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Protein Ontology report - inhibitor of nuclear factor kappa-B kinase subunit epsilon
PR:000001778 - http://purl.obolibrary.org/obo/PR_000001778
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001778   
  PRO nameinhibitor of nuclear factor kappa-B kinase subunit epsilon 
  Synonyms
PRO-Short-label: EXACT:IKBKE
Gene-based: RELATED:IKKE | IKKI | KIAA0151
Other: EXACT:I-kappa-B kinase epsilon | IkBKE | IKK-E | IKK-epsilon | IKK-i | inducible I kappa-B kinase
  Definition"An IKK-related kinase that is a translation product of the human IKBKE gene or a 1:1 ortholog thereof. Members of this class are part of the PMA-inducible IkappaB kinase complex." [PMID:10882136, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000001777 IKK-related kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2040
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001778 inhibitor of nuclear factor kappa-B kinase subunit epsilon, IKBKE

organism-gene


PR:Q14164 inhibitor of nuclear factor kappa-B kinase subunit epsilon (human), hIKBKE

organism-sequence


PR:Q14164-1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1 (human), hIKBKE/iso:1

organism-sequence


PR:Q14164-2 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform h2 (human), hIKBKE/iso:h2

organism-modification


PR:000028691 inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1 (human), hIKBKE/Phos:1

Yes
organism-modification


PR:000064755 inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated and sumoylated 1 (human), hIKBKE/PhosSumo:1

organism-gene


PR:Q9R0T8 inhibitor of nuclear factor kappa-B kinase subunit epsilon (mouse), mIKBKE

Yes
sequence


PR:000028688 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1, IKBKE/iso:1

organism-sequence


PR:Q14164-1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1 (human), hIKBKE/iso:1

modification


PR:000028690 inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1, IKBKE/Phos:1

organism-modification


PR:000028691 inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1 (human), hIKBKE/Phos:1

Yes
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IKBKE forms found in complexes   

IKBKE Component
 Complexes
PR:000028691 hIKBKE/Phos:1 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q9R0T8 mIKBKE PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036099 ikke:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036149 tbk1:tank:ikke complex (mouse)
PR:000037313 tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)