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Protein Ontology report - shal-related voltage-gated potassium channel alpha subunit
PR:000000710 - http://purl.obolibrary.org/obo/PR_000000710
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000710   
  PRO nameshal-related voltage-gated potassium channel alpha subunit 
  Synonyms
PRO-Short-label: EXACT:fam:Kchan_shal_sub-a
Other: RELATED:A-type potassium channel | Kv4 | pore-forming Kv4 alpha subunits
  Definition"A voltage-gated potassium channel alpha subunit that is a constituent of the Kv4 channels, responsible for transient, voltage-dependent potassium currents (A currents) in the brain and heart. The unique motif KSCASE is absolutely conserved in all shal-related channel subunits. Mutations in this region drastically affect deactivation and inactivation. This motif is located in the cytoplasmic S4-S5 loop. In common with Kv2 and Kv3 channels, the tetramerization domain at the N terminus contains a zinc binding site. Kv.4 channels are modulated by Kv4 Channel Interacting Proteins (KChIPs1-4), which bind to the cytoplasmic N-terminal domain." [PMID:15555915] 
  PRO Categoryfamily 
  ParentPR:000000685 voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 8                                        
         Sequence3                                                  Organism-Sequence 12                                        
         Modification5                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500983
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000710 shal-related voltage-gated potassium channel alpha subunit, fam:Kchan_shal_sub-a

gene


PR:000000784 voltage-gated potassium channel KCND1, KCND1

organism-gene


PR:Q03719 potassium voltage-gated channel subfamily D member 1 (mouse), mKCND1

organism-gene


PR:Q9NSA2 potassium voltage-gated channel subfamily D member 1 (human), hKCND1

organism-sequence


PR:Q9NSA2-1 potassium voltage-gated channel subfamily D member 1 isoform h1 (human), hKCND1/iso:h1

organism-sequence


PR:Q9NSA2-2 potassium voltage-gated channel subfamily D member 1 isoform h2 (human), hKCND1/iso:h2

gene


PR:000000785 voltage-gated potassium channel KCND2, KCND2

organism-gene


PR:Q5VSI1 uncharacterized protein, kcnd2 translation product (zebrafish), z-KCND2

organism-gene


PR:Q9NZV8 potassium voltage-gated channel subfamily D member 2 (human), hKCND2

organism-sequence


PR:Q9NZV8-1 potassium voltage-gated channel subfamily D member 2 isoform 1 (human), hKCND2/iso:1
Yes
organism-modification


PR:000084839 potassium voltage-gated channel subfamily D member 2 deaminated 1 (human), hKCND2/Deam:1

organism-gene


PR:Q9Z0V2 potassium voltage-gated channel subfamily D member 2 (mouse), mKCND2

organism-sequence


PR:Q9Z0V2-1 potassium voltage-gated channel subfamily D member 2 isoform 1 (mouse), mKCND2/iso:1
Yes
organism-modification


PR:000036577 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 (mouse), mKCND2/iso:1/Phos:1

organism-modification


PR:000036578 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 (mouse), mKCND2/iso:1/Phos:2
Yes
organism-modification


PR:000036579 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 (mouse), mKCND2/iso:1/Phos:3
Yes
organism-modification


PR:000036580 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 (mouse), mKCND2/iso:1/Phos:4
Yes
organism-modification


PR:000045389 voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 3 (mouse), mKCND2/iso:1/UnPhos:3
Yes
organism-modification


PR:000045390 voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 4 (mouse), mKCND2/iso:1/UnPhos:4
Yes
sequence


PR:000000947 voltage-gated potassium channel KCND2 isoform 1, KCND2/iso:1

organism-sequence


PR:Q9NZV8-1 potassium voltage-gated channel subfamily D member 2 isoform 1 (human), hKCND2/iso:1
Yes
organism-sequence


PR:Q9Z0V2-1 potassium voltage-gated channel subfamily D member 2 isoform 1 (mouse), mKCND2/iso:1
Yes
organism-modification


PR:000036577 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 (mouse), mKCND2/iso:1/Phos:1

organism-modification


PR:000036578 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 (mouse), mKCND2/iso:1/Phos:2
Yes
organism-modification


PR:000036579 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 (mouse), mKCND2/iso:1/Phos:3
Yes
organism-modification


PR:000036580 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 (mouse), mKCND2/iso:1/Phos:4
Yes
organism-modification


PR:000045389 voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 3 (mouse), mKCND2/iso:1/UnPhos:3
Yes
organism-modification


PR:000045390 voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 4 (mouse), mKCND2/iso:1/UnPhos:4
Yes
modification


PR:000000988 voltage-gated potassium channel KCND2 isoform 1 phosphorylated form, KCND2/iso:1/PhosRes+

modification


PR:000000994 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1, KCND2/iso:1/Phos:1

organism-modification


PR:000036577 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 (mouse), mKCND2/iso:1/Phos:1

modification


PR:000000995 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2, KCND2/iso:1/Phos:2

organism-modification


PR:000036578 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 (mouse), mKCND2/iso:1/Phos:2
Yes
modification


PR:000000996 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3, KCND2/iso:1/Phos:3

organism-modification


PR:000036579 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 (mouse), mKCND2/iso:1/Phos:3
Yes
modification


PR:000000997 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4, KCND2/iso:1/Phos:4

organism-modification


PR:000036580 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 (mouse), mKCND2/iso:1/Phos:4
Yes
gene


