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Protein Ontology report - shaw-related voltage-gated potassium channel alpha subunit
PR:000000711 - http://purl.obolibrary.org/obo/PR_000000711
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000711   
  PRO nameshaw-related voltage-gated potassium channel alpha subunit 
  Synonyms
PRO-Short-label: EXACT:fam:Kchan_shaw_sub-a
Other: RELATED:Kv3 channel
  Definition"A voltage-gated potassium channel alpha subunit that is a constituent of Kv3 channels. These proteins are characterized by the high sequence conservation in the S5 segment which seems to determine the gating properties of the Kv3 channels: rightward shifted voltage dependence and fast deactivation rates. They also contain an ATM motif at the lysine-rich C-terminal region that is unique to this group. Kv3 channels are necessary for high-frequency, repetitive firing of action potentials. High activation threshold is a hallmark of Kv3 channels. They regulate rapid spiking, transmitter release and dendritic integration of many central neurons. In common with Kv2 and Kv4 channels, the tetramerization domain at the N terminus contains a zinc-binding site." [PMID:11506885] 
  PRO Categoryfamily 
  ParentPR:000000685 voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 13                                        
         Sequence8                                                  Organism-Sequence 21                                        
         Modification5                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500973
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000711 shaw-related voltage-gated potassium channel alpha subunit, fam:Kchan_shaw_sub-a

gene


PR:000000781 voltage-gated potassium channel KCNC1, KCNC1

organism-gene


PR:P15388 potassium voltage-gated channel subfamily C member 1 (mouse), mKCNC1

organism-sequence


PR:P15388-1 potassium voltage-gated channel subfamily C member 1, isoform Short (mouse), mKCNC1/iso:Short

organism-sequence


PR:P15388-3 potassium voltage-gated channel subfamily C member 1, isoform Long (mouse), mKCNC1/iso:Long

organism-gene


PR:P25122 potassium voltage-gated channel subfamily C member 1 (rat), rKCNC1

organism-sequence


PR:P25122-1 potassium voltage-gated channel subfamily C member 1 isoform Long (rat), rKCNC1/iso:Long
Yes
organism-modification


PR:000036575 voltage-gated potassium channel KCNC1 isoform Long phosphorylated 1 (rat), rKCNC1/iso:Long/Phos:1
Yes
organism-modification


PR:000045386 voltage-gated potassium channel KCNC1 isoform Long unphosphorylated 1 (rat), rKCNC1/iso:Long/UnPhos:1
Yes
organism-sequence


PR:P25122-2 potassium voltage-gated channel subfamily C member 1 isoform Short (rat), rKCNC1/iso:Short
Yes
organism-gene


PR:P48547 potassium voltage-gated channel subfamily C member 1 (human), hKCNC1

organism-sequence


PR:P48547-1 potassium voltage-gated channel subfamily C member 1 isoform 1 (human), hKCNC1/iso:1

organism-sequence


PR:P48547-2 potassium voltage-gated channel subfamily C member 1 isoform h2 (human), hKCNC1/iso:h2

sequence


PR:000000939 voltage-gated potassium channel KCNC1 isoform Short, KCNC1/iso:Short

organism-sequence


PR:P15388-1 potassium voltage-gated channel subfamily C member 1, isoform Short (mouse), mKCNC1/iso:Short

organism-sequence


PR:P25122-2 potassium voltage-gated channel subfamily C member 1 isoform Short (rat), rKCNC1/iso:Short
Yes
organism-sequence


PR:P48547-1 potassium voltage-gated channel subfamily C member 1 isoform 1 (human), hKCNC1/iso:1

sequence


PR:000000940 voltage-gated potassium channel KCNC1 isoform Long, KCNC1/iso:Long

organism-sequence


PR:P15388-3 potassium voltage-gated channel subfamily C member 1, isoform Long (mouse), mKCNC1/iso:Long

organism-sequence


PR:P25122-1 potassium voltage-gated channel subfamily C member 1 isoform Long (rat), rKCNC1/iso:Long
Yes
organism-modification


