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Protein Ontology report - SYK/ZAP-70 family tyrosine-protein kinase
PR:000003063 - http://purl.obolibrary.org/obo/PR_000003063
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003063   
  PRO nameSYK/ZAP-70 family tyrosine-protein kinase 
  Synonyms
Other: EXACT:tyrosine-protein kinase, SYK/ZAP-70 type
  Definition"A protein that is a translation product of the human SYK or ZAP70 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PMID:8520027, PMID:9140060, PRO:CNA, PRO:DAN] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 7                                        
         Sequence3                                                  Organism-Sequence 11                                        
         Modification4                                                  Organism-Modification 17                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF000604
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000003063 SYK/ZAP-70 family tyrosine-protein kinase, CD247/iso:CD3 zeta/Phos:1

gene


PR:000003064 tyrosine-protein kinase ZAP-70, ZAP70

organism-gene


PR:A0A0R4J8U1 tyrosine-protein kinase (rat), rZAP70

organism-gene


PR:P43403 tyrosine-protein kinase ZAP-70 (human), hZAP70

organism-sequence


PR:P43403-1 tyrosine-protein kinase ZAP-70 isoform 1 (human), hZAP70/iso:1

organism-modification


PR:000036629 tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 (human), hZAP70/iso:1/Phos:1
Yes
organism-sequence


PR:P43403-2 tyrosine-protein kinase ZAP-70 isoform 2 (human), hZAP70/iso:2

organism-sequence


PR:P43403-3 tyrosine-protein kinase ZAP-70 isoform h3 (human), hZAP70/iso:h3

organism-modification


PR:000045788 tyrosine-protein kinase ZAP-70 phosphorylated 1 (human), hZAP70/Phos:1

organism-modification


PR:000049722 tyrosine-protein kinase ZAP-70 phosphorylated 2 (human), hZAP70/Phos:2

organism-modification


PR:000049723 tyrosine-protein kinase ZAP-70 phosphorylated 3 (human), hZAP70/Phos:3

organism-gene


PR:P43404 tyrosine-protein kinase ZAP-70 (mouse), mZAP70

organism-sequence


PR:P43404-1 tyrosine-protein kinase ZAP-70 isoform 1 (mouse), mZAP70/iso:1

organism-sequence


PR:P43404-2 tyrosine-protein kinase ZAP-70 isoform 2 (mouse), mZAP70/iso:2

organism-sequence


PR:P43404-3 tyrosine-protein kinase ZAP-70 isoform m3 (mouse), mZAP70/iso:m3

sequence


PR:000003066 tyrosine-protein kinase ZAP-70 isoform 1, ZAP70/iso:1

organism-sequence


PR:P43403-1 tyrosine-protein kinase ZAP-70 isoform 1 (human), hZAP70/iso:1

organism-modification


PR:000036629 tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 (human), hZAP70/iso:1/Phos:1
Yes
organism-sequence


PR:P43404-1 tyrosine-protein kinase ZAP-70 isoform 1 (mouse), mZAP70/iso:1

modification


PR:000003067 tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated form, ZAP70/iso:1/PhosRes+

modification


PR:000003068 tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1, ZAP70/iso:1/Phos:1

organism-modification


PR:000036629 tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 (human), hZAP70/iso:1/Phos:1
Yes
sequence


PR:000039469 tyrosine-protein kinase ZAP-70 isoform 2, ZAP70/iso:2

organism-sequence


PR:P43403-2 tyrosine-protein kinase ZAP-70 isoform 2 (human), hZAP70/iso:2

organism-sequence


PR:P43404-2 tyrosine-protein kinase ZAP-70 isoform 2 (mouse), mZAP70/iso:2

gene


PR:000003065 tyrosine-protein kinase SYK, SYK

organism-gene


PR:F1N9Y5 tyrosine-protein kinase SYK (chicken), chick-SYK

organism-gene


PR:P43405 tyrosine-protein kinase SYK (human), hSYK

organism-sequence


PR:P43405-1 tyrosine-protein kinase SYK isoform Long (human), hSYK/iso:Long

organism-sequence


PR:P43405-2 tyrosine-protein kinase SYK isoform Short (human), hSYK/iso:Short

organism-modification


PR:000049392 tyrosine-protein kinase SYK phosphotyrosine form (human), hSYK/PhosTyr+

organism-modification


PR:000026221 tyrosine-protein kinase SYK phosphorylated 2 (human), hSYK/Phos:2

organism-modification


PR:000049391 tyrosine-protein kinase SYK phosphorylated 3 (human), hSYK/Phos:3

organism-modification


PR:000070011 tyrosine-protein kinase SYK cysteinylated 1 (human), hSYK/Cyst:1

organism-modification


PR:000071958 tyrosine-protein kinase SYK deaminated 1 (human), hSYK/Deam:1

organism-gene


PR:P48025 tyrosine-protein kinase SYK (mouse), mSYK

organism-sequence


PR:P48025-1 tyrosine-protein kinase SYK isoform 1 (mouse), mSYK/iso:1

organism-modification


PR:000025834 tyrosine-protein kinase SYK isoform 1 phosphorylated 1 (mouse), mSYK/iso:1/Phos:1
Yes
organism-modification


