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Protein Ontology report - cyclic nucleotide-gated cation channel beta-3
PR:000000697 -
http://purl.obolibrary.org/obo/PR_000000697
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000697
PRO name
cyclic nucleotide-gated cation channel beta-3
Synonyms
PRO-Short-label
:
EXACT:
CNGB3
Gene-based
:
RELATED:
Cng6
Other
:
EXACT:
CNG channel beta-3 | cone photoreceptor cGMP-gated channel subunit beta | cyclic nucleotide-gated channel beta-3 | cyclic nucleotide-gated channel subunit CNG6
Definition
"A cyclic nucleotide-gated channel beta subunit that is a translation product of the human CNGB3 gene or a 1:1 ortholog thereof. Many members of this class are subunits of the cone cyclic nucleotide-gated cation channel, which generates the light-evoked electrical responses of cone photoreceptors." [PRO:CNA]
PRO Category
gene
Parent
PR:000000674
cyclic nucleotide-gated channel beta subunit
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
2
Sequence
3
Organism-Sequence
4
Modification
0
Organism-Modification
0
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
PIRSF:PIRSF501006
;
IUPHARobj:399
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
gene
PR:000000697
cyclic nucleotide-gated cation channel beta-3, CNGB3
organism-gene
PR:Q9JJZ9
cyclic nucleotide-gated cation channel beta-3 (mouse), mCNGB3
organism-sequence
PR:Q9JJZ9-1
cyclic nucleotide-gated cation channel beta-3 isoform 1 (mouse), mCNGB3/iso:1
Yes
organism-gene
PR:Q9NQW8
cyclic nucleotide-gated cation channel beta-3 (human), hCNGB3
organism-sequence
PR:000000752
cyclic nucleotide-gated cation channel beta-3 sequence variant S435F (human), hCNGB3/var:S435F
Yes
organism-sequence
PR:Q9NQW8-1
cyclic nucleotide-gated cation channel beta-3 isoform 1 (human), hCNGB3/iso:1
organism-sequence
PR:Q9NQW8-2
cyclic nucleotide-gated cation channel beta-3 isoform 2 (human), hCNGB3/iso:2
sequence
PR:000000749
cyclic nucleotide-gated cation channel beta-3 isoform 1, CNGB3/iso:1
organism-sequence
PR:Q9JJZ9-1
cyclic nucleotide-gated cation channel beta-3 isoform 1 (mouse), mCNGB3/iso:1
Yes
sequence
PR:000000750
cyclic nucleotide-gated cation channel beta-3 isoform 2, CNGB3/iso:2
organism-sequence
PR:Q9NQW8-2
cyclic nucleotide-gated cation channel beta-3 isoform 2 (human), hCNGB3/iso:2
sequence
PR:000000751
cyclic nucleotide-gated cation channel beta-3 isoform 3, CNGB3/iso:3
organism-sequence
PR:Q9NQW8-1
cyclic nucleotide-gated cation channel beta-3 isoform 1 (human), hCNGB3/iso:1
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000752
hCNGB3/var:S435F
UniProtKB:Q9NQW8, Ser-435, CHEBI:29997 | UniProtKB:Q9NQW8-1, Ser-435, CHEBI:29997 | cyclic nucleotide-gated cation channel beta-3 sequence variant 1 (human)
"A cyclic nucleotide-gated cation channel beta-3 (human) that has a Phe residue at the position equivalent to Ser-435 of the amino acid sequence represented by UniProtKB:Q9NQW8-1. Example: UniProtKB:Q9NQW8-1, Ser-435, CHEBI:29997." [PMID:10888875, PMID:10958649, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:13911
achromatopsia
PMID:10888875
;
PMID:10958649
PR:Q9JJZ9-1
mCNGB3/iso:1
"A cyclic nucleotide-gated cation channel beta-3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
enables
GO:0005223
intracellular cGMP-activated cation channel activity
PMID:10662822
GO:0005515
protein binding
PMID:10662822
located_in
GO:0001750
photoreceptor outer segment
PMID:15634774
GO:0005886
plasma membrane
PMID:10662822
