Home
|
Linked Open Data
|
Browse
|
Search
|
Statistics
|
Download
RACE-PRO
PRO tracker
Community
PRO Consortium
Publications
Documentation
Protein Ontology report - tyrosine-protein kinase Lck isoform 1 phosphorylated 1
PR:000003001 -
http://purl.obolibrary.org/obo/PR_000003001
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000003001
PRO name
tyrosine-protein kinase Lck isoform 1 phosphorylated 1
Synonyms
PRO-Short-label
:
EXACT:
LCK/iso:1/Phos:1
Other
:
EXACT:
lck autoinhibited
Definition
"A tyrosine-protein kinase Lck isoform 1 phosphorylated form in which the phosphorylation occurs at the autoinhibitory Tyr residue (Tyr-505 in human lck), and in the activation Tyr residue (Tyr-394 in human lck). This form is predominant in the presence of HIV gp120 protein. Example:
UniProtKB:P06239-1
, Tyr-394/Tyr-505,
MOD:00048
." [
PMID:9043947
, PRO:CL, PRO:DAN]
PRO Category
modification
Parent
PR:000003000
tyrosine-protein kinase Lck isoform 1 phosphorylated form
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
Back to top
Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000003001
tyrosine-protein kinase Lck isoform 1 phosphorylated 1, LCK/iso:1/Phos:1
organism-modification
PR:000036619
tyrosine-protein kinase Lck isoform 1 phosphorylated 1 (human), hLCK/iso:1/Phos:1
Yes
Back to top
Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036619
hLCK/iso:1/Phos:1
UniProtKB:P06239-1, Tyr-394/Tyr-505, MOD:00048
"A tyrosine-protein kinase Lck isoform 1 phosphorylated 1 in human. UniProtKB:P06239-1, Tyr-394/Tyr-505, MOD:00048." [PMID:9043947, PRO:CL]
enables
decreased
GO:0016301
kinase activity
relative to
PR:000036622
hLCK/iso:1/Phos:2
PMID:9043947
