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Protein Ontology report - interferon regulatory factor 3 isoform 1 phosphorylated 1
PR:000003260 -
http://purl.obolibrary.org/obo/PR_000003260
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000003260
PRO name
interferon regulatory factor 3 isoform 1 phosphorylated 1
Synonyms
PRO-Short-label
:
EXACT:
IRF3/iso:1/Phos:1
Other
:
EXACT:
IRF3 active form | phospho IRF3
Definition
"An interferon regulatory factor 3 isoform 1 phosphorylated form in which the phosphorylation occurs upon stimulation by virus infection or treatment with double-stranded RNA or LPS. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit. Example:
UniProtKB:Q14653-1
, Ser-385/Ser-386,
MOD:00046
." [
PMID:14703513
,
PMID:20043992
, TLR:AMM]
Comment
Requested by=TLR.
PRO Category
modification
Parent
PR:000003259
interferon regulatory factor 3 isoform 1 phosphorylated form
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
2
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000003260
interferon regulatory factor 3 isoform 1 phosphorylated 1, IRF3/iso:1/Phos:1
organism-modification
PR:000025763
interferon regulatory factor 3 isoform 1 phosphorylated 1 (human), hIRF3/iso:1/Phos:1
Yes
Yes
organism-modification
PR:000027097
interferon regulatory factor 3 isoform 1 phosphorylated 1 (mouse), mIRF3/iso:1/Phos:1
Yes
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IRF3/iso:1/Phos:1
forms found in complexes
IRF3/iso:1/Phos:1
Component
Complexes
PR:000025763
hIRF3/iso:1/Phos:1
PR:000036002
IRF3-P:IRF3-P:KPNA4 complex (human)
PR:000027097
mIRF3/iso:1/Phos:1
PR:000027098
IRF3-P:IRF3-P complex (mouse)
PR:000036043
IRF3-P:p65 complex (mouse)
PR:000036047
IRF3-P:p65:ISRE complex (mouse)
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000025763
hIRF3/iso:1/Phos:1
UniProtKB:Q14653-1, Ser-385/Ser-386, MOD:00046 | IRF3-P (human)
"An interferon regulatory factor 3 isoform 1 phosphorylated 1 in human. UniProtKB:Q14653-1, Ser-385/Ser-386, MOD:00046." [PMID:10805757, PRO:CNA]
enables
GO:0005515
protein binding
with
PR:O14980
chromosome region maintenance 1 protein homolog (human)
PMID:10805757
located_in
GO:0005829
cytosol
Reactome:REACT_7149