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Protein Ontology report - mitotic checkpoint serine/threonine-protein kinase BUB1
PR:000004854 - http://purl.obolibrary.org/obo/PR_000004854
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000004854   
  PRO namemitotic checkpoint serine/threonine-protein kinase BUB1 
  Synonyms
PRO-Short-label: EXACT:BUB1
Gene-based: RELATED:BUB1L
Other: EXACT:BUB1A
  Definition"A BUB1/BUB1B protein that is a translation product of the human BUB1 gene or a 1:1 ortholog thereof." [PMID:22698286, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000035665
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 6                                        
         Sequence0                                                  Organism-Sequence 6                                        
         Modification9                                                  Organism-Modification 29                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1949
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000004854 mitotic checkpoint serine/threonine-protein kinase BUB1, BUB1

organism-gene


PR:O08901 mitotic checkpoint serine/threonine-protein kinase BUB1 (mouse), mBUB1
Yes
organism-modification


PR:000035408 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (mouse), mBUB1/Phos:4

organism-modification


PR:000035416 mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (mouse), mBUB1/PhosRes-

organism-gene


PR:O22806 mitotic spindle checkpoint protein BUBR1 (Arabidopsis thaliana), At-BUBR1

organism-sequence


PR:O22806-1 mitotic spindle checkpoint protein BUBR1 isoform 1 (Arabidopsis thaliana), At-BUBR1/iso:1

organism-sequence


PR:O22806-2 mitotic spindle checkpoint protein BUBR1 isoform 2 (Arabidopsis thaliana), At-BUBR1/iso:2

organism-gene


PR:O43683 mitotic checkpoint serine/threonine-protein kinase BUB1 (human), hBUB1
Yes
Yes
organism-sequence


PR:O43683-1 mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h1 (human), hBUB1/iso:h1

organism-sequence


PR:O43683-2 mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h2 (human), hBUB1/iso:h2

organism-sequence


PR:O43683-3 mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h3 (human), hBUB1/iso:h3

organism-modification


PR:000035399 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (human), hBUB1/Phos:2

organism-modification


PR:000035405 mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (human), hBUB1/PhosRes-
Yes
organism-modification


PR:000035407 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (human), hBUB1/Phos:4
Yes
organism-modification


PR:000035412 mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 7 (human), hBUB1/Phos:7
Yes
Yes
organism-modification


PR:000035418 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 (human), hBUB1/Phos:8

organism-modification


PR:000035421 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 (human), hBUB1/Phos:10
Yes
organism-modification


PR:000065566 mitotic checkpoint serine/threonine-protein kinase BUB1 cysteinylated 1 (human), hBUB1/Cyst:1

organism-modification


PR:000066031 mitotic checkpoint serine/threonine-protein kinase BUB1 cysteinylated 2 (human), hBUB1/Cyst:2

organism-modification


PR:000071538 mitotic checkpoint serine/threonine-protein kinase BUB1 methylated 1 (human), hBUB1/Me:1

organism-modification


PR:000072604 mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 1 (human), hBUB1/Deam:1

organism-modification


PR:000073548 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 (human), hBUB1/Phos:1

organism-modification


PR:000073549 mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 2 (human), hBUB1/Deam:2

organism-modification


PR:000076189 mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 3 (human), hBUB1/Deam:3

organism-modification


PR:000076708 mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 4 (human), hBUB1/Deam:4

organism-modification


PR:000076926 mitotic checkpoint serine/threonine-protein kinase BUB1 deaminated 5 (human), hBUB1/Deam:5

organism-modification


PR:000078756 mitotic checkpoint serine/threonine-protein kinase BUB1 methylated 2 (human), hBUB1/Me:2

organism-modification


PR:000079803 mitotic checkpoint serine/threonine-protein kinase BUB1 methylated 3 (human), hBUB1/Me:3

organism-gene


PR:Q21776 mitotic checkpoint serine/threonine-protein kinase bub-1 (worm), BUB1 (worm)

organism-gene


PR:Q54CV5 probable inactive serine/threonine-protein kinase bub1 (Dictyostelium discoideum), Dicty-BUB1

organism-gene


PR:Q6GPC9 mitotic checkpoint serine/threonine-protein kinase BUB1 (frog), frog-bub1

organism-sequence


PR:Q98UH3 mitotic checkpoint serine/threonine-protein kinase BUB1 sequence variant 1 (frog), frog-BUB1/var:1
Yes
organism-modification


