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Protein Ontology report - interleukin-1 receptor-associated kinase IRAK1/3
PR:000001781 - http://purl.obolibrary.org/obo/PR_000001781
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001781   
  PRO nameinterleukin-1 receptor-associated kinase IRAK1/3 
  Definition"A protein with core domain architecture consisting of an N-terminal Death domain (Pfam:PF00531) followed by a Protein kinase domain (Pfam:PF00069). This class is closely related to IRAK-4 (PR:000001780), but it contains an extra C-terminal region of about 200 residues." [PMID:12620219] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 9                                        
         Sequence2                                                  Organism-Sequence 14                                        
         Modification5                                                  Organism-Modification 17                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038190
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000001781 interleukin-1 receptor-associated kinase IRAK1/3, IRAK4

gene


PR:000001782 interleukin-1 receptor-associated kinase 1, IRAK1

organism-gene


PR:P51617 interleukin-1 receptor-associated kinase 1 (human), hIRAK1

organism-sequence


PR:P51617-1 interleukin-1 receptor-associated kinase 1 isoform 1 (human), hIRAK1/iso:1
Yes
organism-modification


PR:000027492 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human), hIRAK1/iso:1/Phos:3
Yes
organism-modification


PR:000027493 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human), hIRAK1/iso:1/Phos:4
Yes
organism-modification


PR:000027494 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human), hIRAK1/iso:1/Phos:1
Yes
Yes
organism-modification


PR:000061935 interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human), hIRAK1/iso:1/pSerThr+

organism-sequence


PR:P51617-2 interleukin-1 receptor-associated kinase 1 isoform h2 (human), hIRAK1/iso:h2

organism-sequence


PR:P51617-3 interleukin-1 receptor-associated kinase 1 isoform h3 (human), hIRAK1/iso:h3

organism-sequence


PR:P51617-4 interleukin-1 receptor-associated kinase 1 isoform h4 (human), hIRAK1/iso:h4

organism-modification


PR:000048042 interleukin-1 receptor-associated kinase 1 phosphorylated 5 (human), hIRAK1/Phos:5

organism-modification


PR:000048043 interleukin-1 receptor-associated kinase 1 phosphorylated 1 (human), hIRAK1/Phos:1

organism-modification


PR:000048044 interleukin-1 receptor-associated kinase 1 phosphorylated 3 (human), hIRAK1/Phos:3

organism-modification


PR:000062298 interleukin-1 receptor-associated kinase 1 phosphorylated 2 (human), hIRAK1/Phos:2

organism-modification


PR:000064197 interleukin-1 receptor-associated kinase 1 phosphoserine and phosphothreonine form (human), hIRAK1/pSerThr+

organism-modification


PR:000064772 interleukin-1 receptor-associated kinase 1 phosphorylated and ubiquitinated 1 (human), hIRAK1/PhosUbiq:1

organism-gene


PR:Q62406 interleukin-1 receptor-associated kinase 1 (mouse), mIRAK1

Yes
organism-sequence


PR:Q62406-1 interleukin-1 receptor-associated kinase 1 isoform 1 (mouse), mIRAK1/iso:1

organism-modification


PR:000027178 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse), mIRAK1/iso:1/Phos:1

Yes
organism-modification


PR:000027179 interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse), mIRAK1/iso:1/UnMod

Yes
organism-sequence


PR:Q62406-2 interleukin-1 receptor-associated kinase 1 isoform m2 (mouse), mIRAK1/iso:m2

sequence


PR:000021973 interleukin-1 receptor-associated kinase 1 isoform 1, IRAK1/iso:1

organism-sequence


PR:P51617-1 interleukin-1 receptor-associated kinase 1 isoform 1 (human), hIRAK1/iso:1
Yes
organism-modification


PR:000027492 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human), hIRAK1/iso:1/Phos:3
Yes
organism-modification


PR:000027493 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human), hIRAK1/iso:1/Phos:4
Yes
organism-modification


PR:000027494 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human), hIRAK1/iso:1/Phos:1
Yes
Yes
organism-modification


PR:000061935 interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human), hIRAK1/iso:1/pSerThr+

organism-sequence


PR:Q62406-1 interleukin-1 receptor-associated kinase 1 isoform 1 (mouse), mIRAK1/iso:1

organism-modification


PR:000027178 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse), mIRAK1/iso:1/Phos:1

Yes
organism-modification


PR:000027179 interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse), mIRAK1/iso:1/UnMod

Yes
modification


PR:000021971 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form, IRAK1/iso:1/PhosRes+

modification


PR:000021975 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1, IRAK1/iso:1/Phos:1

organism-modification


PR:000027178 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse), mIRAK1/iso:1/Phos:1

Yes
organism-modification


PR:000027494 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human), hIRAK1/iso:1/Phos:1
Yes
Yes
modification


PR:000021977 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3, IRAK1/iso:1/Phos:3

organism-modification


PR:000027492 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human), hIRAK1/iso:1/Phos:3
Yes
modification


PR:000021978 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4, IRAK1/iso:1/Phos:4

organism-modification


PR:000027493 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human), hIRAK1/iso:1/Phos:4
Yes
organism-modification


PR:000061935 interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human), hIRAK1/iso:1/pSerThr+

modification


PR:000021974 interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form, IRAK1/iso:1/UnMod

organism-modification


PR:000027179 interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse), mIRAK1/iso:1/UnMod

