back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - transient receptor potential cation channel TRPA
PR:000000679 - http://purl.obolibrary.org/obo/PR_000000679
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000679   
  PRO nametransient receptor potential cation channel TRPA 
  Synonyms
PRO-Short-label: EXACT:fam:TRPA
  Definition"A transient receptor potential channel protein that is a member of the subfamily A of the transient receptor potential cation channels (TRPs), with amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The amino-terminal domain contains 14-16 copies of Ankyrin repeat (Pfam:PF00023). Most TRPs are relatively non-selective. They may be modulated by voltage changes but channel gating is generally effected by other means." [PMID:16382100, PMID:16460286, PMID:17579562, PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000044657 transient receptor potential channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
PIRSF:PIRSF038535
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000679 transient receptor potential cation channel TRPA, fam:TRPA

gene


PR:000000699 transient receptor potential cation channel TRPA1, TRPA1

organism-gene


PR:O75762 transient receptor potential cation channel subfamily A member 1 (human), hTRPA1

organism-sequence


PR:O75762-1 transient receptor potential cation channel subfamily A member 1 isoform 1 (human), hTRPA1/iso:1

organism-modification


PR:000075852 transient receptor potential cation channel subfamily A member 1 deaminated 1 (human), hTRPA1/Deam:1

organism-modification


PR:000079624 transient receptor potential cation channel subfamily A member 1 methylated 1 (human), hTRPA1/Me:1

organism-gene


PR:Q6RI86 transient receptor potential cation channel subfamily A member 1 (rat), rTRPA1

organism-gene


PR:Q7Z020 transient receptor potential cation channel subfamily A member 1 (fruit fly), fly-TRPA1

organism-sequence


PR:Q7Z020-4 transient receptor potential cation channel subfamily A member 1 isoform I (fruit fly), fly-TRPA1/iso:I

organism-sequence


PR:Q7Z020-5 transient receptor potential cation channel subfamily A member 1 isoform J (fruit fly), fly-TRPA1/iso:J

organism-gene


PR:Q8BLA8 transient receptor potential cation channel subfamily A member 1 (mouse), mTRPA1
Yes
organism-sequence


PR:Q8BLA8-1 transient receptor potential cation channel subfamily A member 1 isoform 1 (mouse), mTRPA1/iso:1
Yes
sequence


PR:000001059 transient receptor potential cation channel TRPA1 isoform 1, TRPA1/iso:1

organism-sequence


PR:O75762-1 transient receptor potential cation channel subfamily A member 1 isoform 1 (human), hTRPA1/iso:1

organism-sequence


PR:Q8BLA8-1 transient receptor potential cation channel subfamily A member 1 isoform 1 (mouse), mTRPA1/iso:1
Yes
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q8BLA8 mTRPA1
Anktm1 | Trpa1 | ankyrin-like with transmembrane domains protein 1 (mouse) | wasabi receptor (mouse)
"A transient receptor potential cation channel TRPA1 that is encoded in the genome of mouse." [OMA:Q8BLA8, PRO:DNx]		 acts_upstream_of_or_withinGO:0006816 calcium ion transport PMID:18398506
GO:0009409 response to cold PMID:12654248; PMID:16630838
GO:0009410 response to xenobiotic stimulus PMID:18272293
GO:0042542 response to hydrogen peroxide PMID:18398506
GO:0048265 response to pain PMID:18297068
GO:0048265 response to pain PMID:18297068
GO:0050955 thermoception PMID:12654248
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain PMID:16630838
GO:0050968 detection of chemical stimulus involved in sensory perception of pain PMID:18398506
GO:0050968 detection of chemical stimulus involved in sensory perception of pain PMID:18398506
GO:0050968 detection of chemical stimulus involved in sensory perception of pain PMID:18398506
GO:0050968 detection of chemical stimulus involved in sensory perception of pain PMID:18398506
GO:0050968 detection of chemical stimulus involved in sensory perception of pain PMID:18398506
enablesGO:0005216 monoatomic ion channel activity PMID:15483558
PR:Q8BLA8-1 mTRPA1/iso:1

"A transient receptor potential cation channel TRPA1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]		 acts_upstream_of_or_withinGO:0006816 calcium ion transport PMID:17588549
GO:0009409 response to cold PMID:12654248
GO:0048265 response to pain PMID:18272293
GO:0050955 thermoception PMID:12654248
enablescontributes_to GO:0005262 calcium channel activity PMID:18398506
contributes_to GO:0005262 calcium channel activity PMID:18398506
contributes_to GO:0005262 calcium channel activity PMID:18398506
GO:0015267 channel activity PMID:15483558
located_inGO:0032421 stereocilium bundle PMID:15483558