PR:000000786 voltage-gated potassium channel KCND3, KCND3

organism-gene


PR:Q62897 potassium voltage-gated channel subfamily D member 3 (rat), rKCND3

organism-sequence


PR:Q62897-1 potassium voltage-gated channel subfamily D member 3 isoform r1 (rat), rKCND3/iso:r1

organism-sequence


PR:Q62897-2 potassium voltage-gated channel subfamily D member 3 isoform r2 (rat), rKCND3/iso:r2

organism-sequence


PR:Q62897-3 potassium voltage-gated channel subfamily D member 3 isoform r3 (rat), rKCND3/iso:r3

organism-gene


PR:Q9UK17 potassium voltage-gated channel subfamily D member 3 (human), hKCND3

organism-sequence


PR:Q9UK17-1 potassium voltage-gated channel subfamily D member 3 isoform 1 (human), hKCND3/iso:1
Yes
organism-sequence


PR:Q9UK17-2 potassium voltage-gated channel subfamily D member 3 isoform 2 (human), hKCND3/iso:2
Yes
organism-gene


PR:Q9Z0V1 potassium voltage-gated channel subfamily D member 3 (mouse), mKCND3

organism-sequence


PR:Q9Z0V1-1 potassium voltage-gated channel subfamily D member 3 isoform 1 (mouse), mKCND3/iso:1

organism-sequence


PR:Q9Z0V1-2 potassium voltage-gated channel subfamily D member 3 isoform 2 (mouse), mKCND3/iso:2

organism-sequence


PR:Q9Z0V1-3 potassium voltage-gated channel subfamily D member 3 isoform m3 (mouse), mKCND3/iso:m3

sequence


PR:000000948 voltage-gated potassium channel KCND3 isoform 1, KCND3/iso:1

organism-sequence


PR:Q9UK17-1 potassium voltage-gated channel subfamily D member 3 isoform 1 (human), hKCND3/iso:1
Yes
organism-sequence


PR:Q9Z0V1-1 potassium voltage-gated channel subfamily D member 3 isoform 1 (mouse), mKCND3/iso:1

sequence


PR:000000949 voltage-gated potassium channel KCND3 isoform 2, KCND3/iso:2

organism-sequence


PR:Q9UK17-2 potassium voltage-gated channel subfamily D member 3 isoform 2 (human), hKCND3/iso:2
Yes
organism-sequence


PR:Q9Z0V1-2 potassium voltage-gated channel subfamily D member 3 isoform 2 (mouse), mKCND3/iso:2

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036578 mKCND2/iso:1/Phos:2
UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047
"A voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047." [PMID:11040264, PRO:CNA]		 located_inGO:0030425 dendrite PMID:11040264
PR:000036579 mKCND2/iso:1/Phos:3
UniProtKB:Q9Z0V2-1, Ser-552, MOD:00046
"A voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q9Z0V2-1, Ser-552, MOD:00046." [PMID:11040264, PRO:CNA]		 located_inGO:0030425 dendrite PMID:11040264
PR:000036580 mKCND2/iso:1/Phos:4
UniProtKB:Q9Z0V2-1, Thr-602/Thr-607, MOD:00047|Ser-616, MOD:00046
"A voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 in mouse. UniProtKB:Q9Z0V2-1, Thr-602/Thr-607, MOD:00047|Ser-616, MOD:00046." [PMID:11040264, PMID:16251476, PRO:CNA]		 enablesdecreased|contributes_to GO:0005250 A-type (transient outward) potassium channel activity relative to PR:000002656 PMID:16251476
located_inGO:0009986 cell surface PMID:16251476
GO:0030425 dendrite PMID:11040264
PR:000045389 mKCND2/iso:1/UnPhos:3
UniProtKB:Q9Z0V2-1, Ser-552, PR:000026291
"A potassium voltage-gated channel subfamily D member 2 isoform 1 (mouse) that lacks phosphorylation on Ser-552. UniProtKB:Q9Z0V2-1, Ser-552, PR:000026291." [PMID:12829703, PRO:CNA]		 located_inGO:0009986 cell surface PMID:12829703; PMID:16251476
PR:000045390 mKCND2/iso:1/UnPhos:4
UniProtKB:Q9Z0V2-1, Thr-602/Thr-607/Ser-616, PR:000026291
"A potassium voltage-gated channel subfamily D member 2 isoform 1 (mouse) that lacks phosphorylation on Thr-602, Thr-607, and Ser-616. UniProtKB:Q9Z0V2-1, Thr-602/Thr-607/Ser-616, PR:000026291." [PMID:16251476, PRO:CNA]		 enablescontributes_to GO:0005250 A-type (transient outward) potassium channel activity PMID:16251476
PR:Q9NZV8-1 hKCND2/iso:1

"A voltage-gated potassium channel KCND2 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0001508 action potential PMID:11102480
GO:0007268 chemical synaptic transmission PMID:11102480
located_inGO:0009986 cell surface PMID:12493773
PR:Q9UK17-1 hKCND3/iso:1
potassium voltage-gated channel subfamily D member 3 isoform KCND3L (human) | potassium voltage-gated channel subfamily D member 3 isoform Long (human)
"A voltage-gated potassium channel KCND3 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UK17]		 enablescontributes_to GO:0005250 A-type (transient outward) potassium channel activity PMID:8734615; PMID:9843794
PR:Q9UK17-2 hKCND3/iso:2
potassium voltage-gated channel subfamily D member 3 isoform KCND3S (human) | potassium voltage-gated channel subfamily D member 3 isoform Short (human)
"A voltage-gated potassium channel KCND3 isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UK17]		 enablescontributes_to GO:0005250 A-type (transient outward) potassium channel activity PMID:9843794
PR:Q9Z0V2-1 mKCND2/iso:1

"A voltage-gated potassium channel KCND2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]		 located_inGO:0005783 endoplasmic reticulum PMID:12829703