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Documentation
Protein Ontology report - dual specificity protein kinase TTK
PR:000016787 -
http://purl.obolibrary.org/obo/PR_000016787
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000016787
PRO name
dual specificity protein kinase TTK
Synonyms
PRO-Short-label
:
EXACT:
TTK
Gene-based
:
RELATED:
MPS1 | MPS1L1
Other
:
EXACT:
ESK | Monopolar spindle protein 1 | phosphotyrosine picked threonine-protein kinase | PYT | Regulatory cell proliferation kinase 1
RELATED:
RPK1 | serine/threonine-protein kinase MPS1
Definition
"A protein that is a translation product of the human TTK gene or a 1:1 ortholog thereof." [PRO:DNx]
PRO Category
gene
Parent
PR:000000001
protein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
4
Sequence
0
Organism-Sequence
4
Modification
0
Organism-Modification
7
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
IUPHARobj:2264
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
gene
PR:000016787
dual specificity protein kinase TTK, TTK
organism-gene
PR:P33981
dual specificity protein kinase TTK (human), hTTK
Yes
organism-sequence
PR:P33981-1
dual specificity protein kinase TTK isoform h1 (human), hTTK/iso:h1
organism-sequence
PR:P33981-2
dual specificity protein kinase TTK isoform h2 (human), hTTK/iso:h2
organism-modification
PR:000045754
dual specificity protein kinase TTK phosphorylated 1 (human), hTTK/Phos:1
Yes
organism-modification
PR:000049844
TTK activation loop phosphorylated form (human), hTTK/(Act-loop)Phos+
Yes
organism-modification
PR:000049845
TTK activation loop and P+1 loop phosphorylated form (human), hTTK/(Act-loop_P+1-loop)Phos+
Yes
organism-modification
PR:000083646
dual specificity protein kinase TTK methylated 1 (human), hTTK/Me:1
organism-gene
PR:P35761
dual specificity protein kinase TTK (mouse), mTTK
organism-sequence
PR:P35761-1
dual specificity protein kinase TTK isoform m1 (mouse), mTTK/iso:m1
organism-sequence
PR:P35761-2
dual specificity protein kinase TTK isoform m2 (mouse), mTTK/iso:m2
organism-modification
PR:000049885
dual specificity protein kinase TTK isoform m2 phosphorylated 1 (mouse), mTTK/iso:m2/Phos:1
organism-modification
PR:000049886
dual specificity protein kinase TTK isoform m2 phosphorylated 2 (mouse), mTTK/iso:m2/Phos:2
organism-modification
PR:000049884
dual specificity protein kinase TTK phosphorylated 1 (mouse), mTTK/Phos:1
organism-gene
PR:P54199
serine/threonine-protein kinase MPS1 (yeast), yTTK
Yes
organism-gene
PR:Q8AYG3
dual specificity protein kinase Ttk (zebrafish), z-TTK
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000045754
hTTK/Phos:1
UniProtKB:P33981, Thr-676, MOD:00047 | UniProtKB:P33981-1, Thr-676, MOD:00047
"A dual specificity protein kinase TTK (human) that has been phosphorylated on the residue at the position equivalent to Thr-676 of the amino acid sequence represented by UniProtKB:P33981-1. Example: UniProtKB:P33981-1, Thr-676, MOD:00047." [iPTMnet:P33981, PMID:18083840, PMID:18680479, PMID:19120698, PRO:KER]
acts_upstream_of_or_within
GO:0046777
protein autophosphorylation
PMID:18680479
;
PMID:19120698
GO:0051298
centrosome duplication
PMID:17728254
GO:0071174
mitotic spindle checkpoint signaling
PMID:18083840
enables
GO:0004672
protein kinase activity
PMID:18680479
PR:000049844
hTTK/(Act-loop)Phos+
UniProtKB:P33981, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046) | UniProtKB:P33981, Ser-677, MOD:00046 | UniProtKB:P33981, Thr-675, MOD:00047 | UniProtKB:P33981, Thr-676, MOD:00047 | UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046) | UniProtKB:P33981-1, Ser-677, MOD:00046 | UniProtKB:P33981-1, Thr-675, MOD:00047 | UniProtKB:P33981-1, Thr-676, MOD:00047
