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Protein Ontology report - suppressor of fused homolog
PR:000003324 - http://purl.obolibrary.org/obo/PR_000003324
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000003324   
  PRO namesuppressor of fused homolog 
  Synonyms
PRO-Short-label: EXACT:SUFU
Gene-based: RELATED:UNQ650/PRO1280
Other: EXACT:SUFUH
  Definition"A protein that is a translation product of the human SUFU gene or a 1:1 ortholog thereof." [MGI:1345643, PRO:HJD] 
  PRO Categorygene 
  ParentPR:000000001
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence3                                                  Organism-Sequence 7                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF011844
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000003324 suppressor of fused homolog, SUFU

organism-gene


PR:Q9UMX1 suppressor of fused homolog (human), hSUFU

organism-sequence


PR:Q9UMX1-1 suppressor of fused homolog isoform 1 (human), hSUFU/iso:1

organism-sequence


PR:Q9UMX1-2 suppressor of fused homolog isoform h2 (human), hSUFU/iso:h2

organism-sequence


PR:Q9UMX1-3 suppressor of fused homolog isoform h3 (human), hSUFU/iso:h3

organism-gene


PR:Q9Z0P7 suppressor of fused homolog (mouse), mSUFU
Yes
organism-sequence


PR:Q9Z0P7-1 suppressor of fused homolog isoform 1 (mouse), mSUFU/iso:1
Yes
organism-sequence


PR:Q9Z0P7-2 suppressor of fused homolog isoform m2 (mouse), mSUFU/iso:m2

organism-sequence


PR:Q9Z0P7-3 suppressor of fused homolog isoform 3 (mouse), mSUFU/iso:3

organism-sequence


PR:Q9Z0P7-4 suppressor of fused homolog isoform 4 (mouse), mSUFU/iso:4
Yes
sequence


PR:000003325 suppressor of fused homolog isoform 1, SUFU/iso:1

organism-sequence


PR:Q9UMX1-1 suppressor of fused homolog isoform 1 (human), hSUFU/iso:1

organism-sequence


PR:Q9Z0P7-1 suppressor of fused homolog isoform 1 (mouse), mSUFU/iso:1
Yes
sequence


PR:000003326 suppressor of fused homolog isoform 3, SUFU/iso:3

organism-sequence


PR:Q9Z0P7-3 suppressor of fused homolog isoform 3 (mouse), mSUFU/iso:3

sequence


PR:000003327 suppressor of fused homolog isoform 4, SUFU/iso:4

organism-sequence


PR:Q9Z0P7-4 suppressor of fused homolog isoform 4 (mouse), mSUFU/iso:4
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q9Z0P7
mSUFU
Sufu		 acts_upstream_of_or_withinGO:0021513 spinal cord dorsal/ventral patterning PMID:16459298
GO:0043588 skin development PMID:16459298
GO:0045879 negative regulation of smoothened signaling pathway PMID:16459298
PR:Q9Z0P7-1
mSUFU/iso:1
 enablesGO:0005515 protein binding with PR:P47806 Gli MGI:1861566; PMID:10920228
GO:0005515 protein binding with PR:Q61602 Gli3 MGI:1861566; PMID:10920228
located_inGO:0005634 nucleus MGI:3692156; PMID:16254602
GO:0005737 cytoplasm MGI:3608582; PMID:16316410
GO:0005929 cilium MGI:3692156; PMID:16254602
PR:Q9Z0P7-4
mSUFU/iso:4
suppressor of fused homolog isoform SU(FU)-XL (mouse)		 acts_upstream_of_or_withinGO:0000122 negative regulation of transcription by RNA polymerase II MGI:1346364; PMID:10531011
GO:0045879 negative regulation of smoothened signaling pathway MGI:1346364; PMID:10531011
enablesGO:0005515 protein binding with PR:P10071 GLI3 MGI:1346364; PMID:10531011
GO:0005515 protein binding with PR:P47806 Gli MGI:1346364; PMID:10531011
GO:0005515 protein binding with PR:Q0VGT2 Gli2 MGI:1346364; PMID:10531011
located_inGO:0005737 cytoplasm MGI:1346364; PMID:10531011