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Protein Ontology report - sonic hedgehog protein
PR:000014841 - http://purl.obolibrary.org/obo/PR_000014841
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000014841   
  PRO namesonic hedgehog protein 
  Synonyms
PRO-Short-label: EXACT:SHH
Gene-based: RELATED:Hhg1
Other: EXACT:HHG-1 | Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains | ShhNC
  Definition"A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification4                                                  Organism-Modification 30                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000014841 sonic hedgehog protein, SHH

organism-gene


PR:Q15465 sonic hedgehog protein (human), hSHH

organism-modification


PR:000037274 sonic hedgehog protein N-product dually lipidated 1 (human), hSHH/Clv:Nter/2*Lipid:1

organism-modification


PR:000060317 sonic hedgehog protein sequence variant L382P, signal peptide removed form (human), hSHH/var:L382P/SigPep-

organism-modification


PR:000060418 sonic hedgehog protein sequence variant G196V, signal peptide removed form (human), hSHH/var:G196V/SigPep-

organism-modification


PR:000060438 sonic hedgehog protein sequence variant C198S, signal peptide removed ubiquitinated form (human), hSHH/var:C198S/SigPep-/UbiqLys+

organism-modification


PR:000060458 sonic hedgehog protein sequence variant G196V, signal peptide removed ubiquitinated form (human), hSHH/var:G196V/SigPep-/UbiqLys+

organism-modification


PR:000060483 sonic hedgehog protein sequence variant W117G, signal peptide removed ubiquitinated form (human), hSHH/var:W117G/SigPep-/UbiqLys+

organism-modification


PR:000060485 sonic hedgehog protein sequence variant W117G, signal peptide removed form (human), hSHH/var:W117G/SigPep-

organism-modification


PR:000060562 sonic hedgehog protein sequence variant W117R, signal peptide removed form (human), hSHH/var:W117R/SigPep-

organism-modification


PR:000060621 sonic hedgehog protein sequence variant A373T, signal peptide removed form (human), hSHH/var:A373T/SigPep-

organism-modification


PR:000060800 sonic hedgehog protein sequence variant F377S, signal peptide removed form (human), hSHH/var:F377S/SigPep-

organism-modification


PR:000060869 sonic hedgehog protein sequence variant R381P, signal peptide removed ubiquitinated form (human), hSHH/var:R381P/SigPep-/UbiqLys+

organism-modification


PR:000061125 sonic hedgehog protein sequence variant A376D, signal peptide removed form (human), hSHH/var:A376D/SigPep-

organism-modification


PR:000061219 sonic hedgehog protein sequence variant F377S, signal peptide removed ubiquitinated form (human), hSHH/var:F377S/SigPep-/UbiqLys+

organism-modification


PR:000061558 sonic hedgehog protein sequence variant G196E, signal peptide removed form (human), hSHH/var:G196E/SigPep-

organism-modification


PR:000061958 sonic hedgehog protein sequence variant A383T, signal peptide removed form (human), hSHH/var:A383T/SigPep-

organism-modification


PR:000062404 sonic hedgehog protein sequence variant C198S, signal peptide removed form (human), hSHH/var:C198S/SigPep-

organism-modification


PR:000062597 sonic hedgehog protein sequence variant G196E, signal peptide removed ubiquitinated form (human), hSHH/var:G196E/SigPep-/UbiqLys+

organism-modification


PR:000062637 sonic hedgehog protein sequence variant A383T, signal peptide removed ubiquitinated form (human), hSHH/var:A383T/SigPep-/UbiqLys+

organism-modification


PR:000062821 sonic hedgehog protein sequence variant A376D, signal peptide removed ubiquitinated form (human), hSHH/var:A376D/SigPep-/UbiqLys+

organism-modification


PR:000062925 sonic hedgehog protein sequence variant A373T, signal peptide removed ubiquitinated form (human), hSHH/var:A373T/SigPep-/UbiqLys+

organism-modification


PR:000063074 sonic hedgehog protein sequence variant W117R, signal peptide removed ubiquitinated form (human), hSHH/var:W117R/SigPep-/UbiqLys+

