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Protein Ontology report - voltage-gated potassium channel subunit KCNQ2
PR:000000729 - http://purl.obolibrary.org/obo/PR_000000729
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000729   
  PRO namevoltage-gated potassium channel subunit KCNQ2 
  Synonyms
PRO-Short-label: EXACT:KCNQ2
Gene-based: RELATED:Kqt2
Other: EXACT:KQT-like 2 | neuroblastoma-specific potassium channel subunit alpha KvLQT2 | potassium channel subunit alpha KvLQT2 | voltage-gated potassium channel subunit Kv7.2
  Definition"A voltage-gated potassium channel subunit KQT that is a translation product of the human KCNQ2 gene or a 1:1 ortholog thereof. Most of the isoforms are generated by splicing that is restricted to a region that encodes the intracellular C-terminal domain of the channel (exons 7-16 in rat). From these, there are two main classes, one containing exon 16 in-frame, and others with an alternative splice junction in exon 14 that results in a frameshift and early termination. In addition, exons 12 and 13 have alternative splice junctions, and exons 8,11, and 15a are subject to splicing. Many members of this class can form heteromeric channels with members of the class KCNQ3 (PR:000000730). Some forms of KCNQ2 contain two binding calmodulin binding sites and calmodulin is tethered constitutively to KCNQ channels." [PMID:11230508, PMID:12223552
  PRO Categorygene 
  ParentPR:000000684
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence16                                                  Organism-Sequence 38                                        
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500965;IUPHARobj:561
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000729 voltage-gated potassium channel subunit KCNQ2, KCNQ2


organism-gene



PR:O43526 potassium voltage-gated channel subfamily KQT member 2 (human), hKCNQ2


organism-sequence



PR:000000907 voltage-gated potassium channel subunit KCNQ2 sequence variant S247W (human), hKCNQ2/var:S247W

Yes

organism-sequence



PR:000000908 voltage-gated potassium channel subunit KCNQ2 sequence variant H228Q (human), hKCNQ2/var:H228Q

Yes

organism-sequence



PR:000000909 voltage-gated potassium channel subunit KCNQ2 sequence variant R207W (human), hKCNQ2/var:R207W

Yes

organism-sequence



PR:000000910 voltage-gated potassium channel subunit KCNQ2 sequence variant L243F (human), hKCNQ2/var:L243F

Yes

organism-sequence



PR:000000911 voltage-gated potassium channel subunit KCNQ2 sequence variant 4 (human), hKCNQ2/var:4

Yes

organism-sequence



PR:000000912 voltage-gated potassium channel subunit KCNQ2 sequence variant Y284C (human), hKCNQ2/var:Y284C

Yes

organism-sequence



PR:000000913 voltage-gated potassium channel subunit KCNQ2 sequence variant A306T (human), hKCNQ2/var:A306T

Yes

organism-sequence



PR:000000914 voltage-gated potassium channel subunit KCNQ2 sequence variant R333Q (human), hKCNQ2/var:R333Q

Yes

organism-sequence



PR:000000915 voltage-gated potassium channel subunit KCNQ2 sequence variant M208V (human), hKCNQ2/var:M208V

Yes

organism-sequence



PR:O43526-1 potassium voltage-gated channel subfamily KQT member 2 isoform 1 (human), hKCNQ2/iso:1


organism-sequence



PR:O43526-2 potassium voltage-gated channel subfamily KQT member 2 isoform 2 (human), hKCNQ2/iso:2

Yes

organism-sequence



PR:O43526-3 potassium voltage-gated channel subfamily KQT member 2 isoform 3 (human), hKCNQ2/iso:3


organism-sequence



PR:000000916 voltage-gated potassium channel subunit KCNQ2 isoform 3 sequence variant K526N (human), hKCNQ2/iso:3/var:K526N

Yes

organism-sequence



PR:O43526-4 potassium voltage-gated channel subfamily KQT member 2 isoform 4 (human), hKCNQ2/iso:4

Yes

organism-sequence



PR:O43526-5 potassium voltage-gated channel subfamily KQT member 2 isoform 5 (human), hKCNQ2/iso:5


organism-sequence



PR:O43526-6 potassium voltage-gated channel subfamily KQT member 2 isoform 6 (human), hKCNQ2/iso:6

Yes

organism-modification



PR:000076442 potassium voltage-gated channel subfamily KQT member 2 acetylated 1 (human), hKCNQ2/Ac:1


organism-modification



PR:000079703 potassium voltage-gated channel subfamily KQT member 2 phosphorylated 1 (human), hKCNQ2/Phos:1


organism-gene



PR:O88943 potassium voltage-gated channel subfamily KQT member 2 (rat), rKCNQ2


organism-sequence



PR:O88943-1 potassium voltage-gated channel subfamily KQT member 2 isoform A (rat), rKCNQ2/iso:A