"A dual specificity protein kinase TTK (human) that has been phosphorylated on one of three sites within the activation loop, at positions equivalent to Thr-675 or Thr-676 or Ser-677 of the amino acid sequence represented by UniProtKB:P33981-1. Example: UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)." [PMID:17728254, PMID:18923149, PMID:19120698, PRO:KER]
acts_upstream_of_or_within
GO:0046777
protein autophosphorylation
PMID:18680479
;
PMID:19120698
enables
GO:0004672
protein kinase activity
PMID:18680479
;
PMID:19120698
PR:000049845
hTTK/(Act-loop_P+1-loop)Phos+
UniProtKB:P33981, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)|Thr-686, MOD:00047 | UniProtKB:P33981, Ser-677, MOD:00046|Thr-686, MOD:00047 | UniProtKB:P33981, Thr-675, MOD:00047|Thr-686, MOD:00047 | UniProtKB:P33981, Thr-676, MOD:00047|Thr-686, MOD:00047 | UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)|Thr-686, MOD:00047 | UniProtKB:P33981-1, Ser-677, MOD:00046|Thr-686, MOD:00047 | UniProtKB:P33981-1, Thr-675, MOD:00047|Thr-686, MOD:00047 | UniProtKB:P33981-1, Thr-676, MOD:00047|Thr-686, MOD:00047
"A dual specificity protein kinase TTK (human) that has been phosphorylated on one of three sites within the activation loop and on a Thr residue in the P+1 loop. Example: UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)|Thr-686, MOD:00047." [PMID:19120698, PRO:KER]
enables
GO:0004672
protein kinase activity
PMID:19120698
PR:P33981
hTTK
MPS1 | MPS1L1 | TTK | phosphotyrosine picked threonine-protein kinase (human) | PYT (human)
"A dual specificity protein kinase TTK that is encoded in the genome of human." [PMID:20823832, PRO:KER]
acts_upstream_of_or_within
GO:0031577
spindle checkpoint signaling
PMID:20624902
GO:0032092
positive regulation of protein binding
PMID:22660415
GO:0032092
positive regulation of protein binding
PMID:22660415
NOT
GO:0034501
protein localization to kinetochore
PMID:20624902
NOT
GO:0034501
protein localization to kinetochore
PMID:20624902
NOT
GO:0034501
protein localization to kinetochore
PMID:20624902
NOT
GO:0034501
protein localization to kinetochore
PMID:20624902
NOT
GO:0034501
protein localization to kinetochore
PMID:20624902
NOT
GO:0034501
protein localization to kinetochore
PMID:20624902
NOT
GO:0034501
protein localization to kinetochore
PMID:20624902
NOT
GO:0034501
protein localization to kinetochore
PMID:20624902
NOT
GO:0034501
protein localization to kinetochore
PMID:20624902
NOT
GO:0034501
protein localization to kinetochore
PMID:20624902
NOT
GO:0034501
protein localization to kinetochore
PMID:20624902
NOT
GO:0034501
protein localization to kinetochore
PMID:20624902
GO:0045841
negative regulation of mitotic metaphase/anaphase transition
PMID:20624902
GO:0051310
metaphase chromosome alignment
PMID:20624902
;
PMID:22732840
enables
GO:0005515
protein binding
with
PR:Q12834
CDC20
BioGRID:BG-590746
located_in
GO:0000776
kinetochore
PMID:20624902
PR:P54199
yTTK
D2785 | MPS1 | RPK1 | YDL028C | monopolar spindle protein 1 (yeast) | regulatory cell proliferation kinase 1 (yeast)
"A dual specificity protein kinase TTK that is encoded in the genome of yeast." [PMID:22521787, PMID:8688079, PRO:KER]
acts_upstream_of_or_within
GO:0031577
spindle checkpoint signaling
PMID:8688079
GO:0034501
protein localization to kinetochore
PMID:22521787
GO:0034501
protein localization to kinetochore
PMID:22521787
enables
GO:0004672
protein kinase activity
PMID:22521787
;
PMID:8688079