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Protein Ontology report - caspase-8-like protease
PR:000002197 - http://purl.obolibrary.org/obo/PR_000002197
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000002197   
  PRO namecaspase-8-like protease 
  Definition"A protein that is a translation product of the human CASP8, CASP10, or CFLAR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The core domain architecture consists of two consecutive copies of the Death effector domain (DED) domain (Pfam:PF01335) in an amino-terminal propeptide followed by Peptidase_C14 domain (Pfam:PF00656). Encoded as zymogens, the activated proteins are cysteine proteases typically involved in apoptosis." [PRO:DAN, PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 6                                        
         Sequence13                                                  Organism-Sequence 34                                        
         Modification4                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037643
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000002197 caspase-8-like protease, APAF1

gene


PR:000002282 CASP8 and FADD-like apoptosis regulator, CFLAR

organism-gene


PR:O15519 CASP8 and FADD-like apoptosis regulator (human), hCFLAR

organism-sequence


PR:O15519-1 CASP8 and FADD-like apoptosis regulator isoform h1 (human), hCFLAR/iso:h1

organism-modification


PR:000064786 CASP8 and FADD-like apoptosis regulator isoform h1 ubiquitinated 1 (human), hCFLAR/iso:h1/Ubiq:1

organism-sequence


PR:O15519-10 CASP8 and FADD-like apoptosis regulator isoform h10 (human), hCFLAR/iso:h10

organism-sequence


PR:O15519-11 CASP8 and FADD-like apoptosis regulator isoform h11 (human), hCFLAR/iso:h11

organism-sequence


PR:O15519-12 CASP8 and FADD-like apoptosis regulator isoform h12 (human), hCFLAR/iso:h12

organism-sequence


PR:O15519-13 CASP8 and FADD-like apoptosis regulator isoform h13 (human), hCFLAR/iso:h13

organism-sequence


PR:O15519-14 CASP8 and FADD-like apoptosis regulator isoform h14 (human), hCFLAR/iso:h14

organism-sequence


PR:O15519-15 CASP8 and FADD-like apoptosis regulator isoform h15 (human), hCFLAR/iso:h15

organism-sequence


PR:O15519-2 CASP8 and FADD-like apoptosis regulator isoform h2 (human), hCFLAR/iso:h2

organism-sequence


PR:O15519-3 CASP8 and FADD-like apoptosis regulator isoform h3 (human), hCFLAR/iso:h3

organism-sequence


PR:O15519-4 CASP8 and FADD-like apoptosis regulator isoform h4 (human), hCFLAR/iso:h4

organism-sequence


PR:O15519-5 CASP8 and FADD-like apoptosis regulator isoform h5 (human), hCFLAR/iso:h5

organism-sequence


PR:O15519-6 CASP8 and FADD-like apoptosis regulator isoform h6 (human), hCFLAR/iso:h6

organism-sequence


PR:O15519-7 CASP8 and FADD-like apoptosis regulator isoform h7 (human), hCFLAR/iso:h7

organism-sequence


PR:O15519-8 CASP8 and FADD-like apoptosis regulator isoform h8 (human), hCFLAR/iso:h8

organism-sequence


PR:O15519-9 CASP8 and FADD-like apoptosis regulator isoform h9 (human), hCFLAR/iso:h9

organism-modification


PR:000081836 CASP8 and FADD-like apoptosis regulator deaminated 1 (human), hCFLAR/Deam:1

organism-gene


PR:O35732 CASP8 and FADD-like apoptosis regulator (mouse), mCFLAR

organism-sequence


PR:O35732-1 CASP8 and FADD-like apoptosis regulator isoform m1 (mouse), mCFLAR/iso:m1

organism-sequence


PR:O35732-2 CASP8 and FADD-like apoptosis regulator isoform m2 (mouse), mCFLAR/iso:m2

