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Protein Ontology report - interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3
PR:000021977 - http://purl.obolibrary.org/obo/PR_000021977
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000021977   
  PRO nameinterleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 
  Synonyms
PRO-Short-label: EXACT:IRAK1/iso:1/Phos:3
Other: EXACT:interleukin-1 receptor-associated kinase 1 active | pp-IRAK1
  Definition"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation by interleukin-1 receptor-associated kinase 4 (IRAK-4) occurs on the conserved Thr residue (Thr-209 in human) located near the N terminus of the kinase domain, and on a Thr residue located in the activation loop (Thr-387 in human). The latter phosphorylation is the second step following the activation of the TLR/IL-1 receptor complex. Example: UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047." [PMID:14625308, PRO:CNA, PRO:DAN] 
  PRO Categorymodification 
  ParentPR:000021971 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification1                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000021977 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3, IRAK1/iso:1/Phos:3

organism-modification


PR:000027492 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human), hIRAK1/iso:1/Phos:3
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027492 hIRAK1/iso:1/Phos:3
UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047 | pp-IRAK1 (human)
"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 in human. UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047." [PMID:14625308, PRO:CNA]		 acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0004674 protein serine/threonine kinase activity PMID:14625308