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Protein Ontology report - TGF-beta 1 sequence variant C225R, signal peptide removed form (human)
PR:000021906 -
http://purl.obolibrary.org/obo/PR_000021906
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:000021906
PRO name
TGF-beta 1 sequence variant C225R, signal peptide removed form (human)
Synonyms
PRO-Short-label
:
EXACT:
hTGFB1/var:C225R/SigPep-
PRO-proteoform-std
:
EXACT:
UniProtKB:P01137
, 30-390, Cys-225,
CHEBI:29952
Other
:
EXACT:
TGF-beta 1 sequence variant 6, signal peptide removed form (human)
Definition
"A TGF-beta 1 sequence variant C225R (human) that has had the signal peptide removed.
UniProtKB:P01137
, 30-390, Cys-225,
CHEBI:29952
." [PRO:DAN]
PRO Category
organism-modification
Parent
PR:000000403
TGF-beta 1 sequence variant C225R (human)
PR:000049430
transforming growth factor beta-1, signal peptide removed form (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
0
Organism-Modification
3
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
organism-modification
PR:000021906
TGF-beta 1 sequence variant C225R, signal peptide removed form (human), hTGFB1/var:C225R/SigPep-
organism-modification
PR:000000625
TGF-beta 1 sequence variant C225R cleaved 1 (human), hTGFB1/var:C225R/Clv:1
Yes
organism-modification
PR:000000626
TGF-beta 1 sequence variant C225R cleaved 2 (human), hTGFB1/var:C225R/Clv:2
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000625
hTGFB1/var:C225R/Clv:1
UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952 | TGF-beta 1 sequence variant 6 cleaved 1 (human)
"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952." [PRO:CNA, PRO:DAN]
enables
increased
GO:0008083
growth factor activity
relative to
PR:000000616
TGF-beta 1 active protein
PMID:11062463
;
PMID:12493741
;
PMID:12843182
located_in
GO:0005615
extracellular space
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000626
hTGFB1/var:C225R/Clv:2
UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952 | TGF-beta 1 sequence variant 6 cleaved 2 (human)
"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952." [PMID:11278244, PRO:CNA, PRO:DAN]
located_in
SO:0001561
polypeptide_partial_loss_of_function
PMID:11278244