PR:000029911 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 (frog), frog-BUB1/Phos:1
Yes
organism-modification


PR:000029913 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (frog), frog-BUB1/Phos:2

organism-modification


PR:000029917 mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (frog), frog-BUB1/PhosRes-

organism-modification


PR:000035404 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog), frog-BUB1/Phos:3
Yes
modification


PR:000029910 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1, BUB1/Phos:1

organism-modification


PR:000029911 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 (frog), frog-BUB1/Phos:1
Yes
modification


PR:000029912 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2, BUB1/Phos:2

organism-modification


PR:000029913 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (frog), frog-BUB1/Phos:2

organism-modification


PR:000035399 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (human), hBUB1/Phos:2

organism-modification


PR:000035401 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (yeast), yBUB1/Phos:2

modification


PR:000029916 mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form, BUB1/PhosRes-

organism-modification


PR:000029917 mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (frog), frog-BUB1/PhosRes-

organism-modification


PR:000035405 mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (human), hBUB1/PhosRes-
Yes
organism-modification


PR:000035414 mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (Schizosaccharomyces pombe 972h-), Spom972h-BUB1/PhosRes-

organism-modification


PR:000035415 mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (yeast), yBUB1/PhosRes-

organism-modification


PR:000035416 mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (mouse), mBUB1/PhosRes-

modification


PR:000035403 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3, BUB1/Phos:3

organism-modification


PR:000035404 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog), frog-BUB1/Phos:3
Yes
modification


PR:000035406 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4, BUB1/Phos:4

organism-modification


PR:000035407 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (human), hBUB1/Phos:4
Yes
organism-modification


PR:000035408 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (mouse), mBUB1/Phos:4

modification


PR:000035413 BUB1 CDK-consensus sites phosphorylated form, BUB1/PhosRes+

organism-modification


PR:000035411 mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 6 (Schizosaccharomyces pombe 972h-), Spom972h-BUB1/Phos:6
Yes
organism-modification


PR:000035412 mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 7 (human), hBUB1/Phos:7
Yes
Yes
organism-modification


PR:000035419 mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 1 (yeast), yBUB1/Phos:CDK-1
Yes
modification


PR:000035417 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8, BUB1/Phos:8

organism-modification


PR:000035418 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 (human), hBUB1/Phos:8

modification


PR:000035420 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10, BUB1/Phos:10

organism-modification


PR:000035421 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 (human), hBUB1/Phos:10
Yes
modification


PR:000035691 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5, BUB1/Phos:5

organism-modification


PR:000035410 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5 (Schizosaccharomyces pombe 972h-), Spom972h-BUB1/Phos:5
Yes
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BUB1 forms found in complexes   

