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Protein Ontology report - inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits
PR:000001774 - http://purl.obolibrary.org/obo/PR_000001774
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001774   
  PRO nameinhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits 
  Definition"A protein with core domain architecture consisting of an N-terminal Protein kinase domain (Pfam:PF00069), and a C-terminus that is involved in the interaction with NEMO (PR:000001752). In response to a large variety of stimuli, among them pro-inflammatory cytokines, growth factors and microbial pathogens, signals emanating from cell surface receptors converge at the IkappaB kinase (IKK) complex. This complex is composed of four subunits, IKKalpha, IKKbeta, ELK, and NEMO. IKKbeta and NEMO subunits are known to be essential for activating NF-kappaB. Activation of NF-kappaB dimers is the result of IKK-mediated, phosphorylation-induced degradation of the IkappaB inhibitor, which enables the NF-kappaB dimers to enter the nucleus and activate specific target gene expression." [PIRSF:PIRSF000581, PMID:10359587, PMID:18462684, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 9                                        
         Sequence1                                                  Organism-Sequence 9                                        
         Modification2                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF000581
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000001774 inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits, LBP

gene


PR:000001775 inhibitor of nuclear factor kappa-B kinase subunit alpha, CHUK

organism-gene


PR:O15111 inhibitor of nuclear factor kappa-B kinase subunit alpha (human), hCHUK

Yes
organism-sequence


PR:O15111-1 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (human), hCHUK/iso:1

organism-modification


PR:000026823 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (human), hCHUK/iso:1/Phos:1

Yes
organism-modification


PR:000045576 inhibitor of nuclear factor kappa-B kinase subunit alpha phosphorylated 2 (human), hCHUK/Phos:2

organism-modification


PR:000062311 inhibitor of nuclear factor kappa-B kinase subunit alpha phosphorylated 1 (human), hCHUK/Phos:1

organism-modification


PR:000065276 inhibitor of nuclear factor kappa-B kinase subunit alpha methylated 1 (human), hCHUK/Me:1

organism-modification


PR:000085410 inhibitor of nuclear factor kappa-B kinase subunit alpha deaminated 1 (human), hCHUK/Deam:1

organism-gene


PR:Q4G3H4 inhibitor of nuclear factor kappa-B kinase subunit alpha (zebrafish), z-CHUK

organism-gene


PR:Q5ZJB4 inhibitor of nuclear factor kappa-B kinase subunit alpha (chicken), chick-CHUK

organism-gene


PR:Q60680 inhibitor of nuclear factor kappa-B kinase subunit alpha (mouse), mCHUK

organism-sequence


PR:Q60680-1 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (mouse), mCHUK/iso:1

Yes
organism-modification


PR:000036121 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (mouse), mCHUK/iso:1/Phos:1

Yes
organism-sequence


PR:Q60680-2 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform m2 (mouse), mCHUK/iso:m2

organism-sequence


PR:Q60680-3 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform m3 (mouse), mCHUK/iso:m3

sequence


PR:000026820 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1, CHUK/iso:1

organism-sequence


PR:O15111-1 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (human), hCHUK/iso:1

organism-modification


PR:000026823 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (human), hCHUK/iso:1/Phos:1

Yes
organism-sequence


PR:Q60680-1 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (mouse), mCHUK/iso:1

Yes
organism-modification


PR:000036121 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (mouse), mCHUK/iso:1/Phos:1

Yes
modification


PR:000026822 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1, CHUK/iso:1/Phos:1

organism-modification


PR:000026823 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (human), hCHUK/iso:1/Phos:1

Yes
organism-modification


PR:000036121 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (mouse), mCHUK/iso:1/Phos:1

Yes
gene


PR:000001776 inhibitor of nuclear factor kappa-B kinase subunit beta, IKBKB

organism-gene


PR:O14920 inhibitor of nuclear factor kappa-B kinase subunit beta (human), hIKBKB

Yes
organism-sequence


PR:O14920-1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform h1 (human), hIKBKB/iso:h1

organism-sequence


PR:O14920-2 inhibitor of nuclear factor kappa-B kinase subunit beta isoform h2 (human), hIKBKB/iso:h2

organism-sequence


PR:O14920-3 inhibitor of nuclear factor kappa-B kinase subunit beta isoform h3 (human), hIKBKB/iso:h3

organism-sequence


PR:O14920-4 inhibitor of nuclear factor kappa-B kinase subunit beta isoform h4 (human), hIKBKB/iso:h4

organism-modification


PR:000035831 inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 (human), hIKBKB/Phos:1

Yes
organism-modification


PR:000077358 inhibitor of nuclear factor kappa-B kinase subunit beta deaminated 1 (human), hIKBKB/Deam:1

organism-gene


PR:O88351 inhibitor of nuclear factor kappa-B kinase subunit beta (mouse), mIKBKB

Yes
organism-modification


PR:000036115 inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 (mouse), mIKBKB/Phos:1

Yes
organism-gene


PR:Q5ZI83 uncharacterized protein, RCJMB04_29g15 translation product (chicken), chick-IKBKB

organism-gene


PR:Q84M95 probable serine/threonine-protein kinase PBL28 (Arabidopsis thaliana), At-IKBKB

organism-sequence


PR:Q84M95-1 probable serine/threonine-protein kinase PBL28 isoform 1 (Arabidopsis thaliana), At-IKBKB/iso:1

organism-gene


PR:Q9QY78 inhibitor of nuclear factor kappa-B kinase subunit beta (rat), rIKBKB

modification


PR:000035830 inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1, IKBKB/Phos:1

organism-modification


PR:000035831 inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 (human), hIKBKB/Phos:1

Yes
organism-modification


PR:000036115 inhibitor of nuclear factor kappa-B kinase subunit beta phosphorylated 1 (mouse), mIKBKB/Phos:1

Yes
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LBP forms found in complexes   

LBP Component
 Complexes
PR:000026823 hCHUK/iso:1/Phos:1 PR:000035833 activated IkappaB kinase complex (human)
PR:000035831 hIKBKB/Phos:1 PR:000035833 activated IkappaB kinase complex (human)
PR:000036115 mIKBKB/Phos:1 PR:000036119 activated IkappaB kinase complex (mouse)
PR:000036121 mCHUK/iso:1/Phos:1 PR:000036119 activated IkappaB kinase complex (mouse)
PR:O14920 hIKBKB PR:000026457 IkappaB kinase complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:O15111 hCHUK PR:000026457 IkappaB kinase complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:O88351 mIKBKB PR:000036118 IkappaB kinase complex (mouse)
PR:Q60680ZDASHZ1 mCHUK/iso:1 PR:000036118 IkappaB kinase complex (mouse)