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Protein Ontology report - RAF proto-oncogene serine/threonine-protein kinase
PR:000003244 - http://purl.obolibrary.org/obo/PR_000003244
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003244   
  PRO nameRAF proto-oncogene serine/threonine-protein kinase 
  Synonyms
PRO-Short-label: EXACT:RAF1
Gene-based: RELATED:RAF
Other: EXACT:cRaf | proto-oncogene c-RAF | Raf-1
  Definition"A protein that is a translation product of the human RAF1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 7                                        
         Sequence2                                                  Organism-Sequence 6                                        
         Modification4                                                  Organism-Modification 59                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2184
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000003244 RAF proto-oncogene serine/threonine-protein kinase, RAF1

organism-gene


PR:O94235 serine/threonine-protein kinase mph1 (Schizosaccharomyces pombe 972h-), Spom972h-RAF1

organism-gene


PR:P04049 RAF proto-oncogene serine/threonine-protein kinase (human), hRAF1
Yes
organism-sequence


PR:P04049-1 RAF proto-oncogene serine/threonine-protein kinase isoform 1 (human), hRAF1/iso:1

organism-modification


PR:000026210 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3 (human), hRAF1/iso:1/Phos:3

organism-modification


PR:000036643 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2 (human), hRAF1/iso:1/Phos:2
Yes
organism-sequence


PR:P04049-2 RAF proto-oncogene serine/threonine-protein kinase isoform 2 (human), hRAF1/iso:2

organism-modification


PR:000045631 RAF proto-oncogene serine/threonine-protein kinase phosphorylated 1 (human), hRAF1/Phos:1

organism-modification


PR:000048997 RAF proto-oncogene serine/threonine-protein kinase phosphorylated 3 (human), hRAF1/Phos:3

organism-modification


PR:000048998 RAF proto-oncogene serine/threonine-protein kinase phosphorylated 4 (human), hRAF1/Phos:4

organism-modification


PR:000048999 RAF proto-oncogene serine/threonine-protein kinase phosphorylated 5 (human), hRAF1/Phos:5

organism-modification


PR:000049000 RAF proto-oncogene serine/threonine-protein kinase phosphorylated 6 (human), hRAF1/Phos:6

organism-modification


PR:000049001 RAF proto-oncogene serine/threonine-protein kinase phosphorylated 7 (human), hRAF1/Phos:7

organism-modification


PR:000049002 RAF proto-oncogene serine/threonine-protein kinase phosphorylated 8 (human), hRAF1/Phos:8

organism-modification


PR:000049003 RAF proto-oncogene serine/threonine-protein kinase phosphorylated 9 (human), hRAF1/Phos:9

organism-modification


PR:000060294 RAF proto-oncogene serine/threonine-protein kinase sequence variant V263A phosphorylated 1 (human), hRAF1/var:V263A/Phos:1

organism-modification


PR:000060304 RAF proto-oncogene serine/threonine-protein kinase sequence variant N262L phosphorylated 1 (human), hRAF1/var:N262L/Phos:1

organism-modification


PR:000060342 RAF proto-oncogene serine/threonine-protein kinase sequence variant L613V phosphorylated 1 (human), hRAF1/var:L613V/Phos:1

organism-modification


PR:000060487 RAF proto-oncogene serine/threonine-protein kinase sequence variant S259T phosphorylated 1 (human), hRAF1/var:S259T/Phos:1

organism-modification


PR:000060534 RAF proto-oncogene serine/threonine-protein kinase sequence variant P261A phosphorylated 1 (human), hRAF1/var:P261A/Phos:1

organism-modification


PR:000060574 RAF proto-oncogene serine/threonine-protein kinase sequence variant G370R phosphorylated 1 (human), hRAF1/var:G370R/Phos:1

organism-modification


PR:000060735 RAF proto-oncogene serine/threonine-protein kinase sequence variant R256S phosphorylated 1 (human), hRAF1/var:R256S/Phos:1

organism-modification


PR:000060783 RAF proto-oncogene serine/threonine-protein kinase sequence variant S427G phosphorylated 1 (human), hRAF1/var:S427G/Phos:1

organism-modification


PR:000060875 RAF proto-oncogene serine/threonine-protein kinase sequence variant S427G phosphorylated 2 (human), hRAF1/var:S427G/Phos:2

organism-modification


PR:000060889 RAF proto-oncogene serine/threonine-protein kinase sequence variant P261N phosphorylated 1 (human), hRAF1/var:P261N/Phos:1

organism-modification


PR:000061147 RAF proto-oncogene serine/threonine-protein kinase sequence variant T260I phosphorylated 1 (human), hRAF1/var:T260I/Phos:1

organism-modification


PR:000061178 RAF proto-oncogene serine/threonine-protein kinase sequence variant S259P phosphorylated 1 (human), hRAF1/var:S259P/Phos:1

organism-modification


PR:000061258 RAF proto-oncogene serine/threonine-protein kinase sequence variant P261L phosphorylated 1 (human), hRAF1/var:P261L/Phos:1

