Protein Ontology

Home

Linked Open Data

Browse

Statistics

Download

RACE-PRO

PRO tracker

Community

PRO Consortium

Publications

Documentation

Protein Ontology report - serine palmitoyltransferase 2

PR:000015597 - http://purl.obolibrary.org/obo/PR_000015597

Protein Forms

Complex

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000015597

PRO name

serine palmitoyltransferase 2

Synonyms

PRO-Short-label:	EXACT:	SPTLC2
Gene-based:	RELATED:	KIAA0526 \| LCB2
Other:	EXACT:	LCB 2 \| LCB2a \| long chain base biosynthesis protein 2 \| long chain base biosynthesis protein 2a \| serine-palmitoyl-CoA transferase 2 \| SPT 2

Definition

"A eukaryotic serine palmitoyltransferase that is a translation product of the human SPTLC2 gene or a 1:1 ortholog thereof." [PRO:CNA]

PRO Category

gene

Parent

PR:000026126 eukaryotic serine palmitoyltransferase

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	3
Sequence	1	Organism-Sequence	2
Modification	0	Organism-Modification	3

Term Hierarchy
Visualization

DAG:

OLS:

Back to top

Related Cross References
Db identifiers	IUPHARobj:2510

Back to top

Protein Forms

Switch to Extended View

Category

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000015597 serine palmitoyltransferase 2, SPTLC2

organism-gene

PR:O15270 serine palmitoyltransferase 2 (human), hSPTLC2

Yes

organism-sequence

PR:O15270-1 serine palmitoyltransferase 2 isoform 1 (human), hSPTLC2/iso:1

organism-modification

PR:000049342 serine palmitoyltransferase 2 pyridoxal phosphate lysine 1 (human), hSPTLC2/Pyrdox:1

organism-modification

PR:000073274 serine palmitoyltransferase 2 methylated 1 (human), hSPTLC2/Me:1

organism-modification

PR:000083083 serine palmitoyltransferase 2 methylated 2 (human), hSPTLC2/Me:2

organism-gene

PR:P97363 serine palmitoyltransferase 2 (mouse), mSPTLC2

Yes

organism-sequence

PR:P97363-1 serine palmitoyltransferase 2 isoform 1 (mouse), mSPTLC2/iso:1

Yes

organism-gene

PR:Q3B7D2 serine palmitoyltransferase 2 (rat), rSPTLC2

sequence

PR:000022020 serine palmitoyltransferase 2 isoform 1, SPTLC2/iso:1

organism-sequence

PR:O15270-1 serine palmitoyltransferase 2 isoform 1 (human), hSPTLC2/iso:1

organism-sequence

PR:P97363-1 serine palmitoyltransferase 2 isoform 1 (mouse), mSPTLC2/iso:1

Yes

Back to top

SPTLC2 forms found in complexes

SPTLC2 Component	Complexes
PR:O15270 hSPTLC2	PR:000026144 serine palmitoyltransferase complex core 1 (human)
	PR:000026153 serine palmitoyltransferase complex 5 (human)
	PR:000026154 serine palmitoyltransferase complex 6 (human)
	PR:000026155 serine palmitoyltransferase complex A (human)
PR:P97363 mSPTLC2	PR:000025761 serine palmitoyltransferase complex (mouse)
PR:P97363 mSPTLC2	PR:000025762 serine palmitoyltransferase complex A (mouse)

Back to top

Functional Annotation (PRO-centric view)

Switch to GO Centric View

PRO Term	GO Annotation		Evidence
PR:P97363 mSPTLC2 Lcb2 \| Sptlc2 \| LCB 2 (mouse) \| LCB2a (mouse) \| long chain base biosynthesis protein 2 (mouse) \| long chain base biosynthesis protein 2a (mouse) \| serine-palmitoyl-CoA transferase 2 (mouse) \| SPT 2 (mouse) "A serine palmitoyltransferase 2 that is encoded in the genome of mouse." [OMA:P97363, PRO:HJD]	acts_upstream_of_or_within	GO:0006686 sphingomyelin biosynthetic process	PMID:16216550
		GO:0046512 sphingosine biosynthetic process	PMID:16216550
		GO:0046513 ceramide biosynthetic process	PMID:16216550
PR:P97363-1 mSPTLC2/iso:1 "A serine palmitoyltransferase 2 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]	acts_upstream_of_or_within	GO:0046511 sphinganine biosynthetic process	PMID:9363775
	enables	GO:0004758 serine C-palmitoyltransferase activity	PMID:9363775
	located_in	GO:0005739 mitochondrion	PMID:18614015