Yes

organism-sequence



PR:O88943-2 potassium voltage-gated channel subfamily KQT member 2 isoform B (rat), rKCNQ2/iso:B


organism-sequence



PR:O88943-3 potassium voltage-gated channel subfamily KQT member 2 isoform C (rat), rKCNQ2/iso:C


organism-sequence



PR:O88943-4 potassium voltage-gated channel subfamily KQT member 2 isoform D (rat), rKCNQ2/iso:D


organism-sequence



PR:O88943-5 potassium voltage-gated channel subfamily KQT member 2 isoform E (rat), rKCNQ2/iso:E


organism-sequence



PR:O88943-6 potassium voltage-gated channel subfamily KQT member 2 isoform F (rat), rKCNQ2/iso:F


organism-sequence



PR:O88943-7 potassium voltage-gated channel subfamily KQT member 2 isoform G (rat), rKCNQ2/iso:G


organism-sequence



PR:O88943-8 potassium voltage-gated channel subfamily KQT member 2 isoform H (rat), rKCNQ2/iso:H


organism-sequence



PR:O88943-9 potassium voltage-gated channel subfamily KQT member 2 isoform I (rat), rKCNQ2/iso:I


organism-gene



PR:Q9Z351 potassium voltage-gated channel subfamily KQT member 2 (mouse), mKCNQ2


organism-sequence



PR:Q9Z351-1 potassium voltage-gated channel subfamily KQT member 2 isoform 1 (mouse), mKCNQ2/iso:1


organism-sequence



PR:Q9Z351-10 potassium voltage-gated channel subfamily KQT member 2 isoform 10 (mouse), mKCNQ2/iso:10

Yes

organism-sequence



PR:Q9Z351-11 potassium voltage-gated channel subfamily KQT member 2 isoform 11 (mouse), mKCNQ2/iso:11

Yes

organism-sequence



PR:Q9Z351-12 potassium voltage-gated channel subfamily KQT member 2 isoform 12 (mouse), mKCNQ2/iso:12

Yes

organism-sequence



PR:Q9Z351-13 potassium voltage-gated channel subfamily KQT member 2 isoform m13 (mouse), mKCNQ2/iso:m13


organism-sequence



PR:Q9Z351-2 potassium voltage-gated channel subfamily KQT member 2 isoform 2 (mouse), mKCNQ2/iso:2


organism-sequence



PR:Q9Z351-3 potassium voltage-gated channel subfamily KQT member 2 isoform 3 (mouse), mKCNQ2/iso:3


organism-sequence



PR:Q9Z351-4 potassium voltage-gated channel subfamily KQT member 2 isoform 4 (mouse), mKCNQ2/iso:4


organism-sequence



PR:Q9Z351-5 potassium voltage-gated channel subfamily KQT member 2 isoform 5 (mouse), mKCNQ2/iso:5


organism-sequence



PR:Q9Z351-6 potassium voltage-gated channel subfamily KQT member 2 isoform 6 (mouse), mKCNQ2/iso:6


organism-sequence



PR:Q9Z351-7 potassium voltage-gated channel subfamily KQT member 2 isoform 7 (mouse), mKCNQ2/iso:7


organism-sequence



PR:Q9Z351-8 potassium voltage-gated channel subfamily KQT member 2 isoform 8 (mouse), mKCNQ2/iso:8


organism-sequence



PR:Q9Z351-9 potassium voltage-gated channel subfamily KQT member 2 isoform 9 (mouse), mKCNQ2/iso:9

Yes

sequence



PR:000000891 voltage-gated potassium channel subunit KCNQ2 isoform 1, KCNQ2/iso:1


organism-sequence



PR:O43526-1 potassium voltage-gated channel subfamily KQT member 2 isoform 1 (human), hKCNQ2/iso:1


organism-sequence



PR:Q9Z351-12 potassium voltage-gated channel subfamily KQT member 2 isoform 12 (mouse), mKCNQ2/iso:12

Yes

sequence



PR:000000892 voltage-gated potassium channel subunit KCNQ2 isoform 10, KCNQ2/iso:10


organism-sequence



PR:Q9Z351-10 potassium voltage-gated channel subfamily KQT member 2 isoform 10 (mouse), mKCNQ2/iso:10

Yes

sequence



PR:000000893 voltage-gated potassium channel subunit KCNQ2 isoform 11, KCNQ2/iso:11


organism-sequence



PR:Q9Z351-11 potassium voltage-gated channel subfamily KQT member 2 isoform 11 (mouse), mKCNQ2/iso:11