PR:000036575 voltage-gated potassium channel KCNC1 isoform Long phosphorylated 1 (rat), rKCNC1/iso:Long/Phos:1
Yes
organism-modification


PR:000045386 voltage-gated potassium channel KCNC1 isoform Long unphosphorylated 1 (rat), rKCNC1/iso:Long/UnPhos:1
Yes
modification


PR:000000986 voltage-gated potassium channel KCNC1 isoform Long phosphorylated form, KCNC1/iso:Long/PhosRes+

modification


PR:000000992 voltage-gated potassium channel KCNC1 isoform Long phosphorylated 1, KCNC1/iso:Long/Phos:1

organism-modification


PR:000036575 voltage-gated potassium channel KCNC1 isoform Long phosphorylated 1 (rat), rKCNC1/iso:Long/Phos:1
Yes
gene


PR:000000782 voltage-gated potassium channel KCNC2, KCNC2

organism-gene


PR:P22462 potassium voltage-gated channel subfamily C member 2 (rat), rKCNC2

organism-sequence


PR:P22462-1 potassium voltage-gated channel subfamily C member 2 isoform KV3.2B (rat), rKCNC2/iso:KV3.2B
Yes
organism-sequence


PR:P22462-2 potassium voltage-gated channel subfamily C member 2 isoform r2 (rat), rKCNC2/iso:r2

organism-sequence


PR:P22462-3 potassium voltage-gated channel subfamily C member 2 isoform KSHIIIA.1 (rat), rKCNC2/iso:KSHIIIA.1
Yes
organism-sequence


PR:P22462-4 potassium voltage-gated channel subfamily C member 2 isoform r4 (rat), rKCNC2/iso:r4

organism-gene


PR:Q14B80 potassium voltage-gated channel subfamily C member 2 (mouse), mKCNC2

organism-gene


PR:Q96PR1 potassium voltage-gated channel subfamily C member 2 (human), hKCNC2

organism-sequence


PR:Q96PR1-1 potassium voltage-gated channel subfamily C member 2 isoform 1 (human), hKCNC2/iso:1

organism-sequence


PR:Q96PR1-2 potassium voltage-gated channel subfamily C member 2 isoform 2 (human), hKCNC2/iso:2

organism-sequence


PR:Q96PR1-3 potassium voltage-gated channel subfamily C member 2 isoform 3 (human), hKCNC2/iso:3

organism-sequence


PR:Q96PR1-4 potassium voltage-gated channel subfamily C member 2 isoform 4 (human), hKCNC2/iso:4

organism-sequence


PR:Q96PR1-5 potassium voltage-gated channel subfamily C member 2 isoform h5 (human), hKCNC2/iso:h5

organism-sequence


PR:Q96PR1-6 potassium voltage-gated channel subfamily C member 2 isoform h6 (human), hKCNC2/iso:h6

sequence


PR:000000941 voltage-gated potassium channel KCNC2 isoform 1, KCNC2/iso:1

organism-sequence


PR:P22462-1 potassium voltage-gated channel subfamily C member 2 isoform KV3.2B (rat), rKCNC2/iso:KV3.2B
Yes
organism-sequence


PR:Q96PR1-1 potassium voltage-gated channel subfamily C member 2 isoform 1 (human), hKCNC2/iso:1

sequence


PR:000000942 voltage-gated potassium channel KCNC2 isoform 2, KCNC2/iso:2

organism-sequence


PR:Q96PR1-2 potassium voltage-gated channel subfamily C member 2 isoform 2 (human), hKCNC2/iso:2

sequence


PR:000000943 voltage-gated potassium channel KCNC2 isoform 3, KCNC2/iso:3

organism-sequence


PR:P22462-3 potassium voltage-gated channel subfamily C member 2 isoform KSHIIIA.1 (rat), rKCNC2/iso:KSHIIIA.1
Yes
organism-sequence


