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Protein Ontology report - bifunctional glutamate/proline--tRNA ligase
PR:000007144 - http://purl.obolibrary.org/obo/PR_000007144
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000007144   
  PRO namebifunctional glutamate/proline--tRNA ligase 
  Synonyms
PRO-Short-label: EXACT:EPRS1
Gene-based: RELATED:EPRS | GLNS | PARS | PIG32 | QARS | QPRS
Other: EXACT:cell proliferation-inducing gene 32 protein
RELATED:bifunctional aminoacyl-tRNA synthetase
  Definition"A protein that is a translation product of the human EPRS1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 13                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000007144 bifunctional glutamate/proline--tRNA ligase, EPRS1

organism-gene


PR:P07814 bifunctional glutamate/proline--tRNA ligase (human), hEPRS1

Yes
organism-sequence


PR:P07814-1 bifunctional glutamate/proline--tRNA ligase isoform 1 (human), hEPRS/iso:1

organism-modification


PR:000037787 bifunctional glutamate/proline--tRNA ligase phosphorylated 1 (human), hEPRS/Phos:1

organism-modification


PR:000037788 bifunctional glutamate/proline--tRNA ligase unphosphorylated 1 (human), hEPRS/UnPhos:1

organism-modification


PR:000065327 bifunctional glutamate/proline--tRNA ligase methylated 1 (human), hEPRS1/Me:1

organism-modification


PR:000067109 bifunctional glutamate/proline--tRNA ligase methylated 2 (human), hEPRS1/Me:2

organism-modification


PR:000068607 bifunctional glutamate/proline--tRNA ligase phosphorylated 2 (human), hEPRS1/Phos:2

organism-modification


PR:000071309 bifunctional glutamate/proline--tRNA ligase deaminated 1 (human), hEPRS1/Deam:1

organism-modification


PR:000072996 bifunctional glutamate/proline--tRNA ligase methylated 3 (human), hEPRS1/Me:3

organism-modification


PR:000075361 bifunctional glutamate/proline--tRNA ligase cysteinylated 1 (human), hEPRS1/Cyst:1

organism-modification


PR:000075729 bifunctional glutamate/proline--tRNA ligase deaminated 2 (human), hEPRS1/Deam:2

organism-modification


PR:000078261 bifunctional glutamate/proline--tRNA ligase methylated 4 (human), hEPRS1/Me:4

organism-modification


PR:000083424 bifunctional glutamate/proline--tRNA ligase deaminated 3 (human), hEPRS1/Deam:3

organism-gene


PR:P28668 bifunctional glutamate/proline--tRNA ligase (fruit fly), fly-EPRS1

organism-sequence


PR:P28668-1 bifunctional glutamate/proline--tRNA ligase isoform A (fruit fly), fly-EPRS1/iso:A

organism-sequence


PR:P28668-2 bifunctional glutamate/proline--tRNA ligase isoform B (fruit fly), fly-EPRS1/iso:B

organism-gene


PR:Q23315 ZC434.5 (worm), EPRS (worm)

organism-gene


PR:Q8CGC7 bifunctional glutamate/proline--tRNA ligase (mouse), mEPRS

organism-sequence


PR:Q8CGC7-1 bifunctional glutamate/proline--tRNA ligase isoform 1 (mouse), mEPRS/iso:1

organism-modification


PR:000037785 bifunctional glutamate/proline--tRNA ligase phosphorylated 1 (mouse), mEPRS/Phos:1
Yes
Yes
organism-modification


PR:000037786 bifunctional glutamate/proline--tRNA ligase unphosphorylated 1 (mouse), mEPRS/UnPhos:1
Yes
sequence


PR:000038719 bifunctional glutamate/proline--tRNA ligase isoform 1, EPRS/iso:1

organism-sequence


PR:P07814-1 bifunctional glutamate/proline--tRNA ligase isoform 1 (human), hEPRS/iso:1

organism-sequence


PR:Q8CGC7-1 bifunctional glutamate/proline--tRNA ligase isoform 1 (mouse), mEPRS/iso:1

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EPRS1 forms found in complexes   

EPRS1 Component
 Complexes
PR:000037785 mEPRS/Phos:1 PR:000037795 GAIT complex (mouse)
PR:P07814 hEPRS1 PR:000027407 aminoacyl-tRNA synthetase multienzyme complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037785 mEPRS/Phos:1
UniProtKB:Q8CGC7, Ser-999, MOD:00046 | mEPRS phosphorylated
"A bifunctional glutamate/proline--tRNA ligase (mouse) that has been phosphorylated on a Ser residue in the noncatalytic linker connecting the synthetase cores in an IFN-gamma-dependent manner. UniProtKB:Q8CGC7, Ser-999, MOD:00046." [PMID:23071094, PRO:HJD]		 acts_upstream_of_or_withinGO:0071346 cellular response to type II interferon MGI:5466658; PMID:23071094
located_inGO:0097452 GAIT complex MGI:5466658; PMID:23071094
PR:000037786 mEPRS/UnPhos:1
UniProtKB:Q8CGC7, Ser-999, PR:000026291 | mEPRS unphosphorylated
"A bifunctional glutamate/proline--tRNA ligase (mouse) that lacks phosphorylation at the position equivalent to Ser-999 of the amino acid sequence represented by UniProtKB:Q8CGC7. UniProtKB:Q8CGC7, Ser-999, PR:000026291." [PMID:23071094, PRO:HJD]		 located_inGO:0017101 aminoacyl-tRNA synthetase multienzyme complex MGI:5466658; PMID:23071094
NOT GO:0097452 GAIT complex MGI:5466658; PMID:23071094