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Protein Ontology report - sodium leak channel NALCN
PR:000000678 - http://purl.obolibrary.org/obo/PR_000000678
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000678   
  PRO namesodium leak channel NALCN 
  Synonyms
PRO-Short-label: EXACT:NALCN
Gene-based: RELATED:VGCNL1
Other: EXACT:CanIon | sodium leak channel non-selective protein | voltage gated channel-like protein 1
  Definition"An ion channel protein that is a translation product of the human NALCN gene or a 1:1 ortholog thereof. The prototype subunit contains four copies of the six transmembrane ion transport protein domain, but the number of copies of this domain varies among splice variants. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. They are subunits of a voltage-independent, nonselective cation channel." [PMID:17448995, PRO:CNA] 
  CommentNote: NALCN operates as part of a complex with UNC80 (PR:000017098) and UNC79 (PR:000030850) that together form a fucntional channel. [PRO:DAN, PMID:21040849]. 
  PRO Categorygene 
  ParentPR:000049983
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence3                                                  Organism-Sequence 5                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038547;IUPHARobj:750
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000678 sodium leak channel NALCN, NALCN

Yes

organism-gene



PR:Q6Q760 sodium leak channel NALCN (rat), rNALCN


organism-gene



PR:Q8BXR5 sodium leak channel NALCN (mouse), mNALCN


organism-sequence



PR:Q8BXR5-1 sodium leak channel NALCN isoform 1 (mouse), mNALCN/iso:1


organism-sequence



PR:Q8BXR5-2 sodium leak channel NALCN isoform 2 (mouse), mNALCN/iso:2


organism-gene



PR:Q8IZF0 sodium leak channel NALCN (human), hNALCN


organism-sequence



PR:Q8IZF0-1 sodium leak channel NALCN isoform 1 (human), hNALCN/iso:1


organism-sequence



PR:Q8IZF0-2 sodium leak channel NALCN isoform 2 (human), hNALCN/iso:2


organism-sequence



PR:Q8IZF0-3 sodium leak channel NALCN isoform 3 (human), hNALCN/iso:3


organism-modification



PR:000066671 sodium leak channel NALCN deaminated 1 (human), hNALCN/Deam:1


organism-modification



PR:000083319 sodium leak channel NALCN phosphorylated 1 (human), hNALCN/Phos:1


sequence



PR:000000715 sodium leak channel NALCN isoform 1, NALCN/iso:1


organism-sequence



PR:Q8BXR5-1 sodium leak channel NALCN isoform 1 (mouse), mNALCN/iso:1


organism-sequence



PR:Q8IZF0-1 sodium leak channel NALCN isoform 1 (human), hNALCN/iso:1


sequence



PR:000000716 sodium leak channel NALCN isoform 2, NALCN/iso:2


organism-sequence



PR:Q8IZF0-2 sodium leak channel NALCN isoform 2 (human), hNALCN/iso:2


sequence



PR:000000717 sodium leak channel NALCN isoform 3, NALCN/iso:3


organism-sequence



PR:Q8BXR5-2 sodium leak channel NALCN isoform 2 (mouse), mNALCN/iso:2


organism-sequence



PR:Q8IZF0-3 sodium leak channel NALCN isoform 3 (human), hNALCN/iso:3


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000678
NALCN
VGCNL1 | CanIon | sodium leak channel non-selective protein | voltage gated channel-like protein 1
acts_upstream_of_or_withinGO:0006811 monoatomic ion transport PIRSF:PIRSF038547
enablescontributes_to GO:0005216 monoatomic ion channel activity PIRSF:PIRSF038547