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Protein Ontology report - voltage-gated potassium channel KCND2
PR:000000785 - http://purl.obolibrary.org/obo/PR_000000785
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000785   
  PRO namevoltage-gated potassium channel KCND2 
  Synonyms
PRO-Short-label: EXACT:KCND2
Gene-based: RELATED:KIAA1044
Other: EXACT:voltage-gated potassium channel subunit Kv4.2
  Definition"A shal-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCND2 gene or a 1:1 ortholog thereof. Kv4.2 potassium channels play a critical role in postsynaptic excitability. They are modulated by phosphorylation as well as by association with Kv4 Channel Interacting Proteins (KChIPs). The N terminus contains an ER retention motif RKR that seems to be masked when associated to KChiPs. This masking increases surface expression." [PMID:12829703, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000710
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:553
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000785 voltage-gated potassium channel KCND2, KCND2


organism-gene



PR:Q5VSI1 uncharacterized protein, kcnd2 translation product (zebrafish), z-KCND2


organism-gene



PR:Q9NZV8 potassium voltage-gated channel subfamily D member 2 (human), hKCND2


organism-sequence



PR:Q9NZV8-1 potassium voltage-gated channel subfamily D member 2 isoform 1 (human), hKCND2/iso:1

Yes

organism-modification



PR:000084839 potassium voltage-gated channel subfamily D member 2 deaminated 1 (human), hKCND2/Deam:1


organism-gene



PR:Q9Z0V2 potassium voltage-gated channel subfamily D member 2 (mouse), mKCND2


organism-sequence



PR:Q9Z0V2-1 potassium voltage-gated channel subfamily D member 2 isoform 1 (mouse), mKCND2/iso:1

Yes

organism-modification



PR:000036577 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 (mouse), mKCND2/iso:1/Phos:1


organism-modification



PR:000036578 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 (mouse), mKCND2/iso:1/Phos:2

Yes

organism-modification



PR:000036579 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 (mouse), mKCND2/iso:1/Phos:3

Yes

organism-modification



PR:000036580 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 (mouse), mKCND2/iso:1/Phos:4

Yes

organism-modification



PR:000045389 voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 3 (mouse), mKCND2/iso:1/UnPhos:3

Yes

organism-modification



PR:000045390 voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 4 (mouse), mKCND2/iso:1/UnPhos:4

Yes

sequence



PR:000000947 voltage-gated potassium channel KCND2 isoform 1, KCND2/iso:1


organism-sequence



PR:Q9NZV8-1 potassium voltage-gated channel subfamily D member 2 isoform 1 (human), hKCND2/iso:1

Yes

organism-sequence



PR:Q9Z0V2-1 potassium voltage-gated channel subfamily D member 2 isoform 1 (mouse), mKCND2/iso:1

Yes

organism-modification



PR:000036577 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 (mouse), mKCND2/iso:1/Phos:1


organism-modification



PR:000036578 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 (mouse), mKCND2/iso:1/Phos:2

Yes

organism-modification



PR:000036579 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 (mouse), mKCND2/iso:1/Phos:3

Yes

organism-modification



PR:000036580 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 (mouse), mKCND2/iso:1/Phos:4

Yes

organism-modification



PR:000045389 voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 3 (mouse), mKCND2/iso:1/UnPhos:3

Yes

organism-modification



PR:000045390 voltage-gated potassium channel KCND2 isoform 1 unphosphorylated 4 (mouse), mKCND2/iso:1/UnPhos:4

Yes

modification



PR:000000988 voltage-gated potassium channel KCND2 isoform 1 phosphorylated form, KCND2/iso:1/PhosRes+


modification



PR:000000994 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1, KCND2/iso:1/Phos:1


organism-modification



PR:000036577 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 1 (mouse), mKCND2/iso:1/Phos:1


modification



PR:000000995 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2, KCND2/iso:1/Phos:2


organism-modification



PR:000036578 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 2 (mouse), mKCND2/iso:1/Phos:2

Yes

modification



PR:000000996 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3, KCND2/iso:1/Phos:3


organism-modification



PR:000036579 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 3 (mouse), mKCND2/iso:1/Phos:3

Yes

modification



PR:000000997 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4, KCND2/iso:1/Phos:4


organism-modification



PR:000036580 voltage-gated potassium channel KCND2 isoform 1 phosphorylated 4 (mouse), mKCND2/iso:1/Phos:4

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036578
mKCND2/iso:1/Phos:2
UniProtKB:Q9Z0V2-1, Thr-38, MOD:00047
located_inGO:0030425 dendrite PMID:11040264
PR:000036579
mKCND2/iso:1/Phos:3
UniProtKB:Q9Z0V2-1, Ser-552, MOD:00046
located_inGO:0030425 dendrite PMID:11040264
PR:000036580
mKCND2/iso:1/Phos:4
UniProtKB:Q9Z0V2-1, Thr-602/Thr-607, MOD:00047|Ser-616, MOD:00046
enablesdecreased|contributes_to GO:0005250 A-type (transient outward) potassium channel activity relative to PR:000002656 PMID:16251476
located_inGO:0009986 cell surface PMID:16251476
GO:0030425 dendrite PMID:11040264
PR:000045389
mKCND2/iso:1/UnPhos:3
UniProtKB:Q9Z0V2-1, Ser-552, PR:000026291
located_inGO:0009986 cell surface PMID:12829703; PMID:16251476
PR:000045390
mKCND2/iso:1/UnPhos:4
UniProtKB:Q9Z0V2-1, Thr-602/Thr-607/Ser-616, PR:000026291
enablescontributes_to GO:0005250 A-type (transient outward) potassium channel activity PMID:16251476
PR:Q9NZV8-1
hKCND2/iso:1
acts_upstream_of_or_withinGO:0001508 action potential PMID:11102480
GO:0007268 chemical synaptic transmission PMID:11102480
located_inGO:0009986 cell surface PMID:12493773
PR:Q9Z0V2-1
mKCND2/iso:1
located_inGO:0005783 endoplasmic reticulum PMID:12829703