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Documentation
Protein Ontology report - interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1
PR:000021975 -
http://purl.obolibrary.org/obo/PR_000021975
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000021975
PRO name
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1
Synonyms
PRO-Short-label
:
EXACT:
IRAK1/iso:1/Phos:1
Other
:
EXACT:
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 2 | p-IRAK1
Definition
"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation by interleukin-1 receptor-associated kinase 4 (IRAK-4) occurs on the conserved Thr residue (Thr-209 in human) located at the N terminus of the kinase domain. This is the first step following the activation of the TLR/IL-1 receptor complex. This phosphorylation results in a conformational change of the kinase domain. Example:
UniProtKB:P51617-1
, Thr-209,
MOD:00047
." [
PMID:11960013
,
PMID:14625308
, PRO:CNA, TLR:AMM]
Comment
Requested by=TLR.
PRO Category
modification
Parent
PR:000021971
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
2
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000021975
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1, IRAK1/iso:1/Phos:1
organism-modification
PR:000027178
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse), mIRAK1/iso:1/Phos:1
Yes
organism-modification
PR:000027494
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human), hIRAK1/iso:1/Phos:1
Yes
Yes
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IRAK1/iso:1/Phos:1
forms found in complexes
IRAK1/iso:1/Phos:1
Component
Complexes
PR:000027178
mIRAK1/iso:1/Phos:1
PR:000027221
pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027494
hIRAK1/iso:1/Phos:1
PR:000027495
pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000027494
hIRAK1/iso:1/Phos:1
UniProtKB:P51617-1, Thr-209, MOD:00047
"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P51617-1, Thr-209, MOD:00047." [PRO:DNx, UniProtKB:P51617]
enables
GO:0005515
protein binding
with
PR:Q9NWZ3
hIRAK4
PMID:11960013
GO:0016301
kinase activity
PMID:11960013