organism-modification


PR:000061438 RAF proto-oncogene serine/threonine-protein kinase sequence variant P261T phosphorylated 1 (human), hRAF1/var:P261T/Phos:1

organism-modification


PR:000061913 RAF proto-oncogene serine/threonine-protein kinase sequence variant S259P phosphorylated 2 (human), hRAF1/var:S259P/Phos:2

organism-modification


PR:000061916 RAF proto-oncogene serine/threonine-protein kinase sequence variant P261A phosphorylated 2 (human), hRAF1/var:P261A/Phos:2

organism-modification


PR:000062212 RAF proto-oncogene serine/threonine-protein kinase sequence variant P261L phosphorylated 2 (human), hRAF1/var:P261L/Phos:2

organism-modification


PR:000062247 RAF proto-oncogene serine/threonine-protein kinase sequence variant D486N phosphorylated 1 (human), hRAF1/var:D486N/Phos:1

organism-modification


PR:000062287 RAF proto-oncogene serine/threonine-protein kinase sequence variant D486N phosphorylated 2 (human), hRAF1/var:D486N/Phos:2

organism-modification


PR:000062301 RAF proto-oncogene serine/threonine-protein kinase sequence variant G370R phosphorylated 2 (human), hRAF1/var:G370R/Phos:2

organism-modification


PR:000062538 RAF proto-oncogene serine/threonine-protein kinase sequence variant P261S phosphorylated 1 (human), hRAF1/var:P261S/Phos:1

organism-modification


PR:000062644 RAF proto-oncogene serine/threonine-protein kinase sequence variant D486G phosphorylated 1 (human), hRAF1/var:D486G/Phos:1

organism-modification


PR:000062694 RAF proto-oncogene serine/threonine-protein kinase sequence variant L613V phosphorylated 2 (human), hRAF1/var:L613V/Phos:2

organism-modification


PR:000062754 RAF proto-oncogene serine/threonine-protein kinase sequence variant S257L phosphorylated 1 (human), hRAF1/var:S257L/Phos:1

organism-modification


PR:000062783 RAF proto-oncogene serine/threonine-protein kinase sequence variant P261S phosphorylated 2 (human), hRAF1/var:P261S/Phos:2

organism-modification


PR:000062809 RAF proto-oncogene serine/threonine-protein kinase sequence variant T491R phosphorylated 1 (human), hRAF1/var:T491R/Phos:1

organism-modification


PR:000062928 RAF proto-oncogene serine/threonine-protein kinase sequence variant T260I phosphorylated 2 (human), hRAF1/var:T260I/Phos:2

organism-modification


PR:000063034 RAF proto-oncogene serine/threonine-protein kinase sequence variant V263A phosphorylated 2 (human), hRAF1/var:V263A/Phos:2

organism-modification


PR:000063172 RAF proto-oncogene serine/threonine-protein kinase sequence variant T491R phosphorylated 2 (human), hRAF1/var:T491R/Phos:2

organism-modification


PR:000063187 RAF proto-oncogene serine/threonine-protein kinase sequence variant S257L phosphorylated 2 (human), hRAF1/var:S257L/Phos:2

organism-modification


PR:000063405 RAF proto-oncogene serine/threonine-protein kinase sequence variant D486G phosphorylated 2 (human), hRAF1/var:D486G/Phos:2

organism-modification


PR:000063408 RAF proto-oncogene serine/threonine-protein kinase sequence variant G361A phosphorylated 1 (human), hRAF1/var:G361A/Phos:1

organism-modification


PR:000063432 RAF proto-oncogene serine/threonine-protein kinase sequence variant R256S phosphorylated 2 (human), hRAF1/var:R256S/Phos:2

organism-modification


PR:000063451 RAF proto-oncogene serine/threonine-protein kinase sequence variant T491I phosphorylated 1 (human), hRAF1/var:T491I/Phos:1

organism-modification


PR:000063537 RAF proto-oncogene serine/threonine-protein kinase sequence variant T260R phosphorylated 1 (human), hRAF1/var:T260R/Phos:1

organism-modification


PR:000063579 RAF proto-oncogene serine/threonine-protein kinase sequence variant P261T phosphorylated 2 (human), hRAF1/var:P261T/Phos:2

organism-modification


PR:000063663 RAF proto-oncogene serine/threonine-protein kinase sequence variant S259T phosphorylated 2 (human), hRAF1/var:S259T/Phos:2

organism-modification


PR:000063974 RAF proto-oncogene serine/threonine-protein kinase sequence variant T491I phosphorylated 2 (human), hRAF1/var:T491I/Phos:2

organism-modification


PR:000064065 RAF proto-oncogene serine/threonine-protein kinase sequence variant T260R phosphorylated 2 (human), hRAF1/var:T260R/Phos:2

organism-modification


PR:000064095 RAF proto-oncogene serine/threonine-protein kinase sequence variant P261N phosphorylated 2 (human), hRAF1/var:P261N/Phos:2

organism-modification


PR:000064135 RAF proto-oncogene serine/threonine-protein kinase phosphotyrosine form (human), hRAF1/PhosTyr+

