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Protein Ontology report - protein kinase C beta type, initiator methionine removed form
PR:000018783 -
http://purl.obolibrary.org/obo/PR_000018783
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000018783
PRO name
protein kinase C beta type, initiator methionine removed form
Synonyms
PRO-Short-label
:
EXACT:
PRKCB/InitMet-
Definition
"A protein kinase C beta type that has had the initiator methionine removed." [PRO:DNx]
PRO Category
modification
Parent
PR:000003059
protein kinase C beta type
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
7
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000018783
protein kinase C beta type, initiator methionine removed form, PRKCB/InitMet-
organism-modification
PR:000048913
protein kinase C beta type, initiator methionine removed form (human), hPRKCB/InitMet-
organism-modification
PR:000048914
protein kinase C beta type, initiator methionine removed phosphorylated 1 (human), hPRKCB/InitMet-/Phos:1
organism-modification
PR:000048915
protein kinase C beta type, initiator methionine removed phosphorylated 2 (human), hPRKCB/InitMet-/Phos:2
organism-modification
PR:000049853
protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human), hPRKCB/iso:Beta-II/InitMet-/Phos:1
Yes
organism-modification
PR:000049854
protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human), hPRKCB/iso:Beta-II/InitMet-/UnPhos:1
organism-modification
PR:000049855
protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human), hPRKCB/iso:Beta-II/InitMet-/Phos:2
Yes
organism-modification
PR:000049856
protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human), hPRKCB/iso:Beta-II/InitMet-/UnPhos:2
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000049853
hPRKCB/iso:Beta-II/InitMet-/Phos:1
UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047
"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047." [PMID:8749392, PRO:KER]
enables
increased
GO:0004674
protein serine/threonine kinase activity
relative to
PR:000049854
hPRKCB/iso:Beta-II/InitMet-/UnPhos:1
PMID:8749392
located_in
GO:0005737
cytoplasm
PMID:9756933
GO:0005886
plasma membrane
PMID:9756933
PR:000049855
hPRKCB/iso:Beta-II/InitMet-/Phos:2
UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046
"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the activation loop, and phosphothreonine at position 641 and phosphoserine at position 660 of the Pkinase_C domain (Pfam:PF00433). UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046." [PMID:8749392, PRO:KER]
acts_upstream_of_or_within
increased
GO:0006468
protein phosphorylation
relative to
PR:000049856
hPRKCB/iso:Beta-II/InitMet-/UnPhos:2
PMID:8749392
enables
increased
GO:0001786
phosphatidylserine binding
relative to
PR:000049856
hPRKCB/iso:Beta-II/InitMet-/UnPhos:2
PMID:9218480
increased
GO:0005509
calcium ion binding
relative to
PR:000049856
hPRKCB/iso:Beta-II/InitMet-/UnPhos:2
PMID:9218480
located_in
increased
GO:0005737
cytoplasm
relative to
PR:000049856
hPRKCB/iso:Beta-II/InitMet-/UnPhos:2
PMID:9756933
