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Protein Ontology report - TGF-beta 1 proteolytic cleavage product
PR:000018292 - http://purl.obolibrary.org/obo/PR_000018292
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000018292   
  PRO nameTGF-beta 1 proteolytic cleavage product 
  Synonyms
PRO-Short-label: EXACT:TGFB1/ClvPrd
  Definition"A TGF-beta 1 that has been processed by proteolytic cleavage." [PRO:DNx] 
  PRO Categorymodification 
  ParentPR:000000182
PR:000018264
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification3                                                  Organism-Modification 15                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000018292 TGF-beta 1 proteolytic cleavage product, TGFB1/ClvPrd

modification


PR:000000616 TGF-beta 1 isoform 1 mature form, TGFB1/iso:1/mature

Yes
organism-modification


PR:000025927 TGF-beta 1 isoform 1 mature form (human), hTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025928 TGF-beta 1 isoform 1 mature form (mouse), mTGFB1/iso:1/mature
Yes
organism-modification


PR:000025929 TGF-beta 1 isoform 1 mature form (rat), rTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000025930 TGF-beta 1 isoform 1 mature form (green monkey), GrMonkey-TGFB1/iso:1/mature
Yes
modification


PR:000000617 TGF-beta 1 isoform 1 latency associated peptide, TGFB1/iso:1/LAP

organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
organism-modification


PR:000000619 TGF-beta 1 sequence variant T81H cleaved 1 (human), hTGFB1/var:T81H/Clv:1
Yes
organism-modification


PR:000000620 TGF-beta 1 sequence variant T81H cleaved 2 (human), hTGFB1/var:T81H/Clv:2
Yes
organism-modification


PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human), hTGFB1/var:R218C/Clv:1
Yes
organism-modification


PR:000000622 TGF-beta 1 sequence variant R218C cleaved 2 (human), hTGFB1/var:R218C/Clv:2
Yes
organism-modification


PR:000000623 TGF-beta 1 sequence variant H222D cleaved 1 (human), hTGFB1/var:H222D/Clv:1
Yes
organism-modification


PR:000000624 TGF-beta 1 sequence variant H222D cleaved 2 (human), hTGFB1/var:H222D/Clv:2
Yes
organism-modification


PR:000000625 TGF-beta 1 sequence variant C225R cleaved 1 (human), hTGFB1/var:C225R/Clv:1
Yes
organism-modification


PR:000000626 TGF-beta 1 sequence variant C225R cleaved 2 (human), hTGFB1/var:C225R/Clv:2
Yes
organism-modification


PR:000000627 TGF-beta 1 sequence variant R218H cleaved 1 (human), hTGFB1/var:R218H/Clv:1
Yes
organism-modification


PR:000000628 TGF-beta 1 sequence variant R218H cleaved 2 (human), hTGFB1/var:R218H/Clv:2
Yes
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TGFB1/ClvPrd forms found in complexes   

TGFB1/ClvPrd Component
 Complexes
PR:000000616 TGFB1/iso:1/mature PR:000025925
PR:000025927 hTGFB1/iso:1/mature PR:000025926
PR:000025929 rTGFB1/iso:1/mature PR:000025931
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000619
hTGFB1/var:T81H/Clv:1
UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979 | TGF-beta 1 sequence variant 2 cleaved 1 (human)		 located_inSO:0001558 polypeptide_localization_variant PMID:12493741
PR:000000620
hTGFB1/var:T81H/Clv:2
UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979 | TGF-beta 1 sequence variant 2 cleaved 2 (human)		 located_inGO:0005615 extracellular space PMID:12493741
PR:000000621
hTGFB1/var:R218C/Clv:1
UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 cleaved 1 (human)		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463; PMID:12493741; PMID:12843182
enablesGO:0005160 transforming growth factor beta receptor binding PMID:11278244
increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:11062463; PMID:12493741; PMID:12843182
GO:0042803 protein homodimerization activity PMID:11062463; PMID:12493741; PMID:12843182
located_inGO:0005615 extracellular space PMID:11062463; PMID:12493741; PMID:12843182
PR:000000622
hTGFB1/var:R218C/Clv:2
UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 cleaved 2 (human)		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
PR:000000623
hTGFB1/var:H222D/Clv:1
UniProtKB:P01137, 279-390, His-222, CHEBI:29958 | TGF-beta 1 sequence variant 5 cleaved 1 (human)		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12493741
GO:0043066 negative regulation of apoptotic process PMID:12493741
enablesincreased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:12493741
located_inGO:0005615 extracellular space PMID:12493741
PR:000000624
hTGFB1/var:H222D/Clv:2
UniProtKB:P01137, 30-278, His-222, CHEBI:29958 | TGF-beta 1 sequence variant 5 cleaved 2 (human)		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
SO:0001601 conformational_change_variant PMID:11278244
PR:000000625
hTGFB1/var:C225R/Clv:1
UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952 | TGF-beta 1 sequence variant 6 cleaved 1 (human)		 enablesincreased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:11062463; PMID:12493741; PMID:12843182
located_inGO:0005615 extracellular space PMID:11062463; PMID:12493741; PMID:12843182
PR:000000626
hTGFB1/var:C225R/Clv:2
UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952 | TGF-beta 1 sequence variant 6 cleaved 2 (human)		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
PR:000000627
hTGFB1/var:R218H/Clv:1
UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979 | TGF-beta 1 sequence variant 4 cleaved 1 (human)		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11278244
enablesGO:0005160 transforming growth factor beta receptor binding PMID:11278244
increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:12493741; PMID:12843182
GO:0042803 protein homodimerization activity PMID:11278244
located_inGO:0005615 extracellular space PMID:11278244
PR:000000628
hTGFB1/var:R218H/Clv:2
UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979 | TGF-beta 1 sequence variant 4 cleaved 2 (human)		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244
SO:0001601 conformational_change_variant PMID:11278244
PR:000025927
hTGFB1/iso:1/mature
UniProtKB:P01137-1, 279-390 | PRO_0000033763		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8471846
GO:0043066 negative regulation of apoptotic process PMID:9918798
enablesGO:0042803 protein homodimerization activity PMID:3162913; PMID:8471846
located_inGO:0031012 extracellular matrix PMID:8294500
PR:000025928
mTGFB1/iso:1/mature
UniProtKB:P04202-1, 279-390 | PRO_0000033767		 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856
enablesGO:0005160 transforming growth factor beta receptor binding PMID:14764882
located_inGO:0031012 extracellular matrix PMID:9008713
PR:000025929
rTGFB1/iso:1/mature
UniProtKB:P17246-1, 279-390 | PRO_0000033771		 located_inGO:0031012 extracellular matrix PMID:11907708
PR:000025930
GrMonkey-TGFB1/iso:1/mature
UniProtKB:P09533-1, 279-390 | PRO_0000033761		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:3185545
enablesGO:0042803 protein homodimerization activity PMID:3185545
located_inGO:0031012 extracellular matrix PMID:3185545
PR:000036526
hTGFB1/iso:1/LAP
UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160		 located_inGO:0032991 protein-containing complex PMID:17015622; PMID:3162913