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Protein Ontology report - voltage-gated potassium channel subunit KCNQ2 isoform 6
PR:000000903 - http://purl.obolibrary.org/obo/PR_000000903
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000903   
  PRO namevoltage-gated potassium channel subunit KCNQ2 isoform 6 
  Synonyms
PRO-Short-label: EXACT:KCNQ2/iso:6
Other: RELATED:HNSPC
  Definition"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43526-6 or a 1:1 ortholog thereof." [PMID:9039501, PRO:CNA, PRO:DAN] 
  CommentNote: Inclusion of isoform 6 in heteromultimers results in attenuation of potassium current. Prominent expression of isoform 6 in the developing brain may alter firing repertoires of immature neurons excitability to provide cues for proliferation rather than differentiation. 
  PRO Categorysequence 
  ParentPR:000000729 voltage-gated potassium channel subunit KCNQ2
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?
sequence



PR:000000903 voltage-gated potassium channel subunit KCNQ2 isoform 6, KCNQ2/iso:6


organism-sequence



PR:O43526-6 potassium voltage-gated channel subfamily KQT member 2 isoform 6 (human), hKCNQ2/iso:6

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:O43526-6 hKCNQ2/iso:6
potassium voltage-gated channel subfamily KQT member 2 isoform HNSPC (human)
"A voltage-gated potassium channel subunit KCNQ2 isoform 6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]
enablesdecreased|contributes_to GO:0005249 voltage-gated potassium channel activity relative to PR:000002632 KCNQ2/iso:2/UnMod PMID:9039501