Home
|
Linked Open Data
|
Browse
|
Search
|
Statistics
|
Download
RACE-PRO
PRO tracker
Community
PRO Consortium
Publications
Documentation
Protein Ontology report - cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1
PR:000000981 -
http://purl.obolibrary.org/obo/PR_000000981
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000981
PRO name
cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1
Synonyms
PRO-Short-label
:
EXACT:
CNGA1/iso:1/Phos:1
Definition
"A cGMP-gated cation channel alpha-1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the VYSPGD motif located at the N terminus of the cyclic-nucleotide binding domain (CNDB). Example:
UniProtKB:Q00194-1
, Tyr-498,
MOD:00048
." [
PMID:10366613
,
PMID:14602825
]
Comment
Note: This phosphorylation prevents Ca2+/CaM inhibition of the CNG channel, but at the same time decreases the apparent affinity for cGMP.
PRO Category
modification
Parent
PR:000000932
cGMP-gated cation channel alpha-1 isoform 1 phosphorylated form
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
Back to top
Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000000981
cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1, CNGA1/iso:1/Phos:1
organism-modification
PR:000036569
cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1 (cow), cow-CNGA1/iso:1/Phos:1
Yes
Back to top
Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036569
cow-CNGA1/iso:1/Phos:1
UniProtKB:Q00194-1, Tyr-498, MOD:00048
"A cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1 in cow. UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825, PRO:CNA]
enables
decreased
GO:0030553
cGMP binding
relative to
PR:000002593
PMID:10366613