organism-modification


PR:000064182 RAF proto-oncogene serine/threonine-protein kinase sequence variant S259F phosphorylated 1 (human), hRAF1/var:S259F/Phos:1

organism-modification


PR:000064238 RAF proto-oncogene serine/threonine-protein kinase sequence variant G361A phosphorylated 2 (human), hRAF1/var:G361A/Phos:2

organism-modification


PR:000064242 RAF proto-oncogene serine/threonine-protein kinase sequence variant N262L phosphorylated 2 (human), hRAF1/var:N262L/Phos:2

organism-modification


PR:000064564 RAF proto-oncogene serine/threonine-protein kinase sequence variant S259F phosphorylated 2 (human), hRAF1/var:S259F/Phos:2

organism-modification


PR:000065842 RAF proto-oncogene serine/threonine-protein kinase phosphorylated 2 (human), hRAF1/Phos:2

organism-modification


PR:000070181 RAF proto-oncogene serine/threonine-protein kinase deaminated 1 (human), hRAF1/Deam:1

organism-modification


PR:000078506 RAF proto-oncogene serine/threonine-protein kinase cysteinylated 1 (human), hRAF1/Cyst:1

organism-gene


PR:P05625 RAF proto-oncogene serine/threonine-protein kinase (chicken), chick-RAF1

organism-sequence


PR:P05625-1 RAF proto-oncogene serine/threonine-protein kinase isoform 1 (chicken), chick-RAF1/iso:1

organism-sequence


PR:P05625-2 RAF proto-oncogene serine/threonine-protein kinase isoform 2 (chicken), chick-RAF1/iso:2

organism-gene


PR:P06784 serine/threonine-protein kinase STE7 (yeast), ySTE7

organism-gene


PR:P11345 RAF proto-oncogene serine/threonine-protein kinase (rat), rRAF1

organism-gene


PR:Q54TH6 probable serine/threonine-protein kinase DDB_G0281745 (Dictyostelium discoideum), Dicty-RAF1

organism-gene


PR:Q99N57 RAF proto-oncogene serine/threonine-protein kinase (mouse), mRAF1

organism-sequence


PR:Q99N57-1 RAF proto-oncogene serine/threonine-protein kinase isoform 1 (mouse), mRAF1/iso:1

organism-sequence


PR:Q99N57-2 RAF proto-oncogene serine/threonine-protein kinase isoform 2 (mouse), mRAF1/iso:2

organism-modification


PR:000046209 RAF proto-oncogene serine/threonine-protein kinase phosphorylated 1 (mouse), mRAF1/Phos:1

sequence


PR:000003245 RAF proto-oncogene serine/threonine-protein kinase isoform 1, RAF1/iso:1

organism-sequence


PR:P04049-1 RAF proto-oncogene serine/threonine-protein kinase isoform 1 (human), hRAF1/iso:1

organism-modification


PR:000026210 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3 (human), hRAF1/iso:1/Phos:3

organism-modification


PR:000036643 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2 (human), hRAF1/iso:1/Phos:2
Yes
organism-sequence


PR:Q99N57-1 RAF proto-oncogene serine/threonine-protein kinase isoform 1 (mouse), mRAF1/iso:1

modification


PR:000003247 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated form, RAF1/iso:1/PhosRes+

modification


PR:000003249 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 1, RAF1/iso:1/Phos:1

modification


PR:000003250 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2, RAF1/iso:1/Phos:2

organism-modification


PR:000036643 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2 (human), hRAF1/iso:1/Phos:2
Yes
modification


PR:000026174 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3, RAF1/iso:1/Phos:3

organism-modification


PR:000026210 RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3 (human), hRAF1/iso:1/Phos:3

sequence


PR:000003248 RAF proto-oncogene serine/threonine-protein kinase isoform 2, RAF1/iso:2

organism-sequence


PR:P04049-2 RAF proto-oncogene serine/threonine-protein kinase isoform 2 (human), hRAF1/iso:2

organism-sequence


PR:Q99N57-2 RAF proto-oncogene serine/threonine-protein kinase isoform 2 (mouse), mRAF1/iso:2

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036643 hRAF1/iso:1/Phos:2
UniProtKB:P04049-1, Ser-338/Ser-339, MOD:00046
"A RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2 in human. UniProtKB:P04049-1, Ser-338/Ser-339, MOD:00046." [PMID:15849194, PRO:JAN]		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:15849194
enablesGO:0004674 protein serine/threonine kinase activity PMID:15849194
GO:0005515 protein binding PMID:15849194
located_inGO:0005741 mitochondrial outer membrane PMID:15849194
PR:P04049 hRAF1
RAF | RAF1 | cRaf (human) | proto-oncogene c-RAF (human) | Raf-1 (human)
"A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human." [PMID:20703093, PRO:KER]		 acts_upstream_of_or_withinGO:0032877 positive regulation of DNA endoreduplication PMID:20703093
enablesGO:0005515 protein binding with PR:O60566 BUB1B PMID:20703093