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Protein Ontology report - TGF-beta 1 sequence variant H222D, signal peptide removed form (human)
PR:000021905 -
http://purl.obolibrary.org/obo/PR_000021905
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:000021905
PRO name
TGF-beta 1 sequence variant H222D, signal peptide removed form (human)
Synonyms
PRO-Short-label
:
EXACT:
hTGFB1/var:H222D/SigPep-
PRO-proteoform-std
:
EXACT:
UniProtKB:P01137
, 30-390, His-222,
CHEBI:29958
Other
:
EXACT:
TGF-beta 1 sequence variant 5, signal peptide removed form (human)
Definition
"A TGF-beta 1 sequence variant H222D (human) that has had the signal peptide removed.
UniProtKB:P01137
, 30-390, His-222,
CHEBI:29958
." [PRO:DNx]
PRO Category
organism-modification
Parent
PR:000000402
TGF-beta 1 sequence variant H222D (human)
PR:000049430
transforming growth factor beta-1, signal peptide removed form (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
0
Organism-Modification
3
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
organism-modification
PR:000021905
TGF-beta 1 sequence variant H222D, signal peptide removed form (human), hTGFB1/var:H222D/SigPep-
organism-modification
PR:000000623
TGF-beta 1 sequence variant H222D cleaved 1 (human), hTGFB1/var:H222D/Clv:1
Yes
organism-modification
PR:000000624
TGF-beta 1 sequence variant H222D cleaved 2 (human), hTGFB1/var:H222D/Clv:2
Yes
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000623
hTGFB1/var:H222D/Clv:1
UniProtKB:P01137, 279-390, His-222, CHEBI:29958 | TGF-beta 1 sequence variant 5 cleaved 1 (human)
"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, His-222, CHEBI:29958." [PRO:CNA, PRO:DAN]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:12493741
GO:0043066
negative regulation of apoptotic process
PMID:12493741
enables
increased
GO:0008083
growth factor activity
relative to
PR:000000616
TGF-beta 1 active protein
PMID:12493741
located_in
GO:0005615
extracellular space
PMID:12493741
PR:000000624
hTGFB1/var:H222D/Clv:2
UniProtKB:P01137, 30-278, His-222, CHEBI:29958 | TGF-beta 1 sequence variant 5 cleaved 2 (human)
"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, His-222, CHEBI:29958." [PMID:11278244, PRO:CNA, PRO:DAN]
located_in
SO:0001561
polypeptide_partial_loss_of_function
PMID:11278244
SO:0001601
conformational_change_variant
PMID:11278244