BUB1 Component
 Complexes
PR:000035412 hBUB1/Phos:7 PR:000035581
PR:O43683 hBUB1 PR:000035564^P000035567^P000035576^P000035577^P000035579
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000029911
frog-BUB1/Phos:1
xBUB1 phosphorylated		 enablesincreased GO:0016301 kinase activity relative to PR:000029917 frog-BUB1/PhosRes- PMID:11231148
PR:000035404
frog-BUB1/Phos:3
UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046 | xBUB1 hyperphosphorylated		 acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:15241477
GO:0034501 protein localization to kinetochore PMID:15241477
GO:0034501 protein localization to kinetochore PMID:15241477
GO:0034501 protein localization to kinetochore PMID:15241477
enablesincreased GO:0004672 protein kinase activity relative to PR:000029917 frog-BUB1/PhosRes- PMID:15241477
PR:000035405
hBUB1/PhosRes-
 enablesNOT GO:0005515 protein binding with PR:P53350 hPLK1 PMID:16760428
located_inGO:0000776 kinetochore PMID:16760428
PR:000035407
hBUB1/Phos:4
hBUB1 phosphorylated		 enablesincreased GO:0004672 protein kinase activity relative to PR:000035405 hBUB1/PhosRes- PMID:15525512
PR:000035410
Spom972h-BUB1/Phos:5
 acts_upstream_of_or_withinGO:0007094 mitotic spindle assembly checkpoint signaling PMID:12606573
GO:0045143 homologous chromosome segregation PMID:12606573
PR:000035411
Spom972h-BUB1/Phos:6
UniProtKB:O94751, (Thr-340, MOD:00047 and/or Thr-423, MOD:00047 and/or Thr-455, MOD:00047 and/or Ser-466, MOD:00046)		 acts_upstream_of_or_withinGO:0007094 mitotic spindle assembly checkpoint signaling PMID:12606573
GO:0045143 homologous chromosome segregation PMID:12606573
located_inGO:0000776 kinetochore PMID:12606573
PR:000035412
hBUB1/Phos:7
UniProtKB:O43683, Ser-593, MOD:00046|Thr-609, MOD:00047 | UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047		 acts_upstream_of_or_withinGO:0034501 protein localization to kinetochore PMID:16760428
enablesincreased GO:0005515 protein binding with PR:Q9NQS7 hINCENP PMID:16760428
PR:000035419
yBUB1/Phos:CDK-1
UniProtKB:P41695, Thr-566, MOD:00047 | BUB1p phosphorylated		 acts_upstream_of_or_withinNOT GO:0031577 spindle checkpoint signaling PMID:21298086
PR:000035421
hBUB1/Phos:10
UniProtKB:O43683-1, Ser-314, MOD:00046 | hBUB1 phosphorylated		 acts_upstream_of_or_withinGO:0006281 DNA repair PMID:22071147
GO:0031577 spindle checkpoint signaling PMID:22099307
enablesincreased GO:0004672 protein kinase activity relative to PR:000035405 hBUB1/PhosRes- PMID:22071147
located_inGO:0035861 site of double-strand break PMID:22071147
PR:O08901
mBUB1
Bub1 | BUB1A (mouse)		 acts_upstream_of_or_withinGO:0043069 negative regulation of programmed cell death PMID:20057499
located_inGO:0000775 chromosome, centromeric region PMID:19965387
PR:O43683
hBUB1
BUB1 | BUB1L | BUB1A (human)		 acts_upstream_of_or_withinGO:0007059 chromosome segregation PMID:16580887
GO:0007062 sister chromatid cohesion PMID:16580887
GO:0031577 spindle checkpoint signaling PMID:15525512
GO:0043066 negative regulation of apoptotic process PMID:19252416
GO:0043069 negative regulation of programmed cell death PMID:20057499
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
enablesGO:0004672 protein kinase activity PMID:10198256
GO:0005515 protein binding with PR:O60566 BUB1B PMID:10198256
GO:0005515 protein binding with PR:P04637-1 PMID:10198256
GO:0005515 protein binding with PR:P25054 APC PMID:10198256
GO:0005515 protein binding with PR:P53350 hPLK1 PMID:10198256
GO:0005515 protein binding with PR:Q8NG31 AF15q14 (human) PMID:10198256
GO:0005515 protein binding with PR:Q9Y6D9 hMAD1 PMID:10198256
GO:0005515 protein binding PMID:10198256
located_inGO:0000776 kinetochore PMID:20624902
GO:0000939 inner kinetochore PMID:11792804
GO:0000940 outer kinetochore PMID:11792804; PMID:16760428
PR:Q98UH3
frog-BUB1/var:1
 acts_upstream_of_or_withinGO:0034501 protein localization to kinetochore PMID:12163471
enablesGO:0005515 protein binding with PR:Q9YGY3 bub3 PMID:11231148
located_inGO:0000776 kinetochore PMID:11231148; PMID:12163471
GO:0005694 chromosome PMID:15241477; PMID:16950116