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Protein Ontology report - E3 SUMO-protein ligase PIAS2

PR:000003436 - http://purl.obolibrary.org/obo/PR_000003436

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000003436

PRO name

E3 SUMO-protein ligase PIAS2

Synonyms

PRO-Short-label:	EXACT:	PIAS2
Gene-based:	RELATED:	PIASX
Other:	EXACT:	androgen receptor-interacting protein 3 \| ARIP3 \| miz1 \| Msx-interacting zinc finger protein \| PIAS-NY protein \| protein inhibitor of activated STAT x \| protein inhibitor of activated STAT2
	RELATED:	DAB2-interacting protein \| DIP

Definition

"An E3 SUMO-protein ligase PIAS that is a translation product of the human PIAS2 gene or a 1:1 ortholog thereof." [MGI:1096566, PRO:HJD]

PRO Category

gene

Parent

PR:000003444 E3 SUMO-protein ligase PIAS

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	3
Sequence	2	Organism-Sequence	8
Modification	0	Organism-Modification	1

Term Hierarchy
Visualization

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000003436 E3 SUMO-protein ligase PIAS2

PIAS2

organism-gene

PR:O75928 E3 SUMO-protein ligase PIAS2 (human)

hPIAS2

organism-sequence

PR:O75928-1 E3 SUMO-protein ligase PIAS2 isoform hPIAS2-beta (human)

hPIAS2/iso:hPIAS2-beta

organism-sequence

PR:O75928-2 E3 SUMO-protein ligase PIAS2 isoform hPIAS2-alpha (human)

hPIAS2/iso:hPIAS2-alpha

organism-sequence

PR:O75928-3 E3 SUMO-protein ligase PIAS2 isoform h3 (human)

hPIAS2/iso:h3

organism-modification

PR:000076505 E3 SUMO-protein ligase PIAS2 cysteinylated 1 (human)

hPIAS2/Cyst:1

organism-gene

PR:Q6AZ28 E3 SUMO-protein ligase PIAS2 (rat)

rPIAS2

organism-gene

PR:Q8C5D8 E3 SUMO-protein ligase PIAS2 (mouse)

mPIAS2

organism-sequence

PR:Q8C5D8-1 E3 SUMO-protein ligase PIAS2 isoform 1 (mouse)

mPIAS2/iso:1

Yes

organism-sequence

PR:Q8C5D8-2 E3 SUMO-protein ligase PIAS2 isoform 2 (mouse)

mPIAS2/iso:2

Yes

organism-sequence

PR:Q8C5D8-3 E3 SUMO-protein ligase PIAS2 isoform 3 (mouse)

mPIAS2/iso:3

organism-sequence

PR:Q8C5D8-4 E3 SUMO-protein ligase PIAS2 isoform 4 (mouse)

mPIAS2/iso:4

organism-sequence

PR:Q8C5D8-5 E3 SUMO-protein ligase PIAS2 isoform 5 (mouse)

mPIAS2/iso:5

sequence

PR:000003437 E3 SUMO-protein ligase PIAS2 isoform 1

PIAS2/iso:1

organism-sequence

PR:Q8C5D8-1 E3 SUMO-protein ligase PIAS2 isoform 1 (mouse)

mPIAS2/iso:1

Yes

sequence

PR:000003442 E3 SUMO-protein ligase PIAS2 isoform 2

PIAS2/iso:2

organism-sequence

PR:Q8C5D8-2 E3 SUMO-protein ligase PIAS2 isoform 2 (mouse)

mPIAS2/iso:2

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:Q8C5D8-1 mPIAS2/iso:1 E3 SUMO-protein ligase PIAS2 isoform Miz1 (mouse) \| E3 SUMO-protein ligase PIAS2 isoform PIASx-beta (mouse) "An E3 SUMO-protein ligase PIAS2 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]	acts_upstream_of_or_within	GO:0006351 DNA-templated transcription	MGI:894957; PMID:9256341
		GO:0006357 regulation of transcription by RNA polymerase II	MGI:894957; PMID:9256341
		GO:0016925 protein sumoylation	PMID:15767674
		GO:0045667 regulation of osteoblast differentiation	MGI:3723333; PMID:17623776
		GO:0045893 positive regulation of DNA-templated transcription	MGI:3723333; PMID:17623776
	enables	GO:0003677 DNA binding	MGI:894957; PMID:9256341
		GO:0005515 protein binding with PR:P29037 mTBP	PMID:16522640
		GO:0005515 protein binding	PMID:16522640
		GO:0019789 SUMO transferase activity	PMID:15767674
	located_in	GO:0005634 nucleus	PMID:16522640
	located_in	GO:0016604 nuclear body	MGI:3629292; PMID:16675951
PR:Q8C5D8-2 mPIAS2/iso:2 E3 SUMO-protein ligase PIAS2 isoform ARIP3 (mouse) \| E3 SUMO-protein ligase PIAS2 isoform PIASx-alpha (mouse) "An E3 SUMO-protein ligase PIAS2 isoform 2 that is encoded in the genome of mouse." [PRO:HJD]	acts_upstream_of_or_within	GO:0045944 positive regulation of transcription by RNA polymerase II	MGI:1929027; PMID:11104669
	enables	GO:0005515 protein binding with PR:P98078-3	MGI:1929027; PMID:11104669