organism-modification


PR:000063484 sonic hedgehog protein, signal peptide removed form (human), hSHH/SigPep-

organism-modification


PR:000063556 sonic hedgehog protein sequence variant R381P, signal peptide removed form (human), hSHH/var:R381P/SigPep-

organism-modification


PR:000063771 sonic hedgehog protein sequence variant C198F, signal peptide removed ubiquitinated form (human), hSHH/var:C198F/SigPep-/UbiqLys+

organism-modification


PR:000063895 sonic hedgehog protein sequence variant C198F, signal peptide removed form (human), hSHH/var:C198F/SigPep-

organism-modification


PR:000064527 sonic hedgehog protein sequence variant H374R, signal peptide removed form (human), hSHH/var:H374R/SigPep-

organism-modification


PR:000064548 sonic hedgehog protein sequence variant L382P, signal peptide removed ubiquitinated form (human), hSHH/var:L382P/SigPep-/UbiqLys+

organism-modification


PR:000064560 sonic hedgehog protein sequence variant H374R, signal peptide removed ubiquitinated form (human), hSHH/var:H374R/SigPep-/UbiqLys+

organism-gene


PR:Q62226 sonic hedgehog protein (mouse), mSHH

organism-modification


PR:000037272 sonic hedgehog protein, signal peptide removed form (mouse), mSHH/SigPep-

organism-modification


PR:000037269 sonic hedgehog protein N-product dually lipidated 1 (mouse), mSHH/Clv:Nter/2*Lipid:1
Yes
organism-gene


PR:Q63673 sonic hedgehog protein (rat), rSHH

organism-gene


PR:Q91035 sonic hedgehog protein (chicken), chick-SHH

organism-gene


PR:Q92008 sonic hedgehog protein (zebrafish), z-SHH

modification


PR:000021467 sonic hedgehog protein, signal peptide removed form, SHH/SigPep-

modification


PR:000037273 sonic hedgehog protein N-product, SHH/Clv:Nter

organism-modification


PR:000037269 sonic hedgehog protein N-product dually lipidated 1 (mouse), mSHH/Clv:Nter/2*Lipid:1
Yes
organism-modification


PR:000037274 sonic hedgehog protein N-product dually lipidated 1 (human), hSHH/Clv:Nter/2*Lipid:1

modification


PR:000037275 sonic hedgehog protein C-product, SHH/Clv:Cter

organism-modification


PR:000037272 sonic hedgehog protein, signal peptide removed form (mouse), mSHH/SigPep-

organism-modification


PR:000037269 sonic hedgehog protein N-product dually lipidated 1 (mouse), mSHH/Clv:Nter/2*Lipid:1
Yes
modification


PR:000021468 sonic hedgehog protein proteolytic cleavage product, SHH/ClvPrd

modification


PR:000037273 sonic hedgehog protein N-product, SHH/Clv:Nter

organism-modification


PR:000037269 sonic hedgehog protein N-product dually lipidated 1 (mouse), mSHH/Clv:Nter/2*Lipid:1
Yes
organism-modification


PR:000037274 sonic hedgehog protein N-product dually lipidated 1 (human), hSHH/Clv:Nter/2*Lipid:1

modification


PR:000037275 sonic hedgehog protein C-product, SHH/Clv:Cter

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037269 mSHH/Clv:Nter/2*Lipid:1
UniProtKB:Q62226, 25-198, Cys-25, MOD:00069|Gly-198, MOD:00314
"A sonic hedgehog protein N-product in mouse that has been further modified on the N-terminal Cys residue by palmitoylation and the C-terminal Gly residue by cholesterylation. UniProtKB:Q62226, 25-198, Cys-25, MOD:00069|Gly-198, MOD:00314." [PMID:15075292, PMID:8824192, PRO:KRC]		 acts_upstream_of_or_withinGO:0007224 smoothened signaling pathway MGI:3039193; PMID:15075292
GO:0009952 anterior/posterior pattern specification MGI:2135419; PMID:11389830
GO:0030326 embryonic limb morphogenesis MGI:2135419; PMID:11389830
GO:0042733 embryonic digit morphogenesis MGI:3039193; PMID:15075292