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Protein Ontology report - receptor-interacting serine/threonine-protein kinase 1
PR:000014022 - http://purl.obolibrary.org/obo/PR_000014022
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000014022   
  PRO namereceptor-interacting serine/threonine-protein kinase 1 
  Synonyms
PRO-Short-label: EXACT:RIPK1
Gene-based: RELATED:Rinp | RIP | RIP1
Other: EXACT:cell death protein RIP | receptor-interacting protein 1 | RIP-1 | serine/threonine-protein kinase RIP
  Definition"A protein that is a translation product of the human RIPK1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 7                                        
         Modification3                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038820;IUPHARobj:2189
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000014022 receptor-interacting serine/threonine-protein kinase 1, RIPK1

organism-gene


PR:Q13546 receptor-interacting serine/threonine-protein kinase 1 (human), hRIPK1

Yes
organism-sequence


PR:000060700 receptor-interacting serine/threonine-protein kinase 1 sequence variant D324N (human), hRIPK1/var:D324N

organism-sequence


PR:000061515 receptor-interacting serine/threonine-protein kinase 1 sequence variant D324V (human), hRIPK1/var:D324V

organism-sequence


PR:000061610 receptor-interacting serine/threonine-protein kinase 1 sequence variant D324Y (human), hRIPK1/var:D324Y

organism-sequence


PR:000062596 receptor-interacting serine/threonine-protein kinase 1 sequence variant D324H (human), hRIPK1/var:D324H

organism-sequence


PR:Q13546-1 receptor-interacting serine/threonine-protein kinase 1 isoform 1 (human), hRIPK1/iso:1

organism-modification


PR:000036649 receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated 1 (human), hRIPK1/iso:1/Ubiq:1
Yes
organism-sequence


PR:Q13546-2 receptor-interacting serine/threonine-protein kinase 1 isoform h2 (human), hRIPK1/iso:h2

organism-modification


PR:000036051 receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 (human), hRIPK1/K63polyUbiq:1
Yes
Yes
organism-modification


PR:000049045 receptor-interacting serine/threonine-protein kinase 1 phosphoserine form (human), hRIPK1/PhosSer+

organism-modification


PR:000062016 receptor-interacting serine/threonine-protein kinase 1 phosphorylated 1 (human), hRIPK1/Phos:1

organism-modification


PR:000063041 receptor-interacting serine/threonine-protein kinase 1 phosphorylated 2 (human), hRIPK1/Phos:2

organism-modification


PR:000064671 receptor-interacting serine/threonine-protein kinase 1 ubiquitinated 1 (human), hRIPK1/Ubiq:1

organism-modification


PR:000064778 receptor-interacting serine/threonine-protein kinase 1 ubiquitinated form (human), hRIPK1/UbiqLys+

organism-modification


PR:000064853 receptor-interacting serine/threonine-protein kinase 1 ubiquitinated 2 (human), hRIPK1/Ubiq:2

organism-modification


PR:000069926 receptor-interacting serine/threonine-protein kinase 1 methylated 1 (human), hRIPK1/Me:1

organism-modification


PR:000075119 receptor-interacting serine/threonine-protein kinase 1 cysteinylated 1 (human), hRIPK1/Cyst:1

organism-gene


PR:Q60855 receptor-interacting serine/threonine-protein kinase 1 (mouse), mRIPK1

Yes
organism-sequence


PR:Q60855-1 receptor-interacting serine/threonine-protein kinase 1 isoform 1 (mouse), mRIPK1/iso:1

organism-modification


PR:000036107 receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 (mouse), mRIPK1/K63polyUbiq:1

Yes
sequence


PR:000021967 receptor-interacting serine/threonine-protein kinase 1 isoform 1, RIPK1/iso:1

organism-sequence


PR:Q13546-1 receptor-interacting serine/threonine-protein kinase 1 isoform 1 (human), hRIPK1/iso:1

organism-modification


PR:000036649 receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated 1 (human), hRIPK1/iso:1/Ubiq:1
Yes
organism-sequence


PR:Q60855-1 receptor-interacting serine/threonine-protein kinase 1 isoform 1 (mouse), mRIPK1/iso:1

modification


PR:000021969 receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated form, RIPK1/iso:1/UbiqLys+

modification


PR:000021970 receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated 1, RIPK1/iso:1/Ubiq:1

organism-modification


PR:000036649 receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated 1 (human), hRIPK1/iso:1/Ubiq:1
Yes
modification


PR:000036050 receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1, RIPK1/K63polyUbiq:1

organism-modification


PR:000036051 receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 (human), hRIPK1/K63polyUbiq:1
Yes
Yes
organism-modification


PR:000036107 receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 (mouse), mRIPK1/K63polyUbiq:1

Yes
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RIPK1 forms found in complexes   

RIPK1 Component
 Complexes
PR:000036051 hRIPK1/K63polyUbiq:1 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000036107 mRIPK1/K63polyUbiq:1 PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036111 K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036114 IkappaB kinase:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036117 pIKBK:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:Q13546 hRIPK1 PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
PR:000028434 TRAF2:TRADD:RIP1 complex (human)
PR:000028435 TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human)
PR:000028437 TRAF2:TRADD:RIP1:FADD (human)
PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037334 rip1:ticam1:activated TLR3 complex (human)
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
PR:Q60855 mRIPK1 PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036051 hRIPK1/K63polyUbiq:1
UniProtKB:Q13546, Lys-377, PR:000044772 | K-63 polyubiquitinated RIP1 (human) | K63-linked polyUb - RIP1 (human) | K63polyUb-RIP1 (human) | K63polyUb-RIPK1 (human)
"A receptor-interacting serine/threonine-protein kinase 1 K63-polyubiquitinated 1 in human. UniProtKB:Q13546, Lys-377, PR:000044772." [Reactome:R-HSA-937021]		 located_inGO:0005737 cytoplasm Reactome:REACT_26236
PR:000036649 hRIPK1/iso:1/Ubiq:1

"A receptor-interacting serine/threonine-protein kinase 1 isoform 1 ubiquitinated 1 in human." [PMID:19734906, PRO:CNA]		 enablesGO:0005515 protein binding with PR:Q8C669 mPELI1 PMID:19734906