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Protein Ontology report - beta-type platelet-derived growth factor receptor, signal peptide removed form
PR:000018702 -
http://purl.obolibrary.org/obo/PR_000018702
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000018702
PRO name
beta-type platelet-derived growth factor receptor, signal peptide removed form
Synonyms
PRO-Short-label
:
EXACT:
PDGFRB/SigPep-
Definition
"A beta-type platelet-derived growth factor receptor that has had the signal peptide removed." [PRO:DNx]
PRO Category
modification
Parent
PR:000002035
beta-type platelet-derived growth factor receptor
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
3
Organism-Modification
5
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000018702
beta-type platelet-derived growth factor receptor, signal peptide removed form, PDGFRB/SigPep-
modification
PR:000002143
beta-type platelet-derived growth factor receptor isoform 2, signal peptide removed form, PDGFRB/iso:2/SigPep-
modification
PR:000026683
beta-type platelet-derived growth factor receptor isoform 1, signal peptide removed form, PDGFRB/iso:1/SigPep-
organism-modification
PR:000048725
platelet-derived growth factor receptor beta, signal peptide removed form (human), hPDGFRB/SigPep-
organism-modification
PR:000048726
platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 1 (human), hPDGFRB/SigPep-/Phos:1
organism-modification
PR:000049846
platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 2 (human), hPDGFRB/SigPep-/Phos:2
Yes
organism-modification
PR:000049847
platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 3 (human), hPDGFRB/SigPep-/Phos:3
Yes
organism-modification
PR:000049848
platelet-derived growth factor receptor beta, signal peptide removed unphosphorylated 2 (human), hPDGFRB/SigPep-/UnPhos:2
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000049846
hPDGFRB/SigPep-/Phos:2
UniProtKB:P09619, 33-1106, Tyr-857, MOD:00048 | UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048
"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and that has been phosphorylated on the residue at the position equivalent to Tyr-857 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048." [PMID:1653029, PMID:9642269, PRO:KER]
acts_upstream_of_or_within
increased
GO:0018108
peptidyl-tyrosine phosphorylation
relative to
PR:000049848
hPDGFRB/SigPep-/UnPhos:2
PMID:1653029
;
PMID:9642269
enables
GO:0004713
protein tyrosine kinase activity
PMID:15994317
;
PMID:9642269
increased
GO:0005515
protein binding
relative to
PR:000049848
hPDGFRB/SigPep-/UnPhos:2
PMID:1653029
PR:000049847
hPDGFRB/SigPep-/Phos:3
UniProtKB:P09619, 33-1106, Tyr-857, MOD:00048|Ser-1104, MOD:00046 | UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048|Ser-1104, MOD:00046
"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and that has been phosphorylated on residues at positions equivalent to Tyr-857 and Ser-1104 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048|Ser-1104, MOD:00046." [PMID:15271984, PMID:15994317, PRO:KER]
acts_upstream_of_or_within
decreased
GO:0051897
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
relative to
PR:000049846
hPDGFRB/SigPep-/Phos:2
PMID:15271984
enables
decreased
GO:0004713
protein tyrosine kinase activity
relative to
PR:000049846
hPDGFRB/SigPep-/Phos:2
PMID:15271984
decreased
GO:0005515
protein binding
relative to
PR:000049846
hPDGFRB/SigPep-/Phos:2
PMID:15271984
PR:000049848
hPDGFRB/SigPep-/UnPhos:2
UniProtKB:P09619, 33-1106, Tyr-857, PR:000026291 | UniProtKB:P09619-1, 33-1106, Tyr-857, PR:000026291
"A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and that lacks phosphorylation on the residue at the position equivalent to Tyr-857 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, PR:000026291." [PMID:1653029, PMID:9642269, PRO:KER]
acts_upstream_of_or_within
GO:0038083
peptidyl-tyrosine autophosphorylation
PMID:9642269