PR:Q96PR1-3 potassium voltage-gated channel subfamily C member 2 isoform 3 (human), hKCNC2/iso:3

sequence


PR:000000944 voltage-gated potassium channel KCNC2 isoform 4, KCNC2/iso:4

organism-sequence


PR:Q96PR1-4 potassium voltage-gated channel subfamily C member 2 isoform 4 (human), hKCNC2/iso:4

gene


PR:000000783 voltage-gated potassium channel KCNC4, KCNC4

organism-gene


PR:E1C3U8 uncharacterized protein, KCNC4 translation product (chicken), chick-KCNC4

organism-gene


PR:Q03721 potassium voltage-gated channel subfamily C member 4 (human), hKCNC4

organism-sequence


PR:Q03721-1 potassium voltage-gated channel subfamily C member 4 isoform 1 (human), hKCNC4/iso:1

organism-sequence


PR:Q03721-2 potassium voltage-gated channel subfamily C member 4 isoform 2 (human), hKCNC4/iso:2

organism-modification


PR:000036576 voltage-gated potassium channel KCNC4 isoform 2 phosphorylated 1 (human), hKCNC4/iso:2/Phos:1
Yes
organism-modification


PR:000045387 voltage-gated potassium channel KCNC4 isoform 2 unphosphorylated 1 (human), hKCNC4/iso:2/UnPhos:1
Yes
organism-sequence


PR:Q03721-3 potassium voltage-gated channel subfamily C member 4 isoform h3 (human), hKCNC4/iso:h3

organism-gene


PR:Q63734 potassium voltage-gated channel subfamily C member 4 (rat), rKCNC4

organism-gene


PR:Q8R1C0 potassium voltage-gated channel subfamily C member 4 (mouse), mKCNC4

sequence


PR:000000945 voltage-gated potassium channel KCNC4 isoform 1, KCNC4/iso:1

organism-sequence


PR:Q03721-1 potassium voltage-gated channel subfamily C member 4 isoform 1 (human), hKCNC4/iso:1

sequence


PR:000000946 voltage-gated potassium channel KCNC4 isoform 2, KCNC4/iso:2

organism-sequence


PR:Q03721-2 potassium voltage-gated channel subfamily C member 4 isoform 2 (human), hKCNC4/iso:2

organism-modification


PR:000036576 voltage-gated potassium channel KCNC4 isoform 2 phosphorylated 1 (human), hKCNC4/iso:2/Phos:1
Yes
organism-modification


PR:000045387 voltage-gated potassium channel KCNC4 isoform 2 unphosphorylated 1 (human), hKCNC4/iso:2/UnPhos:1
Yes
modification


PR:000000987 voltage-gated potassium channel KCNC4 isoform 2 phosphorylated form, KCNC4/iso:2/PhosRes+

modification


PR:000000993 voltage-gated potassium channel KCNC4 isoform 2 phosphorylated 1, KCNC4/iso:2/Phos:1

organism-modification


PR:000036576 voltage-gated potassium channel KCNC4 isoform 2 phosphorylated 1 (human), hKCNC4/iso:2/Phos:1
Yes
modification


PR:000002655 voltage-gated potassium channel KCNC4 isoform 2 unmodified form, KCNC4/iso:2/UnMod

gene


PR:000009254 voltage-gated potassium channel KCNC3, KCNC3

organism-gene


PR:Q01956 potassium voltage-gated channel subfamily C member 3 (rat), rKCNC3

organism-sequence


PR:Q01956-1 potassium voltage-gated channel subfamily C member 3 isoform rKSHIIID.1 (rat), rKCNC3/iso:rKSHIIID.1

organism-sequence


PR:Q01956-2 potassium voltage-gated channel subfamily C member 3 isoform rKSHIIID.2 (rat), rKCNC3/iso:rKSHIIID.2