Yes
gene


PR:000001783 interleukin-1 receptor-associated kinase-like 2, IRAK2

organism-gene


PR:F1N826 uncharacterized protein, IRAK2 translation product (chicken), chick-IRAK2

organism-gene


PR:O43187 interleukin-1 receptor-associated kinase-like 2 (human), hIRAK2

organism-modification


PR:000048045 interleukin-1 receptor-associated kinase-like 2 phosphorylated form (human), hIRAK2/PhosRes+

organism-modification


PR:000081167 interleukin-1 receptor-associated kinase-like 2 cysteinylated 1 (human), hIRAK2/Cyst:1

organism-modification


PR:000081833 interleukin-1 receptor-associated kinase-like 2 cysteinylated 2 (human), hIRAK2/Cyst:2

organism-modification


PR:000082521 interleukin-1 receptor-associated kinase-like 2 cysteinylated 3 (human), hIRAK2/Cyst:3

organism-gene


PR:Q4QQS0 interleukin-1 receptor-associated kinase-like 2 (rat), rIRAK2

organism-gene


PR:Q8CFA1 interleukin-1 receptor-associated kinase-like 2 (mouse), mIRAK2

organism-sequence


PR:Q8CFA1-1 interleukin-1 receptor-associated kinase-like 2 isoform m1 (mouse), mIRAK2/iso:m1

organism-sequence


PR:Q8CFA1-2 interleukin-1 receptor-associated kinase-like 2 isoform m2 (mouse), mIRAK2/iso:m2

organism-sequence


PR:Q8CFA1-3 interleukin-1 receptor-associated kinase-like 2 isoform m3 (mouse), mIRAK2/iso:m3

organism-sequence


PR:Q8CFA1-4 interleukin-1 receptor-associated kinase-like 2 isoform m4 (mouse), mIRAK2/iso:m4

gene


PR:000001784 interleukin-1 receptor-associated kinase 3, IRAK3

organism-gene


PR:G5ECP4 pelle-like serine/threonine-protein kinase pik-1 (worm), IRAK3 (worm)

organism-sequence


PR:G5ECP4-1 pelle-like serine/threonine-protein kinase pik-1 isoform a (worm), IRAK3/iso:a (worm)

organism-sequence


PR:G5ECP4-2 pelle-like serine/threonine-protein kinase pik-1 isoform b (worm), IRAK3/iso:b (worm)

organism-gene


PR:Q8K4B2 interleukin-1 receptor-associated kinase 3 (mouse), mIRAK3
Yes
Yes
organism-gene


PR:Q9Y616 interleukin-1 receptor-associated kinase 3 (human), hIRAK3

organism-sequence


PR:Q9Y616-1 interleukin-1 receptor-associated kinase 3 isoform 1 (human), hIRAK3/iso:1
Yes
organism-sequence


PR:Q9Y616-2 interleukin-1 receptor-associated kinase 3 isoform h2 (human), hIRAK3/iso:h2

organism-modification


PR:000073219 interleukin-1 receptor-associated kinase 3 phosphorylated 1 (human), hIRAK3/Phos:1

sequence


PR:000027241 interleukin-1 receptor-associated kinase 3 isoform 1, IRAK3/iso:1

organism-sequence


PR:Q9Y616-1 interleukin-1 receptor-associated kinase 3 isoform 1 (human), hIRAK3/iso:1
Yes
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IRAK4 forms found in complexes   

IRAK4 Component
 Complexes
PR:000027178 mIRAK1/iso:1/Phos:1 PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027179 mIRAK1/iso:1/UnMod PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027253 IRAK1:tollip complex (mouse)
PR:000027494 hIRAK1/iso:1/Phos:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
PR:Q62406 mIRAK1 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:Q8K4B2 mIRAK3 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027492 hIRAK1/iso:1/Phos:3
UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047 | pp-IRAK1 (human)
"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 in human. UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047." [PMID:14625308, PRO:CNA]		 acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0004674 protein serine/threonine kinase activity PMID:14625308
PR:000027493 hIRAK1/iso:1/Phos:4
UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046 | hp-IRAK1 (human)
"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 in human. UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046." [PMID:14625308, PRO:CNA]		 acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0004674 protein serine/threonine kinase activity PMID:14625308
NOT GO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308
NOT GO:0005515 protein binding PMID:14625308
PR:000027494 hIRAK1/iso:1/Phos:1
UniProtKB:P51617-1, Thr-209, MOD:00047
"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P51617-1, Thr-209, MOD:00047." [PRO:DNx, UniProtKB:P51617]		 enablesGO:0005515 protein binding with PR:Q9NWZ3 hIRAK4 PMID:11960013
GO:0016301 kinase activity PMID:11960013
PR:P51617-1 hIRAK1/iso:1
interleukin-1 receptor-associated kinase 1 isoform a (human)
"An interleukin-1 receptor-associated kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308
GO:0005515 protein binding with PR:Q9Y4K3 E3 ubiquitin-protein ligase TRAF6 (human) PMID:14625308
PR:Q8K4B2 mIRAK3
Irak3 | IL-1 receptor-associated kinase M (mouse) | inactive IL-1 receptor-associated kinase 3 (mouse) | IRAK-3 (mouse) | IRAK-M (mouse)
"An interleukin-1 receptor-associated kinase 3 that is encoded in the genome of mouse." [OMA:Q8K4B2, PMID:12150927, PRO:CNA]		 acts_upstream_of_or_withinGO:0034122 negative regulation of toll-like receptor signaling pathway PMID:12150927
PR:Q9Y616-1 hIRAK3/iso:1

"An interleukin-1 receptor-associated kinase 3 isoform 1 that is encoded in the genome of human." [GenBank:AF113136, PMID:10383454, PRO:CNA]		 acts_upstream_of_or_withinGO:0034122 negative regulation of toll-like receptor signaling pathway PMID:10383454
enablesGO:0005515 protein binding with PR:Q99836 hMYD88 PMID:10383454