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Protein Ontology report - TIR domain-containing adapter molecule 1
PR:000001749 - http://purl.obolibrary.org/obo/PR_000001749
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001749   
  PRO nameTIR domain-containing adapter molecule 1 
  Synonyms
PRO-Short-label: EXACT:TICAM1
Gene-based: RELATED:PRVTIRB | TRIF
Other: EXACT:proline-rich, vinculin and TIR domain-containing protein B | putative NF-kappa-B-activating protein 502H | TICAM-1 | TIR domain-containing adapter protein inducing IFN-beta | Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
  Definition"A protein that is a translation product of the human TICAM1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037744
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001749 TIR domain-containing adapter molecule 1, TICAM1

organism-gene


PR:A0FKC7 Toll/IL-1 recepter (TIR)-domain containing adapter inducing interferon beta (chicken), chick-TICAM1
Yes
Yes
organism-gene


PR:Q80UF7 TIR domain-containing adapter molecule 1 (mouse), mTICAM1

Yes
organism-gene


PR:Q8IUC6 TIR domain-containing adapter molecule 1 (human), hTICAM1

Yes
organism-sequence


PR:000062592 TIR domain-containing adapter molecule 1 sequence variant R141* (human), hTICAM1/var:R141*

organism-modification


PR:000080416 TIR domain-containing adapter molecule 1 methylated 1 (human), hTICAM1/Me:1

organism-modification


PR:000081831 TIR domain-containing adapter molecule 1 deaminated 1 (human), hTICAM1/Deam:1

modification


PR:000028676 TIR domain-containing adapter molecule 1 phosphorylated form, TICAM1/PhosRes+

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TICAM1 forms found in complexes   

TICAM1 Component
 Complexes
PR:A0FKC7 chick-TICAM1 PR:000037462 ticam1:viral dsRNA:TLR3 complex (chicken)
PR:Q80UF7 mTICAM1 PR:000027207 ticam1:ticam2:activated TLR4 complex (mouse)
PR:000028683 traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036095 K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036097 tbk1:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036099 ikke:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000037308 ticam1:viral dsRNA:TLR3 complex (mouse)
PR:000037311 traf3:ticam1:activated TLR3 complex (mouse)
PR:000037313 tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)
PR:000037471 traf6:ticam1:activated TLR3 complex (mouse)
PR:Q8IUC6 hTICAM1 PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)
PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)
PR:000037310 traf3:ticam1:activated TLR3 complex (human)
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037330 SARM:ticam1:activated TLR3 complex (human)
PR:000037332 rip3:ticam1:activated TLR3 complex (human)
PR:000037334 rip1:ticam1:activated TLR3 complex (human)
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037344 traf6:ticam1:activated TLR3 complex (human)
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:A0FKC7 chick-TICAM1

"A TIR domain-containing adapter molecule 1 that is encoded in the genome of chicken." [PMID:17676477, PRO:CNA, Reactome:R-GGA-433866]		 located_inGO:0005829 cytosol Reactome:REACT_26995