organism-gene


PR:Q14003 potassium voltage-gated channel subfamily C member 3 (human), hKCNC3

organism-gene


PR:Q63959 potassium voltage-gated channel subfamily C member 3 (mouse), mKCNC3

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036575 rKCNC1/iso:Long/Phos:1
UniProtKB:P25122-1, Ser-503, MOD:00046 | rKCNC1/iso:2/Phos:1 | voltage-gated potassium channel KCNC1 isoform 2 phosphorylated 1 (rat)
"A voltage-gated potassium channel KCNC1 isoform Long phosphorylated 1 in rat. UniProtKB:P25122-1, Ser-503, MOD:00046." [PMID:16595659, PRO:CNA]		 enablesdecreased|contributes_to GO:0005249 voltage-gated potassium channel activity relative to PR:000002649 PMID:16595659
located_inGO:0016020 membrane PMID:16595659
PR:000036576 hKCNC4/iso:2/Phos:1
UniProtKB:Q03721-2, Ser-8/Ser-9/Ser-15/Ser-21, MOD:00046
"A voltage-gated potassium channel KCNC4 isoform 2 phosphorylated 1 in human. UniProtKB:Q03721-2, Ser-8/Ser-9/Ser-15/Ser-21, MOD:00046." [PMID:7993631, PMID:9649584, PRO:CNA]		 enablesdecreased|contributes_to GO:0005250 A-type (transient outward) potassium channel activity relative to PR:000002655 KCNC4/iso:2/UnMod PMID:7993631; PMID:9649584
PR:000045386 rKCNC1/iso:Long/UnPhos:1
UniProtKB:P25122-1, Ser-503, PR:000026291 | rKCNC1/iso:2/UnPhos:1
"A potassium voltage-gated channel subfamily C member 1 isoform Long (rat) that lacks phosphorylation on Ser-503. UniProtKB:P25122-1, Ser-503, PR:000026291." [PMID:16595659, PRO:CNA]		 enablescontributes_to GO:0005249 voltage-gated potassium channel activity PMID:16595659
PR:000045387 hKCNC4/iso:2/UnPhos:1
UniProtKB:Q03721-2, Ser-8/Ser-9/Ser-15/Ser-21, PR:000026291
"A potassium voltage-gated channel subfamily C member 4 isoform 2 (human) that lacks phosphorylation on Ser-8, Ser-9, Ser-15 and Ser-21. UniProtKB:Q03721-2, Ser-8/Ser-9/Ser-15/Ser-21, PR:000026291." [PMID:7993631, PMID:9649584, PRO:CNA]		 enablescontributes_to GO:0005250 A-type (transient outward) potassium channel activity PMID:1381835; PMID:7993631; PMID:9649584
PR:P22462-1 rKCNC2/iso:KV3.2B

"A voltage-gated potassium channel KCNC2 isoform 1 that is encoded in the genome of rat." [PRO:DNx, UniProtKB:P22462]		 enablescontributes_to GO:0015271 outward rectifier potassium channel activity PMID:1879548
PR:P22462-3 rKCNC2/iso:KSHIIIA.1

"A voltage-gated potassium channel KCNC2 isoform 3 that is encoded in the genome of rat." [PRO:CNA]		 enablescontributes_to GO:0005249 voltage-gated potassium channel activity PMID:10414303; PMID:11506885
PR:P25122-1 rKCNC1/iso:Long
Kcnc1 isoform 1 (rat) | potassium voltage-gated channel subfamily C member 1 isoform 1 (rat)
"A voltage-gated potassium channel KCNC1 isoform Long that is encoded in the genome of rat." [PRO:CNA]		 enablesGO:0030506 ankyrin binding with PR:O70511 ANK-3 (rat) PMID:18094255
located_inGO:0030424 axon PMID:18094255
PR:P25122-2 rKCNC1/iso:Short
Kcnc1 isoform 2 (rat) | potassium voltage-gated channel subfamily C member 1 isoform 2 (rat)
"A voltage-gated potassium channel KCNC1 isoform Short that is encoded in the genome of rat." [PRO:CNA]		 located_inGO:0032809 neuronal cell body membrane PMID:18094255