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Protein Ontology report - potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant S672R (human) PR:000000760 - http://purl.obolibrary.org/obo/PR_000000760        Annotations       Ontology Information Show OBO stanza / PAF / GPI   PRO ID PR:000000760      PRO name potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant S672R (human)    Synonyms PRO-Short-label: EXACT: hHCN4/var:S672R PRO-proteoform-std: EXACT: UniProtKB:Q9Y3Q4, Ser-672, CHEBI:29952 Other: EXACT: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 2 (human)   Definition "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human) that has an Arg residue at the position equivalent to Ser-672 of the amino acid sequence represented by UniProtKB:Q9Y3Q4. UniProtKB:Q9Y3Q4, Ser-672, CHEBI:29952." [PMID:16407510, PRO:CNA, PRO:DAN]    Comment Note: This residue is located in the CNBD.    PRO Category organism-sequence    Parent PR:Q9Y3Q4   Taxon NCBITaxon:9606 Homo sapiens   Term Hierarchy   Visualization DAG: OLS: Back to top Related Cross References   Db identifiers UniProtKB_VAR:VAR_026535 Back to top Functional Annotation (PRO-centric view) Switch to GO Centric View    PRO Term GO Annotation Evidence PR:000000760 hHCN4/var:S672R UniProtKB:Q9Y3Q4, Ser-672, CHEBI:29952 | potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 2 (human) associated_with_disease_progression DO:13884 sick sinus syndrome PMID:16407510 enables GO:0005222 intracellular cAMP-activated cation channel activity PMID:16407510 altered GO:0022843 voltage-gated monoatomic cation channel activity relative to PR:000002604 HCN4/iso:1/UnMod PMID:16407510