gene


PR:000002310 caspase-10, CASP10

organism-gene


PR:Q92851 caspase-10 (human), hCASP10

organism-sequence


PR:Q92851-1 caspase-10 isoform A (human), hCASP10/iso:A

organism-sequence


PR:Q92851-2 caspase-10 isoform B (human), hCASP10/iso:B

organism-sequence


PR:Q92851-3 caspase-10 isoform C (human), hCASP10/iso:C

organism-sequence


PR:Q92851-4 caspase-10 isoform D (human), hCASP10/iso:D

organism-sequence


PR:Q92851-5 caspase-10 isoform h5 (human), hCASP10/iso:h5

organism-sequence


PR:Q92851-6 caspase-10 isoform h6 (human), hCASP10/iso:h6

organism-sequence


PR:Q92851-7 caspase-10 isoform h7 (human), hCASP10/iso:h7

organism-modification


PR:000077727 caspase-10 phosphorylated 1 (human), hCASP10/Phos:1

sequence


PR:000002396 caspase-10 isoform 1, CASP10/iso:1

organism-sequence


PR:Q92851-1 caspase-10 isoform A (human), hCASP10/iso:A

sequence


PR:000002397 caspase-10 isoform 2, CASP10/iso:2

organism-sequence


PR:Q92851-2 caspase-10 isoform B (human), hCASP10/iso:B

sequence


PR:000002398 caspase-10 isoform 3, CASP10/iso:3

organism-sequence


PR:Q92851-3 caspase-10 isoform C (human), hCASP10/iso:C

sequence


PR:000002399 caspase-10 isoform 4, CASP10/iso:4

organism-sequence


PR:Q92851-4 caspase-10 isoform D (human), hCASP10/iso:D

modification


PR:000018759 caspase-10 proteolytic cleavage product, CASP10/ClvPrd

gene


PR:000002317 caspase-8, CASP8

organism-gene


PR:O89110 caspase-8 (mouse), mCASP8

organism-sequence


PR:O89110-1 caspase-8 isoform 1 (mouse), mCASP8/iso:1

organism-gene


PR:Q14790 caspase-8 (human), hCASP8

Yes
organism-sequence


PR:Q14790-1 caspase-8 isoform 1 (human), hCASP8/iso:1

organism-modification


PR:000036063 caspase-8 isoform 1 cleaved 1 (human), hCASP8/iso:1/Clv:1

Yes
organism-modification


PR:000036065 caspase-8 isoform 1 cleaved 2 (human), hCASP8/iso:1/Clv:2

Yes
organism-sequence


PR:Q14790-2 caspase-8 isoform 2 (human), hCASP8/iso:2

organism-sequence


PR:Q14790-3 caspase-8 isoform 3 (human), hCASP8/iso:3

organism-sequence


PR:Q14790-4 caspase-8 isoform 4 (human), hCASP8/iso:4

organism-sequence


PR:Q14790-5 caspase-8 isoform 5 (human), hCASP8/iso:5

organism-sequence


PR:Q14790-6 caspase-8 isoform 6 (human), hCASP8/iso:6

organism-sequence


PR:Q14790-7 caspase-8 isoform 7 (human), hCASP8/iso:7

organism-sequence


PR:Q14790-8 caspase-8 isoform 8 (human), hCASP8/iso:8

organism-sequence


PR:Q14790-9 caspase-8 isoform 9 (human), hCASP8/iso:9

organism-modification


PR:000045931 caspase-8 phosphorylated 1 (human), hCASP8/Phos:1

organism-gene


PR:Q9JHX4 caspase-8 (rat), rCASP8

sequence


PR:000002412 caspase-8 isoform 1, CASP8/iso:1

organism-sequence


PR:O89110-1 caspase-8 isoform 1 (mouse), mCASP8/iso:1

organism-sequence


PR:Q14790-1 caspase-8 isoform 1 (human), hCASP8/iso:1

organism-modification


PR:000036063 caspase-8 isoform 1 cleaved 1 (human), hCASP8/iso:1/Clv:1

Yes
organism-modification


PR:000036065 caspase-8 isoform 1 cleaved 2 (human), hCASP8/iso:1/Clv:2

Yes
modification


PR:000036062 caspase-8 isoform 1 cleaved 1, CASP8/iso:1/Clv:1

organism-modification


PR:000036063 caspase-8 isoform 1 cleaved 1 (human), hCASP8/iso:1/Clv:1

Yes
modification


PR:000036064 caspase-8 isoform 1 cleaved 2, CASP8/iso:1/Clv:2

organism-modification


PR:000036065 caspase-8 isoform 1 cleaved 2 (human), hCASP8/iso:1/Clv:2

Yes
sequence


PR:000002413 caspase-8 isoform 2, CASP8/iso:2

organism-sequence


PR:Q14790-2 caspase-8 isoform 2 (human), hCASP8/iso:2

sequence


PR:000002414 caspase-8 isoform 3, CASP8/iso:3

organism-sequence


PR:Q14790-3 caspase-8 isoform 3 (human), hCASP8/iso:3

sequence


PR:000002415 caspase-8 isoform 4, CASP8/iso:4

organism-sequence


PR:Q14790-4 caspase-8 isoform 4 (human), hCASP8/iso:4

sequence


PR:000002416 caspase-8 isoform 5, CASP8/iso:5

organism-sequence


PR:Q14790-5 caspase-8 isoform 5 (human), hCASP8/iso:5

sequence


PR:000002417 caspase-8 isoform 6, CASP8/iso:6

organism-sequence


PR:Q14790-6 caspase-8 isoform 6 (human), hCASP8/iso:6

sequence


PR:000002418 caspase-8 isoform 7, CASP8/iso:7

organism-sequence


PR:Q14790-7 caspase-8 isoform 7 (human), hCASP8/iso:7

sequence


PR:000002419 caspase-8 isoform 8, CASP8/iso:8

organism-sequence


PR:Q14790-8 caspase-8 isoform 8 (human), hCASP8/iso:8

sequence


PR:000002420 caspase-8 isoform 9, CASP8/iso:9

organism-sequence


PR:Q14790-9 caspase-8 isoform 9 (human), hCASP8/iso:9

modification


PR:000018768 caspase-8 proteolytic cleavage product, CASP8/ClvPrd

modification


PR:000036062 caspase-8 isoform 1 cleaved 1, CASP8/iso:1/Clv:1

organism-modification


PR:000036063 caspase-8 isoform 1 cleaved 1 (human), hCASP8/iso:1/Clv:1

Yes
modification


PR:000036064 caspase-8 isoform 1 cleaved 2, CASP8/iso:1/Clv:2

organism-modification


PR:000036065 caspase-8 isoform 1 cleaved 2 (human), hCASP8/iso:1/Clv:2

Yes
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APAF1 forms found in complexes   

APAF1 Component
 Complexes
PR:000036063 hCASP8/iso:1/Clv:1 PR:000036068 caspase-8 complex (human)
PR:000036065 hCASP8/iso:1/Clv:2 PR:000036068 caspase-8 complex (human)
PR:Q14790 hCASP8 PR:000028435 TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human)
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)