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Protein Ontology report - myeloid differentiation primary response protein MyD88
PR:000001740 - http://purl.obolibrary.org/obo/PR_000001740
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001740   
  PRO namemyeloid differentiation primary response protein MyD88 
  Synonyms
PRO-Short-label: EXACT:MYD88
  Definition"A protein that is a translation product of the human MYD88 gene or a 1:1 ortholog thereof. This protein is an adapter involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response." [PMID:9575168, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 6                                        
         Sequence2                                                  Organism-Sequence 11                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037756
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001740 myeloid differentiation primary response protein MyD88, MYD88

Yes
organism-gene


PR:A5HNF6 myeloid differentiation primary response protein MyD88 (chicken), chick-MYD88

Yes
organism-gene


PR:P22366 myeloid differentiation primary response protein MyD88 (mouse), mMYD88

organism-sequence


PR:P22366-1 myeloid differentiation primary response protein MyD88 isoform 1 (mouse), mMYD88/iso:1

Yes
organism-sequence


PR:P22366-2 myeloid differentiation primary response protein MyD88 isoform 2 (mouse), mMYD88/iso:2
Yes
Yes
organism-gene


PR:Q5XJ85 myeloid differentiation primary response protein MyD88 (zebrafish), z-MYD88

organism-gene


PR:Q6Y1S1 myeloid differentiation primary response protein MyD88 (rat), rMYD88

organism-gene


PR:Q7K105 LD20892p (fruit fly), fly-MYD88

organism-gene


PR:Q99836 myeloid differentiation primary response protein MyD88 (human), hMYD88

Yes
organism-sequence


PR:000001742 myeloid differentiation primary response protein MyD88 sequence variant L93P (human), hMYD88/var:L93P

organism-sequence


PR:000001743 myeloid differentiation primary response protein MyD88 sequence variant R196C (human), hMYD88/var:R196C

organism-sequence


PR:000061325 myeloid differentiation primary response protein MyD88 sequence variant S34Y (human), hMYD88/var:S34Y

organism-sequence


PR:Q99836-1 myeloid differentiation primary response protein MyD88 isoform 1 (human), hMYD88/iso:1

Yes
organism-sequence


PR:Q99836-2 myeloid differentiation primary response protein MyD88 isoform 2 (human), hMYD88/iso:2

organism-sequence


PR:Q99836-3 myeloid differentiation primary response protein MyD88 isoform h3 (human), hMYD88/iso:h3

organism-sequence


PR:Q99836-4 myeloid differentiation primary response protein MyD88 isoform h4 (human), hMYD88/iso:h4

organism-sequence


PR:Q99836-5 myeloid differentiation primary response protein MyD88 isoform h5 (human), hMYD88/iso:h5

organism-sequence


PR:Q99836-6 myeloid differentiation primary response protein MyD88 isoform h6 (human), hMYD88/iso:h6

organism-modification


PR:000065926 myeloid differentiation primary response protein MyD88 methylated 1 (human), hMYD88/Me:1

organism-modification


PR:000078147 myeloid differentiation primary response protein MyD88 cysteinylated 1 (human), hMYD88/Cyst:1

organism-modification


PR:000082882 myeloid differentiation primary response protein MyD88 cysteinylated 2 (human), hMYD88/Cyst:2

sequence


PR:000001741 myeloid differentiation primary response protein MyD88 isoform 1, MYD88/iso:1

organism-sequence


PR:P22366-1 myeloid differentiation primary response protein MyD88 isoform 1 (mouse), mMYD88/iso:1

Yes
organism-sequence


PR:Q99836-1 myeloid differentiation primary response protein MyD88 isoform 1 (human), hMYD88/iso:1

Yes
sequence


PR:000024846 myeloid differentiation primary response protein MyD88 isoform 2, MYD88/iso:2

organism-sequence


PR:P22366-2 myeloid differentiation primary response protein MyD88 isoform 2 (mouse), mMYD88/iso:2
Yes
Yes
organism-sequence


PR:Q99836-2 myeloid differentiation primary response protein MyD88 isoform 2 (human), hMYD88/iso:2

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MYD88 forms found in complexes   

MYD88 Component
 Complexes
PR:000001740 MYD88 PR:000025784 MYD88:TIRAP:activated TLR4 receptor
PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex
PR:A5HNF6 chick-MYD88 PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)
PR:P22366ZDASHZ1 mMYD88/iso:1 PR:000027175 MYD88l:TIRAP:activated TLR4 receptor (mouse)
PR:000027187 IRAK4:MYD88:TIRAP:activated TLR4 complex (mouse)
PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000037481 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:P22366ZDASHZ2 mMYD88/iso:2 PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse)
PR:Q99836 hMYD88 PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:Q99836ZDASHZ1 hMYD88/iso:1 PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P22366-2 mMYD88/iso:2

"A myeloid differentiation primary response protein MyD88 isoform 2 that is encoded in the genome of mouse." [PMID:11909531, PRO:CNA]		 acts_upstream_of_or_withinGO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PMID:12538665