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Protein Ontology report - protein pellino
PR:000003140 - http://purl.obolibrary.org/obo/PR_000003140
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003140   
  PRO nameprotein pellino 
  Definition"A protein that is the stand-alone version of the Pellino (Pfam:PF04710) domain. Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase." [Pfam:PF04710] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 6                                        
         Sequence3                                                  Organism-Sequence 10                                        
         Modification3                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038886
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000003140 protein pellino, TRAF6/iso:1/K63polyUbiq:1

gene


PR:000003141 E3 ubiquitin-protein ligase pellino homolog 1, PELI1

organism-gene


PR:Q8C669 E3 ubiquitin-protein ligase pellino homolog 1 (mouse), mPELI1

Yes
organism-sequence


PR:Q8C669-1 E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 (mouse), mPELI1/iso:1

organism-gene


PR:Q96FA3 E3 ubiquitin-protein ligase pellino homolog 1 (human), hPELI1

organism-sequence


PR:Q96FA3-1 E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 (human), hPELI1/iso:1

organism-modification


PR:000027047 E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 phosphorylated 1 (human), hPELI1/iso:1/Phos:1

organism-modification


PR:000063871 E3 ubiquitin-protein ligase pellino homolog 1 phosphorylated form (human), hPELI1/PhosRes+

organism-modification


PR:000064634 E3 ubiquitin-protein ligase pellino homolog 1 phosphorylated 1 (human), hPELI1/Phos:1

organism-modification


PR:000075404 E3 ubiquitin-protein ligase pellino homolog 1 methylated 1 (human), hPELI1/Me:1

organism-modification


PR:000075594 E3 ubiquitin-protein ligase pellino homolog 1 methylated 2 (human), hPELI1/Me:2

sequence


PR:000003142 E3 ubiquitin-protein ligase pellino homolog 1 isoform 1, PELI1/iso:1

organism-sequence


PR:Q8C669-1 E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 (mouse), mPELI1/iso:1

organism-sequence


PR:Q96FA3-1 E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 (human), hPELI1/iso:1

organism-modification


PR:000027047 E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 phosphorylated 1 (human), hPELI1/iso:1/Phos:1

modification


PR:000003144 E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 phosphorylated form, PELI1/iso:1/PhosRes+

modification


PR:000003145 E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 phosphorylated 1, PELI1/iso:1/Phos:1

organism-modification


PR:000027047 E3 ubiquitin-protein ligase pellino homolog 1 isoform 1 phosphorylated 1 (human), hPELI1/iso:1/Phos:1

gene


PR:000012539 E3 ubiquitin-protein ligase pellino homolog 2, PELI2

organism-gene


PR:Q8BST6 E3 ubiquitin-protein ligase pellino homolog 2 (mouse), mPELI2

organism-sequence


PR:Q8BST6-1 E3 ubiquitin-protein ligase pellino homolog 2 isoform m1 (mouse), mPELI2/iso:m1

organism-sequence


PR:Q8BST6-2 E3 ubiquitin-protein ligase pellino homolog 2 isoform m2 (mouse), mPELI2/iso:m2

organism-sequence


PR:Q8BST6-3 E3 ubiquitin-protein ligase pellino homolog 2 isoform m3 (mouse), mPELI2/iso:m3

organism-gene


PR:Q9HAT8 E3 ubiquitin-protein ligase pellino homolog 2 (human), hPELI2

organism-modification


PR:000048741 E3 ubiquitin-protein ligase pellino homolog 2 phosphorylated form (human), hPELI2/PhosRes+

organism-modification


PR:000027058 E3 ubiquitin-protein ligase pellino homolog 2 phosphorylated 1 (human), hPELI2/Phos:1
Yes
modification


PR:000027055 E3 ubiquitin-protein ligase pellino homolog 2 phosphorylated 1, PELI2/Phos:1

organism-modification


PR:000027058 E3 ubiquitin-protein ligase pellino homolog 2 phosphorylated 1 (human), hPELI2/Phos:1
Yes
gene


PR:000012540 E3 ubiquitin-protein ligase pellino homolog 3, PELI3

organism-gene


PR:Q8BXR6 E3 ubiquitin-protein ligase pellino homolog 3 (mouse), mPELI3

organism-sequence


PR:Q8BXR6-1 E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 (mouse), mPELI3/iso:2

organism-gene


PR:Q8N2H9 E3 ubiquitin-protein ligase pellino homolog 3 (human), hPELI3

organism-sequence


PR:Q8N2H9-1 E3 ubiquitin-protein ligase pellino homolog 3 isoform 1 (human), hPELI3/iso:1

organism-sequence


PR:Q8N2H9-2 E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 (human), hPELI3/iso:2
Yes
organism-sequence


PR:Q8N2H9-3 E3 ubiquitin-protein ligase pellino homolog 3 isoform h3 (human), hPELI3/iso:h3

organism-sequence


PR:Q8N2H9-4 E3 ubiquitin-protein ligase pellino homolog 3 isoform h4 (human), hPELI3/iso:h4

organism-modification


PR:000048742 E3 ubiquitin-protein ligase pellino homolog 3 phosphorylated form (human), hPELI3/PhosRes+

sequence


PR:000027048 E3 ubiquitin-protein ligase pellino homolog 3 isoform 1, PELI3/iso:1

organism-sequence


PR:Q8N2H9-1 E3 ubiquitin-protein ligase pellino homolog 3 isoform 1 (human), hPELI3/iso:1

sequence


PR:000027050 E3 ubiquitin-protein ligase pellino homolog 3 isoform 2, PELI3/iso:2

organism-sequence


PR:Q8BXR6-1 E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 (mouse), mPELI3/iso:2

organism-sequence


PR:Q8N2H9-2 E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 (human), hPELI3/iso:2
Yes
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TRAF6/iso:1/K63polyUbiq:1 forms found in complexes   

TRAF6/iso:1/K63polyUbiq:1 Component
 Complexes
PR:Q8C669 mPELI1 PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027058 hPELI2/Phos:1
UniProtKB:Q9HAT8, Thr-290, MOD:00047
"An E3 ubiquitin-protein ligase pellino homolog 2 phosphorylated 1 in human. This is the active form and it is phosphorylated at least in a critical Thr residue. UniProtKB:Q9HAT8, Thr-290, MOD:00047." [PMID:19264966, PRO:CNA]		 located_inGO:0005829 cytosol Reactome:REACT_22715
PR:Q8N2H9-2 hPELI3/iso:2
pellino 3 beta (human) | pellino 3b (human) | pellino-3 beta (human)
"An E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 that is encoded in the genome of human." [PMID:12874243, PRO:CNA]		 acts_upstream_of_or_withinGO:0070534 protein K63-linked ubiquitination PMID:18326498
GO:2000660 negative regulation of interleukin-1-mediated signaling pathway PMID:18326498