Yes

sequence



PR:000000894 voltage-gated potassium channel subunit KCNQ2 isoform 12, KCNQ2/iso:12


organism-sequence



PR:Q9Z351-2 potassium voltage-gated channel subfamily KQT member 2 isoform 2 (mouse), mKCNQ2/iso:2


sequence



PR:000000895 voltage-gated potassium channel subunit KCNQ2 isoform 13, KCNQ2/iso:13


organism-sequence



PR:Q9Z351-3 potassium voltage-gated channel subfamily KQT member 2 isoform 3 (mouse), mKCNQ2/iso:3


sequence



PR:000000896 voltage-gated potassium channel subunit KCNQ2 isoform 14, KCNQ2/iso:14


organism-sequence



PR:Q9Z351-4 potassium voltage-gated channel subfamily KQT member 2 isoform 4 (mouse), mKCNQ2/iso:4


sequence



PR:000000897 voltage-gated potassium channel subunit KCNQ2 isoform 15, KCNQ2/iso:15


organism-sequence



PR:Q9Z351-5 potassium voltage-gated channel subfamily KQT member 2 isoform 5 (mouse), mKCNQ2/iso:5


sequence



PR:000000898 voltage-gated potassium channel subunit KCNQ2 isoform 16, KCNQ2/iso:16


organism-sequence



PR:Q9Z351-6 potassium voltage-gated channel subfamily KQT member 2 isoform 6 (mouse), mKCNQ2/iso:6


sequence



PR:000000899 voltage-gated potassium channel subunit KCNQ2 isoform 2, KCNQ2/iso:2


organism-sequence



PR:O43526-2 potassium voltage-gated channel subfamily KQT member 2 isoform 2 (human), hKCNQ2/iso:2

Yes

organism-sequence



PR:O88943-1 potassium voltage-gated channel subfamily KQT member 2 isoform A (rat), rKCNQ2/iso:A

Yes

organism-sequence



PR:Q9Z351-1 potassium voltage-gated channel subfamily KQT member 2 isoform 1 (mouse), mKCNQ2/iso:1


modification



PR:000002632 voltage-gated potassium channel subunit KCNQ2 isoform 2 unmodified form, KCNQ2/iso:2/UnMod


sequence



PR:000000900 voltage-gated potassium channel subunit KCNQ2 isoform 3, KCNQ2/iso:3


organism-sequence



PR:O43526-3 potassium voltage-gated channel subfamily KQT member 2 isoform 3 (human), hKCNQ2/iso:3


organism-sequence



PR:000000916 voltage-gated potassium channel subunit KCNQ2 isoform 3 sequence variant K526N (human), hKCNQ2/iso:3/var:K526N

Yes

organism-sequence



PR:O88943-3 potassium voltage-gated channel subfamily KQT member 2 isoform C (rat), rKCNQ2/iso:C


sequence



PR:000000901 voltage-gated potassium channel subunit KCNQ2 isoform 4, KCNQ2/iso:4


organism-sequence



PR:O43526-4 potassium voltage-gated channel subfamily KQT member 2 isoform 4 (human), hKCNQ2/iso:4

Yes

sequence



PR:000000902 voltage-gated potassium channel subunit KCNQ2 isoform 5, KCNQ2/iso:5


organism-sequence



PR:O43526-5 potassium voltage-gated channel subfamily KQT member 2 isoform 5 (human), hKCNQ2/iso:5


sequence



PR:000000903 voltage-gated potassium channel subunit KCNQ2 isoform 6, KCNQ2/iso:6


organism-sequence



PR:O43526-6 potassium voltage-gated channel subfamily KQT member 2 isoform 6 (human), hKCNQ2/iso:6

Yes

sequence



PR:000000904 voltage-gated potassium channel subunit KCNQ2 isoform 7, KCNQ2/iso:7


organism-sequence



PR:Q9Z351-7 potassium voltage-gated channel subfamily KQT member 2 isoform 7 (mouse), mKCNQ2/iso:7


sequence



PR:000000905 voltage-gated potassium channel subunit KCNQ2 isoform 8, KCNQ2/iso:8


organism-sequence



PR:Q9Z351-8 potassium voltage-gated channel subfamily KQT member 2 isoform 8 (mouse), mKCNQ2/iso:8


sequence



PR:000000906 voltage-gated potassium channel subunit KCNQ2 isoform 9, KCNQ2/iso:9


organism-sequence



PR:Q9Z351-9 potassium voltage-gated channel subfamily KQT member 2 isoform 9 (mouse), mKCNQ2/iso:9