PR:000049791 tyrosine-protein kinase SYK isoform 1 phosphorylated 2 (mouse), mSYK/iso:1/Phos:2

organism-modification


PR:000049792 tyrosine-protein kinase SYK isoform 1 unphosphorylated 2 (mouse), mSYK/iso:1/UnPhos:2

organism-modification


PR:000049793 tyrosine-protein kinase SYK isoform 1 phosphorylated 3 (mouse), mSYK/iso:1/Phos:3

organism-modification


PR:000049794 tyrosine-protein kinase SYK isoform 1 unphosphorylated 3 (mouse), mSYK/iso:1/UnPhos:3

organism-modification


PR:000049795 tyrosine-protein kinase SYK isoform 1 phosphorylated 4 (mouse), mSYK/iso:1/Phos:4

organism-modification


PR:000049796 tyrosine-protein kinase SYK isoform 1 phosphorylated 5 (mouse), mSYK/iso:1/Phos:5

organism-modification


PR:000049800 tyrosine-protein kinase SYK isoform 1 phosphorylated 6 (mouse), mSYK/iso:1/Phos:6

organism-gene


PR:Q64725 tyrosine-protein kinase SYK (rat), rSYK

organism-sequence


PR:Q64725-1 tyrosine-protein kinase SYK isoform SykB (rat), rSYK/iso:SykB

organism-sequence


PR:Q64725-2 tyrosine-protein kinase SYK isoform SykA (rat), rSYK/iso:SykA

sequence


PR:000025832 tyrosine-protein kinase SYK isoform 1, SYK/iso:1

organism-sequence


PR:P43405-1 tyrosine-protein kinase SYK isoform Long (human), hSYK/iso:Long

organism-sequence


PR:P48025-1 tyrosine-protein kinase SYK isoform 1 (mouse), mSYK/iso:1

organism-modification


PR:000025834 tyrosine-protein kinase SYK isoform 1 phosphorylated 1 (mouse), mSYK/iso:1/Phos:1
Yes
organism-modification


PR:000049791 tyrosine-protein kinase SYK isoform 1 phosphorylated 2 (mouse), mSYK/iso:1/Phos:2

organism-modification


PR:000049792 tyrosine-protein kinase SYK isoform 1 unphosphorylated 2 (mouse), mSYK/iso:1/UnPhos:2

organism-modification


PR:000049793 tyrosine-protein kinase SYK isoform 1 phosphorylated 3 (mouse), mSYK/iso:1/Phos:3

organism-modification


PR:000049794 tyrosine-protein kinase SYK isoform 1 unphosphorylated 3 (mouse), mSYK/iso:1/UnPhos:3

organism-modification


PR:000049795 tyrosine-protein kinase SYK isoform 1 phosphorylated 4 (mouse), mSYK/iso:1/Phos:4

organism-modification


PR:000049796 tyrosine-protein kinase SYK isoform 1 phosphorylated 5 (mouse), mSYK/iso:1/Phos:5

organism-modification


PR:000049800 tyrosine-protein kinase SYK isoform 1 phosphorylated 6 (mouse), mSYK/iso:1/Phos:6

modification


PR:000025833 tyrosine-protein kinase SYK isoform 1 phosphorylated 1, SYK/iso:1/Phos:1

organism-modification


PR:000025834 tyrosine-protein kinase SYK isoform 1 phosphorylated 1 (mouse), mSYK/iso:1/Phos:1
Yes
modification


PR:000026193 tyrosine-protein kinase SYK phosphorylated 2, SYK/Phos:2

organism-modification


PR:000026221 tyrosine-protein kinase SYK phosphorylated 2 (human), hSYK/Phos:2

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025834 mSYK/iso:1/Phos:1
UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048
"A tyrosine-protein kinase SYK isoform 1 phosphorylated 1 in mouse. UniProtKB:P48025-1, Tyr-317/Tyr-342/Tyr-346, MOD:00048." [PMID:15536084, PRO:JAN]		 acts_upstream_of_or_withinGO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis PMID:15536084
enablesGO:0019901 protein kinase binding with PR:P09769 FGR PMID:15536084
GO:0031625 ubiquitin protein ligase binding PMID:15536084
GO:0043548 phosphatidylinositol 3-kinase binding PMID:15536084
PR:000036629 hZAP70/iso:1/Phos:1

"A tyrosine-protein kinase ZAP-70 isoform 1 phosphorylated 1 in human." [PMID:9269777, PRO:CL]		 acts_upstream_of_or_withinGO:0090630 activation of GTPase activity PMID:9269777