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PRO ID
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| PRO name | nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated 2 |
| Synonyms | | PRO-Short-label: | EXACT: | NFKB1/iso:2/Phos:2 |
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| Definition | "A nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form that has been pre-phosphorylated by GSK-3 beta (PR:000001760) followed by phosphorylation of the two Ser residues within the conserved motif DSGVETS in the PEST region. Phosphorylation occurs after the stimulation of cells with proinflammatory cytokines, such as tumor necrosis factor or interleukin-1. This phosphorylation results in accelerated nuclear factor NF-kappa-B p105 degradation. Example: UniProtKB:P19838-1, Ser-903/Ser-907/Ser-927/Ser-932, MOD:00046." [PMID:12482991, PMID:12871932] |
| PRO Category | modification |
| Parent | PR:000001759 nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form
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