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000907
hKCNQ2/var:S247W
UniProtKB:O43526, Ser-247, CHEBI:29954 | UniProtKB:O43526-1, Ser-247, CHEBI:29954 | voltage-gated potassium channel subunit KCNQ2 sequence variant 1 (human)
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:12742592
enablesdecreased GO:0005249 voltage-gated potassium channel activity relative to PR:000002632 KCNQ2/iso:2/UnMod PMID:12742592
PR:000000908
hKCNQ2/var:H228Q
UniProtKB:O43526, His-228, CHEBI:30011 | UniProtKB:O43526-1, His-228, CHEBI:30011 | voltage-gated potassium channel subunit KCNQ2 sequence variant 10 (human)
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:14534157
PR:000000909
hKCNQ2/var:R207W
UniProtKB:O43526, Arg-207, CHEBI:29954 | UniProtKB:O43526-1, Arg-207, CHEBI:29954 | voltage-gated potassium channel subunit KCNQ2 sequence variant 2 (human)
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:11572947
enablesdecreased GO:0005249 voltage-gated potassium channel activity relative to PR:000002632 KCNQ2/iso:2/UnMod PMID:11572947
PR:000000910
hKCNQ2/var:L243F
UniProtKB:O43526, Leu-243, CHEBI:29997 | UniProtKB:O43526-1, Leu-243, CHEBI:29997 | voltage-gated potassium channel subunit KCNQ2 sequence variant 3 (human)
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:14534157
PR:000000911
hKCNQ2/var:4
UniProtKB:O43526, Arg-214, CHEBI:29954 | UniProtKB:O43526-1, Arg-214, CHEBI:29954
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:11175290
PR:000000912
hKCNQ2/var:Y284C
UniProtKB:O43526, Tyr-284, CHEBI:29950 | UniProtKB:O43526-1, Tyr-284, CHEBI:29950 | voltage-gated potassium channel subunit KCNQ2 sequence variant 5 (human)
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:10788442
located_inGO:0009986 cell surface PMID:10788442
PR:000000913
hKCNQ2/var:A306T
UniProtKB:O43526, Ala-306, CHEBI:30013 | UniProtKB:O43526-1, Ala-306, CHEBI:30013 | voltage-gated potassium channel subunit KCNQ2 sequence variant 6 (human)
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:10788442
located_inGO:0009986 cell surface PMID:10788442
PR:000000914
hKCNQ2/var:R333Q
UniProtKB:O43526, Arg-333, CHEBI:30011 | UniProtKB:O43526-1, Arg-333, CHEBI:30011 | voltage-gated potassium channel subunit KCNQ2 sequence variant 7 (human)
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:14534157
PR:000000915
hKCNQ2/var:M208V
UniProtKB:O43526, Met-208, CHEBI:30015 | UniProtKB:O43526-1, Met-208, CHEBI:30015 | voltage-gated potassium channel subunit KCNQ2 sequence variant 8 (human)
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:14534157
PR:000000916
hKCNQ2/iso:3/var:K526N
UniProtKB:O43526-3, Lys-526, CHEBI:50347 | voltage-gated potassium channel subunit KCNQ2 sequence variant 9 (human)
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:15249611
PR:O43526-2
hKCNQ2/iso:2
enablescontributes_to GO:0005249 voltage-gated potassium channel activity PMID:11160379
PR:O43526-4
hKCNQ2/iso:4
enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9836639
PR:O43526-6
hKCNQ2/iso:6
potassium voltage-gated channel subfamily KQT member 2 isoform HNSPC (human)
enablesdecreased|contributes_to GO:0005249 voltage-gated potassium channel activity relative to PR:000002632 KCNQ2/iso:2/UnMod PMID:9039501
PR:O88943-1
rKCNQ2/iso:A
enablescontributes_to GO:0005249 voltage-gated potassium channel activity PMID:11038262
PR:Q9Z351-10
mKCNQ2/iso:10
potassium voltage-gated channel subfamily KQT member 2 isoform MKQT2.10 (mouse)
enablesNOT GO:0022832 voltage-gated channel activity PMID:9666519
PR:Q9Z351-11
mKCNQ2/iso:11
potassium voltage-gated channel subfamily KQT member 2 isoform MKQT2.11 (mouse)
enablesNOT GO:0022832 voltage-gated channel activity PMID:9666519
PR:Q9Z351-12
mKCNQ2/iso:12
enablesGO:0005516 calmodulin binding PMID:12223552
located_inGO:0008076 voltage-gated potassium channel complex PMID:12223552
GO:0009986 cell surface PMID:12223552
PR:Q9Z351-9
mKCNQ2/iso:9
potassium voltage-gated channel subfamily KQT member 2 isoform MKQT2.9 (mouse)
enablesNOT GO:0022832 voltage-gated channel activity PMID:9666519