PRO namepotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein 
  Synonyms
Other: EXACT:f-channel
RELATED:HCN
  Definition"A cyclic nucleotide-regulated channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The N terminus has a conserved domain that is also present in other voltage-gated potassium and sodium channels. The carboxyl-terminal region contains the cyclic nucleotide-binding domain (CNBD). In addition, there is a structural element called the C-linker, the region connecting the CNBD to the S6 segment, which couples conformational changes in the ligand-binding domain to channel activation. Subunits combine to form the HCN channels. In common with CNG channels, HCN are cation channels that are modulated by cyclic nucleotide binding. Unlike CNG channels, HCN channels are voltage-gated, and are weakly selective for potassium. In contrast to most other voltage-gated channels, HCN channels open upon hyperpolarization and close at positive potential. HCN channels act as a pacemaker by regulating neuronal and cardiac firing rate, but also function as a regulator of membrane resting potential and resistance." [PMID:16382102] 
  PRO Categoryfamily 
  ParentPR:000044648
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family0                                                  Organism-Family 0                                        
         Gene0                                                  Organism-Gene 0                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038514
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000676 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein, CATSPERB

gene


PR:000000705 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, HCN1

organism-gene


PR:O60741 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (human), hHCN1

organism-gene


PR:O88704 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (mouse), mHCN1

organism-sequence


PR:O88704-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 (mouse), mHCN1/iso:1
Yes
organism-modification


PR:000036573 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 (mouse), mHCN1/iso:1/NGlyco:1
Yes
organism-gene


PR:Q9JKB0 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (rat), rHCN1

sequence


PR:000000755 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1, HCN1/iso:1

organism-sequence


PR:O88704-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 (mouse), mHCN1/iso:1
Yes
organism-modification


PR:000036573 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 (mouse), mHCN1/iso:1/NGlyco:1
Yes
modification


PR:000000935 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 glycosylated form, HCN1/iso:1/GlycoRes+

modification


PR:000000984 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1, HCN1/iso:1/NGlyco:1

organism-modification


PR:000036573 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 (mouse), mHCN1/iso:1/NGlyco:1
Yes
gene


PR:000000706 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, HCN2

organism-gene


PR:O88703 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (mouse), mHCN2

organism-sequence


PR:O88703-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 (mouse), mHCN2/iso:1
Yes
organism-modification


PR:000036574 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse), mHCN2/iso:1/NGlyco:1
Yes
organism-modification


PR:000046119 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 phosphorylated 1 (mouse), mHCN2/Phos:1

organism-modification


PR:000084040 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 deaminated 1 (mouse), mHCN2/Deam:1

organism-gene


PR:Q9JKA9 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (rat), rHCN2

organism-gene


PR:Q9UL51 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (human), hHCN2
Yes
sequence


PR:000000756 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1, HCN2/iso:1

organism-sequence


PR:O88703-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 (mouse), mHCN2/iso:1
Yes
organism-modification


PR:000036574 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse), mHCN2/iso:1/NGlyco:1
Yes
modification


PR:000000936 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 glycosylated form, HCN2/iso:1/GlycoRes+

modification


PR:000000985 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1, HCN2/iso:1/NGlyco:1

organism-modification


PR:000036574 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse), mHCN2/iso:1/NGlyco:1
Yes
gene


PR:000000707 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3, HCN3

organism-gene


PR:G5EFJ9 potassium voltage-gated channel unc-103 (worm), HCN3 (worm)

organism-sequence


PR:G5EFJ9-1 potassium voltage-gated channel unc-103 isoform a (worm), HCN3/iso:a (worm)

organism-sequence


PR:G5EFJ9-10 potassium voltage-gated channel unc-103 isoform j (worm), HCN3/iso:j (worm)

organism-sequence


PR:G5EFJ9-2 potassium voltage-gated channel unc-103 isoform c (worm), HCN3/iso:c (worm)

organism-sequence


PR:G5EFJ9-3 potassium voltage-gated channel unc-103 isoform b (worm), HCN3/iso:b (worm)

organism-sequence


PR:G5EFJ9-4 potassium voltage-gated channel unc-103 isoform h (worm), HCN3/iso:h (worm)

organism-sequence


PR:G5EFJ9-5 potassium voltage-gated channel unc-103 isoform e (worm), HCN3/iso:e (worm)

organism-sequence


PR:G5EFJ9-6 potassium voltage-gated channel unc-103 isoform d (worm), HCN3/iso:d (worm)

organism-sequence


PR:G5EFJ9-7 potassium voltage-gated channel unc-103 isoform g (worm), HCN3/iso:g (worm)

organism-sequence


PR:G5EFJ9-8 potassium voltage-gated channel unc-103 isoform f (worm), HCN3/iso:f (worm)

organism-sequence


PR:G5EFJ9-9 potassium voltage-gated channel unc-103 isoform i (worm), HCN3/iso:i (worm)

organism-gene


PR:O88705 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (mouse), mHCN3

organism-sequence


PR:O88705-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1 (mouse), mHCN3/iso:1

organism-modification


PR:000029934 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1 (mouse), mHCN3/Phos:1

organism-gene


PR:Q9JKA8 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (rat), rHCN3

organism-gene


PR:Q9P1Z3 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (human), hHCN3

sequence


PR:000000757 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1, HCN3/iso:1

organism-sequence


PR:O88705-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1 (mouse), mHCN3/iso:1

modification


PR:000029933 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1, HCN3/Phos:1

organism-modification


PR:000029934 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1 (mouse), mHCN3/Phos:1

gene


PR:000000708 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, HCN4





PR:000000758 ,





PR:000002604 ,

organism-sequence


PR:Q9Y3Q4-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 (human), hHCN4/iso:1
Yes




PR:000029935 ,

organism-modification


PR:000029936 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 (mouse), mHCN4/Phos:1

organism-gene


PR:O70507 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (mouse), mHCN4

organism-modification


PR:000029936 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 (mouse), mHCN4/Phos:1





PR:Q9JKA7 ,

organism-gene


PR:Q9TV66 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (rabbit), rabbit-HCN4





PR:Q9TV66-1 ,

organism-gene


PR:Q9Y3Q4 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human), hHCN4

organism-sequence


PR:000000759 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant D553N (human), hHCN4/var:D553N
Yes
organism-sequence


PR:000000760 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant S672R (human), hHCN4/var:S672R
Yes
organism-sequence


PR:Q9Y3Q4-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 (human), hHCN4/iso:1
Yes